SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h9f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASD
(Escherichia
coli) 		5 / 12 LEU J 120
LEU J   7
VAL J 118
CYH J  43
VAL J  61
 None
 1.32A 1db1A-5h9fJ:
undetectable		 1db1A-5h9fJ:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASD
(Escherichia
coli) 		5 / 12 LEU J 120
LEU J   7
VAL J 118
CYH J  43
VAL J  61
 None
 1.38A 1ie9A-5h9fJ:
undetectable		 1ie9A-5h9fJ:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASE
(Escherichia
coli) 		4 / 7 ILE K 123
PRO K  92
ALA K  90
ILE K 183
 None
 0.75A 1n49A-5h9fK:
undetectable		 1n49A-5h9fK:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASC
CRISPR SYSTEM
CASCADE SUBUNIT CASE
(Escherichia
coli) 		4 / 4 SER D  14
VAL D 223
PHE D 219
VAL K 166
 None
 1.33A 1o86A-5h9fD:
undetectable		 1o86A-5h9fD:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
CRISPR SYSTEM
CASCADE SUBUNIT CASD
(Escherichia
coli) 		5 / 11 ASN A 131
THR J 106
VAL A 130
PRO A 156
ALA A 155
 None
None
A  L   5 ( 4.8A)
None
None
 1.19A 1rv7A-5h9fA:
undetectable
1rv7B-5h9fA:
undetectable		 1rv7A-5h9fA:
12.33
1rv7B-5h9fA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASD
(Escherichia
coli) 		3 / 3 GLN J  47
ILE J  46
TYR J 142
 None
A  L   1 ( 4.9A)
A  L   1 ( 3.4A)
 0.68A 1vifA-5h9fJ:
undetectable		 1vifA-5h9fJ:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASC
(Escherichia
coli) 		3 / 3 THR D 260
GLU D 351
HIS D 253
 None
 0.88A 1xwfA-5h9fD:
undetectable		 1xwfA-5h9fD:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASC
(Escherichia
coli) 		3 / 3 THR D 260
GLU D 351
HIS D 253
 None
 0.88A 1xwfB-5h9fD:
undetectable		 1xwfB-5h9fD:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASC
(Escherichia
coli) 		3 / 3 THR D 260
GLU D 351
HIS D 253
 None
 0.90A 1xwfD-5h9fD:
undetectable		 1xwfD-5h9fD:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASB
(Escherichia
coli) 		5 / 10 LEU B 117
LEU B  87
LEU B 128
ILE B  72
ALA B 124
 None
 1.06A 2bxeB-5h9fB:
1.9		 2bxeB-5h9fB:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
(Escherichia
coli) 		3 / 3 PRO A 171
THR A 173
PRO A 283
 None
 0.85A 2d55C-5h9fA:
undetectable		 2d55C-5h9fA:
2.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
(Escherichia
coli) 		4 / 6 SER A 306
PRO A 305
SER A 311
VAL A 315
 None
 1.21A 2hdnI-5h9fA:
undetectable
2hdnJ-5h9fA:
undetectable
2hdnL-5h9fA:
undetectable		 2hdnI-5h9fA:
7.87
2hdnJ-5h9fA:
20.15
2hdnL-5h9fA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
(Escherichia
coli) 		4 / 6 SER A 311
VAL A 315
SER A 306
PRO A 305
 None
 1.21A 2hdnJ-5h9fA:
undetectable
2hdnK-5h9fA:
undetectable
2hdnL-5h9fA:
undetectable		 2hdnJ-5h9fA:
20.15
2hdnK-5h9fA:
7.87
2hdnL-5h9fA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
(Escherichia
coli) 		4 / 8 VAL A 415
PHE A 462
ALA A 482
ARG A 483
 None
 1.13A 2ij7C-5h9fA:
undetectable		 2ij7C-5h9fA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASC
(Escherichia
coli) 		4 / 5 ILE D 309
SER D 308
PRO D 307
PHE D 304
 None
 1.15A 3bjwC-5h9fD:
