SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h8w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		3 / 3 ALA A 558
VAL A 553
TRP A 549
 None
 0.87A 1av2C-5h8wA:
undetectable
1av2D-5h8wA:
undetectable		 1av2C-5h8wA:
4.35
1av2D-5h8wA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		4 / 6 PHE A 285
ILE A 280
ALA A 264
MET A 292
 None
 1.10A 1hk2A-5h8wA:
undetectable		 1hk2A-5h8wA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		4 / 7 ALA A 151
ILE A  68
PRO A  84
GLU A  64
 None
 1.13A 1oniA-5h8wA:
undetectable
1oniB-5h8wA:
undetectable		 1oniA-5h8wA:
15.15
1oniB-5h8wA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		4 / 6 ALA A 151
ILE A  68
PRO A  84
GLU A  64
 None
 1.16A 1oniB-5h8wA:
undetectable
1oniC-5h8wA:
undetectable		 1oniB-5h8wA:
15.15
1oniC-5h8wA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		4 / 7 ILE A  68
PRO A  84
GLU A  64
ALA A 151
 None
 1.12A 1oniG-5h8wA:
undetectable
1oniI-5h8wA:
undetectable		 1oniG-5h8wA:
15.15
1oniI-5h8wA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		5 / 12 TYR A 183
PRO A 182
GLY A 509
ILE A 219
LEU A 187
 None
 1.16A 1r30A-5h8wA:
undetectable		 1r30A-5h8wA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		5 / 12 TYR A 183
PRO A 182
GLY A 509
ILE A 219
LEU A 187
 None
 1.16A 1r30B-5h8wA:
undetectable		 1r30B-5h8wA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		3 / 3 ARG A  88
TYR A 166
LYS A 170
 None
 0.98A 1uujB-5h8wA:
undetectable		 1uujB-5h8wA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		3 / 3 ALA A 558
VAL A 553
TRP A 549
 None
 0.85A 1w5uC-5h8wA:
undetectable
1w5uD-5h8wA:
undetectable		 1w5uC-5h8wA:
4.35
1w5uD-5h8wA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		4 / 7 GLY A 396
PHE A 397
TYR A 391
THR A 378
 None
 1.16A 2aouB-5h8wA:
5.3		 2aouB-5h8wA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		5 / 12 ILE A 180
VAL A  67
LEU A  71
LEU A  40
THR A  36
 None
 0.96A 2aw1A-5h8wA:
undetectable		 2aw1A-5h8wA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		5 / 12 PHE A 397
LEU A 210
LEU A  57
LEU A  55
ILE A 208
 None
 1.06A 2bdmA-5h8wA:
undetectable		 2bdmA-5h8wA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA512_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		5 / 10 ALA A 213
TYR A 183
PHE A 397
HIS A 380
ILE A 219
 None
 1.41A 2zm8A-5h8wA:
undetectable		 2zm8A-5h8wA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		4 / 7 HIS A 380
VAL A  25
VAL A 207
ALA A  43
 None
 1.07A 3kp6B-5h8wA:
undetectable		 3kp6B-5h8wA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		4 / 6 PHE A 326
PRO A 325
GLU A 107
SER A 108
 None
 1.04A 3vlnA-5h8wA:
undetectable		 3vlnA-5h8wA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		4 / 5 ILE A 209
ALA A  39
HIS A 380
MET A 381
 None
 1.10A 4ac9B-5h8wA:
undetectable
4ac9C-5h8wA:
undetectable		 4ac9B-5h8wA:
22.31
4ac9C-5h8wA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		4 / 5 ILE A 209
ALA A  39
HIS A 380
MET A 381
 None
 1.14A 4acaB-5h8wA:
undetectable
4acaC-5h8wA:
undetectable		 4acaB-5h8wA:
22.31
4acaC-5h8wA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		4 / 5 VAL A 464
ARG A 467
MET A 436
LEU A 428
 None
 1.27A 4hojA-5h8wA:
undetectable		 4hojA-5h8wA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		4 / 8 HIS A 253
ASP A 245
SER A 255
ASP A 256
 None
None
NA  A 803 ( 4.8A)
None
 1.05A 4l7iB-5h8wA:
undetectable		 4l7iB-5h8wA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		5 / 11 GLY A  87
PHE A 154
TYR A 157
PRO A 165
TYR A 166
 None
 1.16A 4rtrA-5h8wA:
4.6		 4rtrA-5h8wA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		5 / 12 GLY A  87
PHE A 154
TYR A 157
PRO A 165
TYR A 166
 None
 1.16A 4rtsA-5h8wA:
undetectable		 4rtsA-5h8wA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		3 / 3 ARG A 281
GLN A 283
GLU A 287
 None
 0.86A 4tvtA-5h8wA:
undetectable		 4tvtA-5h8wA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		4 / 6 ARG A 562
ILE A 559
GLN A 563
ILE A 565
 None
 1.18A 4z4cA-5h8wA:
2.0		 4z4cA-5h8wA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		4 / 6 ARG A 562
ILE A 559
GLN A 563
ILE A 565
 None
 1.22A 4z4dA-5h8wA:
undetectable		 4z4dA-5h8wA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		3 / 3 ASN A 114
ALA A 110
ARG A  88
 None
 0.57A 5cvtB-5h8wA:
2.1		 5cvtB-5h8wA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		4 / 7 GLU A 271
MET A 268
ARG A 281
VAL A 278
 None
 1.46A 5uo7A-5h8wA:
undetectable
5uo7B-5h8wA:
undetectable		 5uo7A-5h8wA:
19.15
5uo7B-5h8wA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		5 / 12 GLU A 564
LEU A 484
GLY A 504
SER A 502
PHE A 455
 None
 0.97A 5vooD-5h8wA:
undetectable		 5vooD-5h8wA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		5 / 12 GLU A 564
LEU A 484
GLY A 504
SER A 502
PHE A 455
 None
 1.08A 5vooF-5h8wA:
3.0		 5vooF-5h8wA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		5 / 12 HIS A 380
ILE A 180
LEU A 385
LEU A 216
TYR A 391
 None
 1.47A 5ycpA-5h8wA:
undetectable		 5ycpA-5h8wA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		5 / 12 GLN A  66
GLY A 509
ILE A 209
LEU A  57
ALA A 213
 None
 1.04A 6c2mA-5h8wA:
undetectable		 6c2mA-5h8wA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5h8w ATP-DEPENDENT DNA
HELICASE TA0057
(Thermoplasma
acidophilum) 		5 / 12 GLY A  32
GLY A 405
GLY A  34
ALA A  39
PHE A 408
 None
 1.07A 6nj9K-5h8wA:
3.6		 6nj9K-5h8wA:
21.43