SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h9u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 12 GLY C 253
ASP C  22
GLY C  15
THR C  73
VAL C  70
None
0.97A 1fb7A-5h9uC:
undetectable
1fb7A-5h9uC:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
4 / 7 SER C  25
ASP C  26
GLU C  44
GLU C  57
None
1.17A 1knyA-5h9uC:
undetectable
1knyB-5h9uC:
undetectable
1knyA-5h9uC:
21.48
1knyB-5h9uC:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
6 / 11 ALA C  27
ASP C  30
ASP C  26
THR C  45
VAL C  52
ILE C  24
None
1.39A 1ohrA-5h9uC:
undetectable
1ohrA-5h9uC:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
6 / 11 ASP C  18
ASP C  22
GLY C  15
THR C  73
VAL C  70
ILE C  24
None
1.29A 1ohrA-5h9uC:
undetectable
1ohrA-5h9uC:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
6 / 11 GLY C 253
ASP C  22
GLY C  15
THR C  73
VAL C  70
ILE C  24
None
1.06A 1ohrA-5h9uC:
undetectable
1ohrA-5h9uC:
14.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
6 / 8 HIS C  16
PRO C  17
ASP C 175
SER C 198
PHE C 243
ASP C 251
None
0.64A 1p7lC-5h9uC:
56.0
1p7lC-5h9uC:
59.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 8 HIS C  16
PRO C  17
LYS C 177
SER C 198
ASP C 251
None
1.14A 1p7lC-5h9uC:
56.0
1p7lC-5h9uC:
59.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
6 / 8 HIS C  16
PRO C  17
ASP C 175
SER C 198
PHE C 243
ASP C 251
None
0.62A 1p7lD-5h9uC:
56.0
1p7lD-5h9uC:
59.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 8 HIS C  16
PRO C  17
LYS C 177
SER C 198
ASP C 251
None
1.15A 1p7lD-5h9uC:
56.0
1p7lD-5h9uC:
59.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
6 / 8 HIS C  16
PRO C  17
ASP C 175
SER C 198
PHE C 243
ASP C 251
None
0.61A 1rg9A-5h9uC:
56.1
1rg9A-5h9uC:
59.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 8 HIS C  16
PRO C  17
LYS C 177
SER C 198
ASP C 251
None
1.21A 1rg9A-5h9uC:
56.1
1rg9A-5h9uC:
59.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
6 / 8 HIS C  16
PRO C  17
ASP C 175
SER C 198
PHE C 243
ASP C 251
None
0.63A 1rg9B-5h9uC:
56.1
1rg9B-5h9uC:
59.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 8 HIS C  16
PRO C  17
LYS C 177
SER C 198
ASP C 251
None
1.23A 1rg9B-5h9uC:
56.1
1rg9B-5h9uC:
59.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
6 / 8 HIS C  16
PRO C  17
ASP C 175
SER C 198
PHE C 243
ASP C 251
None
0.63A 1rg9C-5h9uC:
56.1
1rg9C-5h9uC:
59.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 8 HIS C  16
PRO C  17
LYS C 177
SER C 198
ASP C 251
None
1.24A 1rg9C-5h9uC:
56.1
1rg9C-5h9uC:
59.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
6 / 8 HIS C  16
PRO C  17
ASP C 175
SER C 198
PHE C 243
ASP C 251
None
0.62A 1rg9D-5h9uC:
56.1
1rg9D-5h9uC:
59.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 8 HIS C  16
PRO C  17
LYS C 177
SER C 198
ASP C 251
None
1.25A 1rg9D-5h9uC:
56.1
1rg9D-5h9uC:
59.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
3 / 3 ASP C  18
ARG C 257
ASP C 251
None
0.93A 1vptA-5h9uC:
undetectable
1vptA-5h9uC:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
3 / 3 LYS C 188
TYR C 227
PRO C 189
None
1.22A 2j9cC-5h9uC:
0.5
2j9cC-5h9uC:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 11 GLY C 253
ASP C  22
GLY C  15
THR C  73
VAL C  70
None
0.94A 2nnpA-5h9uC:
undetectable
2nnpA-5h9uC:
13.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
7 / 8 HIS C  16
PRO C  17
ASP C 175
SER C 198
SER C 240
PHE C 243
ASP C 251
None
0.85A 2obvA-5h9uC:
55.3
2obvA-5h9uC:
49.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 8 HIS C  16
PRO C  17
LYS C 177
SER C 198
ASP C 251
None
1.14A 2obvA-5h9uC:
55.3
2obvA-5h9uC:
49.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
7 / 8 HIS C  16
PRO C  17
ASP C 175
SER C 198
SER C 240
PHE C 243
ASP C 251
None
0.78A 2p02A-5h9uC:
39.6
2p02A-5h9uC:
51.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 8 HIS C  16
PRO C  17
LYS C 177
SER C 198
ASP C 251
None
1.10A 2p02A-5h9uC:
39.6
2p02A-5h9uC:
51.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 12 ARG C  71
ILE C  24
VAL C  52
PHE C  86
ASP C  87
None
1.11A 2qeoA-5h9uC:
undetectable
2qeoA-5h9uC:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
3 / 3 LYS C 343
ARG C 324
VAL C 325
None
0.96A 2r2vC-5h9uC:
undetectable
2r2vD-5h9uC:
undetectable
2r2vC-5h9uC:
6.95
2r2vD-5h9uC:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 9 ILE C  58
ASP C  26
LEU C  29
GLY C 277
THR C 281
None
1.30A 2tsrD-5h9uC:
undetectable
2tsrD-5h9uC:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
4 / 6 TYR C 313
ALA C 312
LEU C 311
THR C 339
None
0.80A 3b6hB-5h9uC:
undetectable
3b6hB-5h9uC:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
4 / 8 LEU C 360
ALA C 352
TYR C 289
ILE C 363
None
0.83A 3cldB-5h9uC:
undetectable
3cldB-5h9uC:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 12 ILE C  33
LEU C  32
THR C 367
VAL C  41
PRO C 362
None
1.23A 3dcjA-5h9uC:
undetectable
3dcjB-5h9uC:
undetectable
3dcjA-5h9uC:
22.60
3dcjB-5h9uC:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
4 / 8 HIS C  16
PRO C  17
ASP C 175
ASP C 251
None
0.78A 4k0bB-5h9uC:
27.3
4k0bB-5h9uC:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
4 / 8 HIS C  16
PRO C  17
LYS C 177
ASP C 251
None
1.03A 4k0bB-5h9uC:
27.3
4k0bB-5h9uC:
24.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
6 / 8 HIS C  16
PRO C  17
ASP C 175
SER C 198
PHE C 243
ASP C 251
None
0.61A 4kttA-5h9uC:
35.8
4kttA-5h9uC:
51.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
6 / 8 HIS C  16
PRO C  17
ASP C 175
SER C 198
SER C 240
PHE C 243
None
0.62A 4kttA-5h9uC:
35.8
4kttA-5h9uC:
51.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 8 HIS C  16
PRO C  17
LYS C 177
SER C 198
ASP C 251
None
1.13A 4kttA-5h9uC:
35.8
4kttA-5h9uC:
51.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
7 / 8 HIS C  16
PRO C  17
ASP C 175
SER C 198
SER C 240
PHE C 243
ASP C 251
None
0.76A 4kttC-5h9uC:
52.3
4kttC-5h9uC:
51.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 8 HIS C  16
PRO C  17
LYS C 177
SER C 198
ASP C 251
None
1.16A 4kttC-5h9uC:
52.3
4kttC-5h9uC:
51.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KTV_A_ADNA403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 12 HIS C  16
PRO C  17
ASP C 175
SER C 198
ASP C 251
None
0.74A 4ktvA-5h9uC:
52.8
4ktvB-5h9uC:
54.8
4ktvA-5h9uC:
51.57
4ktvB-5h9uC:
51.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KTV_A_ADNA403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
6 / 12 HIS C  16
PRO C  17
ASP C 175
SER C 198
SER C 240
PHE C 243
None
0.54A 4ktvA-5h9uC:
52.8
4ktvB-5h9uC:
54.8
4ktvA-5h9uC:
51.57
4ktvB-5h9uC:
51.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KTV_C_ADNC403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 11 HIS C  16
PRO C  17
ASP C 175
PHE C 243
ASP C 251
None
0.77A 4ktvC-5h9uC:
52.2
4ktvD-5h9uC:
54.6
4ktvC-5h9uC:
51.57
4ktvD-5h9uC:
51.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KTV_C_ADNC403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 11 HIS C  16