undetectable		 3bjwC-5h9fD:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
(Escherichia
coli) 		5 / 7 TYR A  28
ILE A  84
GLY A  55
LEU A  75
ARG A  70
 None
 1.26A 3elzA-5h9fA:
undetectable		 3elzA-5h9fA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
(Escherichia
coli) 		4 / 7 ILE A 146
PHE A 233
PHE A  91
GLY A 141
 None
 0.68A 3em0B-5h9fA:
undetectable		 3em0B-5h9fA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASD
(Escherichia
coli) 		5 / 12 LEU J 120
LEU J   7
VAL J 118
CYH J  43
VAL J  61
 None
 1.27A 3m7rA-5h9fJ:
undetectable		 3m7rA-5h9fJ:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
CRISPR SYSTEM
CASCADE SUBUNIT CASD
(Escherichia
coli) 		5 / 11 THR J 106
GLN J 105
ALA A 128
THR A 125
ALA A 124
 None
 0.87A 3mg0H-5h9fJ:
undetectable
3mg0I-5h9fJ:
undetectable		 3mg0H-5h9fJ:
19.50
3mg0I-5h9fJ:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASC
(Escherichia
coli) 		4 / 7 ALA D 291
TYR D 227
ARG D 226
ALA D 185
 None
 1.08A 3twpC-5h9fD:
undetectable		 3twpC-5h9fD:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASB
(Escherichia
coli) 		4 / 8 GLY B  95
ALA B 124
SER B  94
GLU B 125
 None
 0.86A 3u9hB-5h9fB:
undetectable		 3u9hB-5h9fB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
CRISPR SYSTEM
CASCADE SUBUNIT CASD
(Escherichia
coli) 		4 / 7 ASN A 131
GLU A 115
GLN A 151
TYR J  95
 None
 1.21A 3ugrA-5h9fA:
undetectable		 3ugrA-5h9fA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
(Escherichia
coli) 		4 / 6 ILE A 226
TRP A  87
ILE A  58
TRP A 211
 None
 1.30A 3welA-5h9fA:
undetectable		 3welA-5h9fA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASB
(Escherichia
coli) 		4 / 8 GLY B  95
ALA B 124
SER B  94
GLU B 125
 None
 0.87A 4bjcA-5h9fB:
undetectable		 4bjcA-5h9fB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASC
(Escherichia
coli) 		3 / 3 LYS D 354
THR D 252
ILE D  58
 None
 0.94A 4e0fB-5h9fD:
undetectable		 4e0fB-5h9fD:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
(Escherichia
coli) 		4 / 5 PHE A  91
PHE A 233
ILE A  54
GLY A  55
 None
 1.04A 4ejjC-5h9fA:
undetectable		 4ejjC-5h9fA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
(Escherichia
coli) 		4 / 7 GLU A 428
TYR A 424
GLY A 385
LYS A 389
 None
 1.06A 4fgzA-5h9fA:
undetectable		 4fgzA-5h9fA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
(Escherichia
coli) 		4 / 8 GLU A 428
TYR A 424
GLY A 385
LYS A 389
 None
 1.05A 4fgzA-5h9fA:
undetectable
4fgzB-5h9fA:
undetectable		 4fgzA-5h9fA:
19.13
4fgzB-5h9fA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASC
(Escherichia
coli) 		5 / 12 LEU D 239
GLU D 118
ARG D 165
ILE D 250
ILE D  58
 None
 1.18A 4j24B-5h9fD:
undetectable		 4j24B-5h9fD:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_B_SVRB301_1
(NUCLEOCAPSID PROTEIN)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
(Escherichia
coli) 		5 / 10 GLY A 227
ASN A 207
LYS A 205
VAL A 229
PRO A 278
 None
 1.47A 4j4vB-5h9fA:
undetectable		 4j4vB-5h9fA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
(Escherichia
