SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h9m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 5h9m E3 UBIQUITIN-PROTEIN
LIGASE SIAH2
(Homo
sapiens) 		4 / 8 GLN A 257
GLU A 156
ASP A 159
ARG A 164
 None
 1.11A 1dtlA-5h9mA:
undetectable		 1dtlA-5h9mA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5h9m E3 UBIQUITIN-PROTEIN
LIGASE SIAH2
(Homo
sapiens) 		5 / 10 ALA A 302
ASP A 300
PHE A 245
ILE A 315
ILE A 210
 None
 1.32A 1j3jA-5h9mA:
undetectable		 1j3jA-5h9mA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5h9m E3 UBIQUITIN-PROTEIN
LIGASE SIAH2
(Homo
sapiens) 		5 / 12 TYR A 263
LEU A 265
ILE A 315
LEU A 297
PHE A 205
 None
 1.29A 2qo6A-5h9mA:
undetectable		 2qo6A-5h9mA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 5h9m E3 UBIQUITIN-PROTEIN
LIGASE SIAH2
(Homo
sapiens) 		5 / 12 ASP A 285
ILE A 248
ILE A 160
ASP A 159
ARG A 255
 None
 1.50A 3phaB-5h9mA:
undetectable		 3phaB-5h9mA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 5h9m E3 UBIQUITIN-PROTEIN
LIGASE SIAH2
(Homo
sapiens) 		4 / 7 PHE A 229
PHE A 225
PHE A 261
ALA A 262
 None
 1.11A 3t3sC-5h9mA:
undetectable		 3t3sC-5h9mA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5h9m E3 UBIQUITIN-PROTEIN
LIGASE SIAH2
(Homo
sapiens) 		4 / 5 GLY A 269
ASN A 268
ARG A 272
ARG A 273
 None
 1.24A 6dwdB-5h9mA:
undetectable
6dwdD-5h9mA:
undetectable		 6dwdB-5h9mA:
15.79
6dwdD-5h9mA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5h9m E3 UBIQUITIN-PROTEIN
LIGASE SIAH2
(Homo
sapiens) 		4 / 5 ARG A 272
ARG A 273
GLY A 269
ASN A 268
 None
 1.29A 6dwjB-5h9mA:
undetectable
6dwjD-5h9mA:
undetectable		 6dwjB-5h9mA:
15.79
6dwjD-5h9mA:
15.79