SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h9d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 ASP A 209
ASP A 210
ILE A 165
GLY A 202
ILE A 201
 None
 0.78A 1d4yA-5h9dA:
undetectable		 1d4yA-5h9dA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 5h9d HEPTAPRENYL
DIPHOSPHATE SYNTHASE
(HEPPP SYNTHASE)
SUBUNIT 1 FAMILY
PROTEIN
(Staphylococcus
aureus) 		5 / 11 LEU C  84
LEU C  76
SER C  54
THR C  50
VAL C  46
 None
 1.18A 1ictA-5h9dC:
undetectable
1ictC-5h9dC:
undetectable		 1ictA-5h9dC:
22.78
1ictC-5h9dC:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		4 / 4 HIS A 199
ALA A 170
PHE A 205
GLY A 198
 None
 1.40A 1mjoA-5h9dA:
undetectable		 1mjoA-5h9dA:
16.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 LEU A  79
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
PO4  A 501 ( 4.9A)
None
None
None
 0.79A 1rqjA-5h9dA:
31.0		 1rqjA-5h9dA:
32.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.93A 1rqjA-5h9dA:
31.0		 1rqjA-5h9dA:
32.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.82A 1rqjA-5h9dA:
31.0		 1rqjA-5h9dA:
32.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 LEU A  79
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
PO4  A 501 ( 4.9A)
None
None
None
 0.74A 1rqjB-5h9dA:
31.0		 1rqjB-5h9dA:
32.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.90A 1rqjB-5h9dA:
31.0		 1rqjB-5h9dA:
32.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.79A 1rqjB-5h9dA:
31.0		 1rqjB-5h9dA:
32.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 1.01A 1rqjB-5h9dA:
31.0		 1rqjB-5h9dA:
32.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 ASP A 209
ASP A 210
ILE A 165
GLY A 202
ILE A 201
 None
 0.80A 1sdvB-5h9dA:
undetectable		 1sdvB-5h9dA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		6 / 11 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
None
 0.98A 1yhlA-5h9dA:
28.8		 1yhlA-5h9dA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.85A 1yhlA-5h9dA:
28.8		 1yhlA-5h9dA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 0.98A 1yhlA-5h9dA:
28.8		 1yhlA-5h9dA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		6 / 11 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
None
 0.97A 1yq7A-5h9dA:
27.9		 1yq7A-5h9dA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		6 / 11 LEU A  79
ASP A  82
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
None
PO4  A 501 ( 4.9A)
None
None
 1.05A 1yq7A-5h9dA:
27.9		 1yq7A-5h9dA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 0.99A 1yq7A-5h9dA:
27.9		 1yq7A-5h9dA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
PO4  A 501 ( 4.9A)
None
None
None
 0.80A 1yv5A-5h9dA:
28.1		 1yv5A-5h9dA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.86A 1yv5A-5h9dA:
28.1		 1yv5A-5h9dA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.83A 1yv5A-5h9dA:
28.1		 1yv5A-5h9dA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 0.93A 1yv5A-5h9dA:
28.1		 1yv5A-5h9dA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 ASP A  82
ASP A  86
ARG A  91
LYS A 168
THR A 169
 None
None
PO4  A 501 ( 4.9A)
None
None
 1.11A 1zw5A-5h9dA:
28.9		 1zw5A-5h9dA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 ARG A  91
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 ( 4.9A)
None
None
None
None
 1.13A 2e91A-5h9dA:
22.7		 2e91A-5h9dA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 ARG A  91
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 ( 4.9A)
None
None
None
None
 1.21A 2e91B-5h9dA:
21.8		 2e91B-5h9dA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 ASP A  82
ARG A  91
LYS A 168
THR A 169
GLN A 206
 None
PO4  A 501 ( 4.9A)
None
None
None
 0.99A 2f89F-5h9dA:
29.3		 2f89F-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		6 / 11 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
None
 0.99A 2f8cF-5h9dA:
28.5		 2f8cF-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.89A 2f8cF-5h9dA:
28.5		 2f8cF-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 0.99A 2f8cF-5h9dA:
28.5		 2f8cF-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		6 / 10 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
None
 0.99A 2f8zF-5h9dA:
29.2		 2f8zF-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.88A 2f8zF-5h9dA:
29.2		 2f8zF-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 0.98A 2f8zF-5h9dA:
29.2		 2f8zF-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		6 / 12 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
None
 0.94A 2f94F-5h9dA:
28.4		 2f94F-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.76A 2f94F-5h9dA:
28.4		 2f94F-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 0.94A 2f94F-5h9dA:
28.4		 2f94F-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
PO4  A 501 ( 4.9A)
None
None
None
 0.89A 2f9kF-5h9dA:
28.4		 2f9kF-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.97A 2f9kF-5h9dA:
28.4		 2f9kF-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.90A 2f9kF-5h9dA:
28.4		 2f9kF-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 0.98A 2f9kF-5h9dA:
28.4		 2f9kF-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 GLY A 226
ASP A 213
THR A 235
ILE A 238
ARG A 272
 None
 1.25A 2f9wA-5h9dA:
undetectable
2f9wB-5h9dA:
0.8		 2f9wA-5h9dA:
21.10
2f9wB-5h9dA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 8 ARG A 272
GLY A 226
ASP A 213
THR A 235
ILE A 238
 None
 1.40A 2f9wA-5h9dA:
undetectable
2f9wB-5h9dA:
undetectable		 2f9wA-5h9dA:
21.10
2f9wB-5h9dA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_1
(PROTEASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 ASP A 209
ASP A 210
ILE A 165
GLY A 202
ILE A 201
 None
 0.87A 2nmyA-5h9dA:
undetectable		 2nmyA-5h9dA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		6 / 9 LEU A  79
ASP A  82
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
None
PO4  A 501 ( 4.9A)
None
None
 1.01A 2o1oA-5h9dA:
26.0		 2o1oA-5h9dA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
PO4  A 501 ( 4.9A)
None
None
None
 0.98A 2o1oB-5h9dA:
26.6		 2o1oB-5h9dA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 1.06A 2o1oB-5h9dA:
26.6		 2o1oB-5h9dA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  82
ASP A  86
ARG A  91
LYS A 168
 PO4  A 501 (-4.5A)
None
None
PO4  A 501 ( 4.9A)
None
 1.11A 2o1oB-5h9dA:
26.6		 2o1oB-5h9dA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 1.16A 2q58A-5h9dA:
26.2		 2q58A-5h9dA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 ASP A  82
ASP A  86
ARG A  91
LYS A 168
THR A 169
 None
None
PO4  A 501 ( 4.9A)
None
None
 1.20A 2q58B-5h9dA:
26.4		 2q58B-5h9dA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  82
ARG A  91
LYS A 168
GLN A 206
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 1.03A 2qisA-5h9dA:
28.3		 2qisA-5h9dA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 ASP A 209
ASP A 210
ILE A 165
GLY A 202
ILE A 201
 None
 0.78A 2r5pD-5h9dA:
undetectable		 2r5pD-5h9dA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
HEPTAPRENYL
DIPHOSPHATE SYNTHASE
(HEPPP SYNTHASE)
SUBUNIT 1 FAMILY
PROTEIN
(Staphylococcus
aureus) 		4 / 4 TYR C  82
LEU C  84
LEU C  85
HIS A 130
 None
 1.41A 2x7hB-5h9dC:
undetectable		 2x7hB-5h9dC:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 ASP A 209
ASP A 210
ILE A 165
GLY A 202
ILE A 201
 None
 0.81A 3el4A-5h9dA:
undetectable		 3el4A-5h9dA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 ASP A  82
ARG A  91
LYS A 168
THR A 169
GLN A 206
 None
PO4  A 501 ( 4.9A)
None
None
None
 1.02A 3ez3A-5h9dA:
28.2		 3ez3A-5h9dA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
PO4  A 501 ( 4.9A)
None
None
None
 0.75A 3ez3D-5h9dA:
27.5		 3ez3D-5h9dA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.90A 3ez3D-5h9dA:
27.5		 3ez3D-5h9dA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.84A 3ez3D-5h9dA:
27.5		 3ez3D-5h9dA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 0.89A 3ez3D-5h9dA:
27.5		 3ez3D-5h9dA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 ILE A 201
ARG A 192
LEU A 194
ILE A 295
LEU A 298
 None
 1.10A 3k2hB-5h9dA:
undetectable		 3k2hB-5h9dA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 LEU A  79
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
PO4  A 501 ( 4.9A)
None
None
None
 0.87A 3n45F-5h9dA:
28.4		 3n45F-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.94A 3n45F-5h9dA:
28.4		 3n45F-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.90A 3n45F-5h9dA:
28.4		 3n45F-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 0.97A 3n45F-5h9dA:
28.4		 3n45F-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
PO4  A 501 ( 4.9A)
None
None
None
 0.92A 3n46F-5h9dA:
28.3		 3n46F-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.96A 3n46F-5h9dA:
28.3		 3n46F-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.90A 3n46F-5h9dA:
28.3		 3n46F-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 0.98A 3n46F-5h9dA:
28.3		 3n46F-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 5h9d HEPTAPRENYL
DIPHOSPHATE SYNTHASE
(HEPPP SYNTHASE)
SUBUNIT 1 FAMILY
PROTEIN
(Staphylococcus
aureus) 		3 / 3 GLU C 129
PHE C 154
GLN C 181
 None
 1.01A 3r55A-5h9dC:
undetectable		 3r55A-5h9dC:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 ASP A 209
ASP A 210
ILE A 165
GLY A 202
ILE A 201
 None
 0.86A 3spkA-5h9dA:
undetectable		 3spkA-5h9dA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 LYS A  41
VAL A  43
HIS A  75
 PO4  A 501 (-2.7A)
None
PO4  A 501 (-4.5A)
 1.02A 3tj7A-5h9dA:
undetectable		 3tj7A-5h9dA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 VAL A 191
ILE A  74
ILE A 133
VAL A 129
LEU A 132
 None
 0.93A 3w68C-5h9dA:
3.4		 3w68C-5h9dA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 VAL A 191
ILE A  74
ILE A 133
VAL A 129
LEU A 132
 None
 0.98A 3w68D-5h9dA:
3.0		 3w68D-5h9dA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		4 / 5 LEU A 114
GLY A 110
ILE A  85
VAL A  84
 None
 0.86A 3wrkA-5h9dA:
0.8		 3wrkA-5h9dA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 5h9d HEPTAPRENYL
DIPHOSPHATE SYNTHASE
(HEPPP SYNTHASE)
SUBUNIT 1 FAMILY
PROTEIN
(Staphylococcus
aureus) 		4 / 7 ASN C 169
TYR C 168
LEU C 177
PHE C 154
 None
 1.16A 4awuA-5h9dC:
undetectable		 4awuA-5h9dC:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
HEPTAPRENYL
DIPHOSPHATE SYNTHASE
(HEPPP SYNTHASE)
SUBUNIT 1 FAMILY
PROTEIN
(Staphylococcus
aureus) 		5 / 10 MET A 122
ALA A  20
LEU A 116
GLY A 117
ALA C 124
 None
 1.19A 4fe1A-5h9dA:
3.8
4fe1J-5h9dA:
undetectable		 4fe1A-5h9dA:
16.51
4fe1J-5h9dA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 ASP A  86
ASP A 210
GLU A 144
ASP A 228
 None
 1.13A 4fevB-5h9dA:
undetectable		 4fevB-5h9dA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 ASP A  86
ASP A 210
GLU A 144
ASP A 228
 None
 1.15A 4fewB-5h9dA:
undetectable		 4fewB-5h9dA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		4 / 8 ASP A  86
ASP A 210
GLU A 144
ASP A 228
 None
 1.19A 4gkhD-5h9dA:
undetectable		 4gkhD-5h9dA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 LEU A  36
GLU A  14
ILE A  74
GLY A 117
LEU A 116
 None
 1.26A 4j26A-5h9dA:
undetectable		 4j26A-5h9dA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
PO4  A 501 ( 4.9A)
None
None
None
 0.77A 4kpdA-5h9dA:
29.1		 4kpdA-5h9dA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.87A 4kpdA-5h9dA:
29.1		 4kpdA-5h9dA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.80A 4kpdA-5h9dA:
29.1		 4kpdA-5h9dA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 0.95A 4kpdA-5h9dA:
29.1		 4kpdA-5h9dA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 LEU A  79
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
PO4  A 501 ( 4.9A)
None
None
None
 0.83A 4kpjA-5h9dA:
28.2		 4kpjA-5h9dA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.93A 4kpjA-5h9dA:
28.2		 4kpjA-5h9dA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.86A 4kpjA-5h9dA:
28.2		 4kpjA-5h9dA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 1.00A 4kpjA-5h9dA:
28.2		 4kpjA-5h9dA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
PO4  A 501 ( 4.9A)
None
None
None
 0.89A 4kq5A-5h9dA:
28.2		 4kq5A-5h9dA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.93A 4kq5A-5h9dA:
28.2		 4kq5A-5h9dA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.90A 4kq5A-5h9dA:
28.2		 4kq5A-5h9dA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
PO4  A 501 ( 4.9A)
None
None
None
 0.79A 4kqsA-5h9dA:
29.2		 4kqsA-5h9dA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.90A 4kqsA-5h9dA:
29.2		 4kqsA-5h9dA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.83A 4kqsA-5h9dA:
29.2		 4kqsA-5h9dA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 0.99A 4kqsA-5h9dA:
29.2		 4kqsA-5h9dA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 ASP A 209
ASP A 210
ILE A 165
GLY A 202
ILE A 201
 None
 0.77A 4njuA-5h9dA:
undetectable		 4njuA-5h9dA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 ASP A 209
ASP A 210
ILE A 165
GLY A 202
ILE A 201
 None
 0.80A 4njuC-5h9dA:
undetectable		 4njuC-5h9dA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
PO4  A 501 ( 4.9A)
None
None
None
 0.77A 4nkeA-5h9dA:
28.3		 4nkeA-5h9dA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.86A 4nkeA-5h9dA:
28.3		 4nkeA-5h9dA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.81A 4nkeA-5h9dA:
28.3		 4nkeA-5h9dA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 0.96A 4nkeA-5h9dA:
28.3		 4nkeA-5h9dA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 LEU A  79
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
PO4  A 501 ( 4.9A)
None
None
None
 0.81A 4nkfA-5h9dA:
28.4		 4nkfA-5h9dA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.96A 4nkfA-5h9dA:
28.4		 4nkfA-5h9dA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 0.99A 4nkfA-5h9dA:
28.4		 4nkfA-5h9dA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		6 / 10 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
None
 0.96A 4nuaA-5h9dA:
28.4		 4nuaA-5h9dA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.84A 4nuaA-5h9dA:
28.4		 4nuaA-5h9dA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 0.95A 4nuaA-5h9dA:
28.4		 4nuaA-5h9dA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		4 / 6 ILE A  74
ILE A  49
ILE A 175
LEU A 121
 None
 0.62A 4o8fB-5h9dA:
1.8		 4o8fB-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 LEU A  79
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
PO4  A 501 ( 4.9A)
None
None
None
 0.80A 4oguA-5h9dA:
28.2		 4oguA-5h9dA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.90A 4oguA-5h9dA:
28.2		 4oguA-5h9dA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.85A 4oguA-5h9dA:
28.2		 4oguA-5h9dA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 0.95A 4oguA-5h9dA:
28.2		 4oguA-5h9dA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 LEU A  79
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
PO4  A 501 ( 4.9A)
None
None
None
 0.89A 4p0wA-5h9dA:
29.0		 4p0wA-5h9dA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.94A 4p0wA-5h9dA:
29.0		 4p0wA-5h9dA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.92A 4p0wA-5h9dA:
29.0		 4p0wA-5h9dA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 1.02A 4p0wA-5h9dA:
29.0		 4p0wA-5h9dA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		6 / 10 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
None
 0.96A 4rxdA-5h9dA:
28.0		 4rxdA-5h9dA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.83A 4rxdA-5h9dA:
28.0		 4rxdA-5h9dA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 0.94A 4rxdA-5h9dA:
28.0		 4rxdA-5h9dA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		6 / 10 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
None
 0.94A 4rxdB-5h9dA:
28.4		 4rxdB-5h9dA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.83A 4rxdB-5h9dA:
28.4		 4rxdB-5h9dA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 0.94A 4rxdB-5h9dA:
28.4		 4rxdB-5h9dA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		6 / 10 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
None
 0.95A 4rxdC-5h9dA:
28.4		 4rxdC-5h9dA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.82A 4rxdC-5h9dA:
28.4		 4rxdC-5h9dA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 0.94A 4rxdC-5h9dA:
28.4		 4rxdC-5h9dA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		4 / 8 LEU A  79
ASP A  86
ARG A  91
LYS A 168
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
 0.85A 4umjA-5h9dA:
27.9		 4umjA-5h9dA:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1298_1
(GERANYLTRANSTRANSFER
ASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		4 / 4 ILE A 173
PHE A 205
GLN A 206
ASP A 209
 None
 1.19A 4umjA-5h9dA:
27.9		 4umjA-5h9dA:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.93A 4umjB-5h9dA:
28.0		 4umjB-5h9dA:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 9 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.71A 4umjB-5h9dA:
28.0		 4umjB-5h9dA:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		4 / 6 HIS A  75
GLY A  40
GLU A  72
ARG A  42
 PO4  A 501 (-4.5A)
PO4  A 501 (-3.5A)
None
None
 1.12A 4zbqA-5h9dA:
2.9		 4zbqA-5h9dA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		6 / 12 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
None
 0.97A 5cg5A-5h9dA:
28.0		 5cg5A-5h9dA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.83A 5cg5A-5h9dA:
28.0		 5cg5A-5h9dA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 0.96A 5cg5A-5h9dA:
28.0		 5cg5A-5h9dA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 LEU A  79
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
PO4  A 501 ( 4.9A)
None
None
None
 0.78A 5cg6A-5h9dA:
28.5		 5cg6A-5h9dA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.87A 5cg6A-5h9dA:
28.5		 5cg6A-5h9dA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.78A 5cg6A-5h9dA:
28.5		 5cg6A-5h9dA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 0.98A 5cg6A-5h9dA:
28.5		 5cg6A-5h9dA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5h9d HEPTAPRENYL
DIPHOSPHATE SYNTHASE
(HEPPP SYNTHASE)
SUBUNIT 1 FAMILY
PROTEIN
(Staphylococcus
aureus) 		4 / 6 VAL C 102
SER C  98
ILE C  51
PHE C 132
 None
 0.94A 5jw1B-5h9dC:
undetectable		 5jw1B-5h9dC:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		4 / 6 SER A  61
ARG A  16
GLU A  62
TYR A  65
 None
 1.39A 5x7pA-5h9dA:
undetectable		 5x7pA-5h9dA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		4 / 6 SER A  61
ARG A  16
GLU A  62
TYR A  65
 None
 1.38A 5x7pB-5h9dA:
undetectable		 5x7pB-5h9dA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		4 / 6 SER A  61
ARG A  16
GLU A  62
TYR A  65
 None
 1.41A 5x7qA-5h9dA:
undetectable		 5x7qA-5h9dA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		4 / 6 SER A  61
ARG A  16
GLU A  62
TYR A  65
 None
 1.42A 5x7rA-5h9dA:
undetectable		 5x7rA-5h9dA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
HEPTAPRENYL
DIPHOSPHATE SYNTHASE
(HEPPP SYNTHASE)
SUBUNIT 1 FAMILY
PROTEIN
(Staphylococcus
aureus;
Staphylococcus
aureus) 		5 / 12 ILE C  88
ALA C  86
LEU A 118
THR C  50
ILE C  51
 None
 1.31A 5z6fA-5h9dC:
undetectable		 5z6fA-5h9dC:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 ASP A 209
ASP A 210
ILE A 165
GLY A 202
ILE A 201
 None
 0.93A 6dj1B-5h9dA:
undetectable		 6dj1B-5h9dA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 ASP A 209
ASP A 210
ILE A 165
GLY A 202
ILE A 201
 None
 0.94A 6dj2B-5h9dA:
undetectable		 6dj2B-5h9dA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 ASP A  82
ARG A  91
LYS A 168
GLN A 206
 None
PO4  A 501 ( 4.9A)
None
None
 1.42A 6g31A-5h9dA:
26.6		 6g31A-5h9dA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 ASP A  82
ARG A  91
LYS A 168
GLN A 206
 None
PO4  A 501 ( 4.9A)
None
None
 1.23A 6g31G-5h9dA:
25.7		 6g31G-5h9dA:
13.56