coli) 		4 / 8 GLY A 227
ASN A 207
LYS A 205
PRO A 278
 None
 1.02A 4j4vC-5h9fA:
undetectable		 4j4vC-5h9fA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
CRISPR SYSTEM
CASCADE SUBUNIT CASD
(Escherichia
coli;
Escherichia
coli) 		3 / 3 ARG A 361
GLU J  22
ARG A 425
 None
 0.95A 4mwvA-5h9fA:
undetectable		 4mwvA-5h9fA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
(Escherichia
coli) 		4 / 6 ARG A  40
ALA A 147
ASP A  42
LEU A 117
 None
 1.06A 4ot2A-5h9fA:
2.2		 4ot2A-5h9fA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
CRISPR SYSTEM
CASCADE SUBUNIT CASD
(Escherichia
coli) 		5 / 11 THR J 106
GLN J 105
ALA A 128
THR A 125
ALA A 124
 None
 1.11A 4qvvH-5h9fJ:
undetectable		 4qvvH-5h9fJ:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
CRISPR SYSTEM
CASCADE SUBUNIT CASD
(Escherichia
coli) 		5 / 11 THR J 106
GLN J 105
ALA A 128
THR A 125
ALA A 124
 None
 1.10A 4qvvV-5h9fJ:
undetectable		 4qvvV-5h9fJ:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
CRISPR SYSTEM
CASCADE SUBUNIT CASD
(Escherichia
coli) 		5 / 11 THR J 106
GLN J 105
ALA A 128
THR A 125
ALA A 124
 None
 1.10A 4qvyH-5h9fJ:
undetectable		 4qvyH-5h9fJ:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASC
(Escherichia
coli) 		5 / 11 LEU D 175
GLU D 145
LYS D 144
LEU D 143
LEU D 139
 None
 1.12A 4wg0H-5h9fD:
undetectable
4wg0I-5h9fD:
undetectable
4wg0J-5h9fD:
undetectable		 4wg0H-5h9fD:
3.24
4wg0I-5h9fD:
3.24
4wg0J-5h9fD:
3.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASC
(Escherichia
coli) 		4 / 7 ILE D 160
LEU D 154
GLY D 176
LYS D 177
 None
None
None
C  L  35 ( 4.5A)
 0.99A 4z69A-5h9fD:
undetectable		 4z69A-5h9fD:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASC
(Escherichia
coli) 		4 / 8 VAL D 357
TRP D 356
HIS D   8
ASN D   6
 None
 0.93A 5a5zA-5h9fD:
undetectable		 5a5zA-5h9fD:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
CRISPR SYSTEM
CASCADE SUBUNIT CASD
(Escherichia
coli) 		4 / 7 ARG J 197
SER A  37
ARG J  33
GLU J 184
 None
 0.84A 5btaA-5h9fJ:
1.6
5btaC-5h9fJ:
undetectable
5btaD-5h9fJ:
undetectable		 5btaA-5h9fJ:
19.10
5btaC-5h9fJ:
19.10
5btaD-5h9fJ:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
CRISPR SYSTEM
CASCADE SUBUNIT CASD
(Escherichia
coli) 		4 / 6 SER A  37
ARG J  33
GLU J 184
ARG J 197
 None
 0.84A 5btaA-5h9fA:
undetectable
5btaB-5h9fA:
undetectable
5btaC-5h9fA:
undetectable		 5btaA-5h9fA:
22.01
5btaB-5h9fA:
19.13
5btaC-5h9fA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
CRISPR SYSTEM
CASCADE SUBUNIT CASD
(Escherichia
coli) 		4 / 6 ARG J 197
SER A  37
ARG J  33
GLU J 184
 None
 0.82A 5btcA-5h9fJ:
undetectable
5btcC-5h9fJ:
undetectable
5btcD-5h9fJ:
undetectable		 5btcA-5h9fJ:
19.10
5btcC-5h9fJ:
19.10
5btcD-5h9fJ:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
CRISPR SYSTEM
CASCADE SUBUNIT CASD
(Escherichia
coli) 		4 / 6 SER A  37
ARG J  33
GLU J 184
ARG J 197
 None
 0.81A 5btcA-5h9fA:
undetectable
5btcB-5h9fA:
undetectable
5btcC-5h9fA:
undetectable		 5btcA-5h9fA:
22.01
5btcB-5h9fA:
19.13
5btcC-5h9fA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
CRISPR SYSTEM
CASCADE SUBUNIT CASD
(Escherichia
coli) 		4 / 7 SER A  37
ARG J  33
GLU J 184
ARG J 197
 None
 0.84A 5btfA-5h9fA:
undetectable
5btfB-5h9fA:
undetectable
5btfC-5h9fA:
0.2		 5btfA-5h9fA:
22.01
5btfB-5h9fA:
19.13
5btfC-5h9fA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
CRISPR SYSTEM
CASCADE SUBUNIT CASD
(Escherichia
coli) 		5 / 12 THR J 106
GLN J 105
ALA A 128
THR A 125
ALA A 124
 None
 1.05A 5d0xH-5h9fJ:
undetectable
5d0xI-5h9fJ:
undetectable		 5d0xH-5h9fJ:
21.09
5d0xI-5h9fJ:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
CRISPR SYSTEM
CASCADE SUBUNIT CASD
(Escherichia
coli) 		5 / 11 THR J 106
GLN J 105
ALA A 128
THR A 125
ALA A 124
 None
 1.04A 5d0xV-5h9fJ:
undetectable		 5d0xV-5h9fJ:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
(Escherichia
coli) 		4 / 8 ILE A 310
VAL A 314
SER A 427
GLU A 428
 None
 1.14A 5dqyA-5h9fA:
undetectable		 5dqyA-5h9fA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASB
(Escherichia
coli) 		5 / 12 PRO B 126
LEU B  87
GLY B  95
ASN B  93
LEU B 120
 None
 1.49A 5emlA-5h9fB:
undetectable		 5emlA-5h9fB:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
(Escherichia
coli) 		5 / 12 ILE A 146
GLY A 142
PHE A 100
GLN A 102
ALA A  46
 None
 1.26A 5n0xB-5h9fA:
undetectable		 5n0xB-5h9fA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
CRISPR SYSTEM
CASCADE SUBUNIT CASD
(Escherichia
coli;
Escherichia
coli) 		4 / 8 LEU A 118
ALA A  46
GLN J 207
HIS A 362
 None
 1.01A 5nu7A-5h9fA:
undetectable		 5nu7A-5h9fA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
CRISPR SYSTEM
CASCADE SUBUNIT CASD
(Escherichia
coli;
Escherichia
coli) 		5 / 11 LEU A 396
GLY A 412
ARG J  83
THR A 418
ALA A 419
 None
 1.07A 5o96A-5h9fA:
undetectable
5o96B-5h9fA:
undetectable		 5o96A-5h9fA:
20.53
5o96B-5h9fA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
(Escherichia
coli) 		3 / 3 GLU A 240
HIS A 238
VAL A 106
 None
 0.59A 5trqB-5h9fA:
undetectable		 5trqB-5h9fA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASC
(Escherichia
coli) 		4 / 4 GLY D 157
LEU D 154
VAL D 115
GLU D 118
 None
 1.32A 5yw0A-5h9fD:
undetectable		 5yw0A-5h9fD:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
CRISPR SYSTEM
CASCADE SUBUNIT CASD
(Escherichia
coli;
Escherichia
coli) 		4 / 6 PHE J  21
ARG A 360
ASN A 150
ASP A  42
 None
 1.46A 6dhbA-5h9fJ:
undetectable		 6dhbA-5h9fJ:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
(Escherichia
coli) 		5 / 12 VAL A 185
GLY A  55
LEU A  36
LEU A  24
LEU A  27
 None
 0.92A 6f6iA-5h9fA:
undetectable
6f6iB-5h9fA:
undetectable		 6f6iA-5h9fA:
11.21
6f6iB-5h9fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASC
(Escherichia
coli) 		4 / 6 ILE D 160
LEU D 154
MET D 172
THR D 173
 None
 1.10A 6nmfN-5h9fD:
undetectable
6nmfW-5h9fD:
undetectable		 6nmfN-5h9fD:
21.55
6nmfW-5h9fD:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASC
(Escherichia
coli) 		5 / 11 ILE D 230
ASN D   3
ASP D 179
GLY D 180
ASN D 238
 None
 1.33A 6r2eF-5h9fD:
undetectable		 6r2eF-5h9fD:
19.84