PRO C  17
ASP C 175
SER C 240
PHE C 243
None
0.53A 4ktvC-5h9uC:
52.2
4ktvD-5h9uC:
54.6
4ktvC-5h9uC:
51.57
4ktvD-5h9uC:
51.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
4 / 8 HIS C  16
PRO C  17
ASP C 175
ASP C 251
None
0.78A 4l7iB-5h9uC:
27.1
4l7iB-5h9uC:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
4 / 8 HIS C  16
PRO C  17
LYS C 177
ASP C 251
None
1.07A 4l7iB-5h9uC:
27.1
4l7iB-5h9uC:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
3 / 3 ASP C  30
TRP C 380
SER C 368
None
1.01A 4lrhF-5h9uC:
undetectable
4lrhF-5h9uC:
18.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
7 / 8 HIS C  16
PRO C  17
ASP C 175
SER C 198
SER C 240
PHE C 243
ASP C 251
None
0.86A 4ndnA-5h9uC:
31.3
4ndnA-5h9uC:
50.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 8 HIS C  16
PRO C  17
LYS C 177
SER C 198
ASP C 251
None
1.10A 4ndnA-5h9uC:
31.3
4ndnA-5h9uC:
50.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
6 / 7 HIS C  16
PRO C  17
ASP C 175
SER C 240
PHE C 243
ASP C 251
None
0.73A 4ndnC-5h9uC:
52.5
4ndnC-5h9uC:
50.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
4 / 7 HIS C  16
PRO C  17
LYS C 177
ASP C 251
None
1.00A 4ndnC-5h9uC:
52.5
4ndnC-5h9uC:
50.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
4 / 8 ALA C  42
GLU C  57
ASP C 130
LYS C 282
None
0.75A 4ndnD-5h9uC:
55.4
4ndnD-5h9uC:
50.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
6 / 7 HIS C  16
PRO C  17
ASP C 175
SER C 240
PHE C 243
ASP C 251
None
0.85A 4odjA-5h9uC:
54.6
4odjA-5h9uC:
50.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
4 / 7 HIS C  16
PRO C  17
LYS C 177
ASP C 251
None
1.00A 4odjA-5h9uC:
54.6
4odjA-5h9uC:
50.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
3 / 3 PRO C 147
MET C 146
TYR C 264
None
0.84A 4qa0B-5h9uC:
undetectable
4qa0B-5h9uC:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
3 / 3 PRO C 147
MET C 146
TYR C 264
None
0.83A 4qa0A-5h9uC:
undetectable
4qa0A-5h9uC:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
3 / 3 PRO C 147
MET C 146
TYR C 264
None
0.97A 4qa2B-5h9uC:
undetectable
4qa2B-5h9uC:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
4 / 6 GLY C 277
GLU C  44
ASP C  22
ASP C  30
None
0.96A 4uckB-5h9uC:
undetectable
4uckB-5h9uC:
21.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
7 / 8 HIS C  16
PRO C  17
ASP C 175
SER C 198
SER C 240
PHE C 243
ASP C 251
None
0.81A 5a1iA-5h9uC:
54.7
5a1iA-5h9uC:
50.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 8 HIS C  16
PRO C  17
LYS C 177
SER C 198
ASP C 251
None
1.11A 5a1iA-5h9uC:
54.7
5a1iA-5h9uC:
50.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
6 / 7 HIS C  16
PRO C  17
ASP C 175
SER C 240
PHE C 243
ASP C 251
None
0.79A 5a1iA-5h9uC:
54.7
5a1iA-5h9uC:
50.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
4 / 7 HIS C  16
PRO C  17
LYS C 177
ASP C 251
None
0.99A 5a1iA-5h9uC:
54.7
5a1iA-5h9uC:
50.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
3 / 3 ARG C  23
LYS C  72
GLU C  76
None
0.57A 5d0yA-5h9uC:
undetectable
5d0yA-5h9uC:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
4 / 8 THR C  59
ASP C 130
VAL C 126
ARG C 125
None
0.93A 5nzyA-5h9uC:
undetectable
5nzyA-5h9uC:
19.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
4 / 8 ALA C  42
GLU C  57
ASP C 130
LYS C 282
None
0.71A 5t8sA-5h9uC:
57.9
5t8sA-5h9uC:
57.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
6 / 8 HIS C  16
PRO C  17
ASP C 175
SER C 198
PHE C 243
ASP C 251
None
0.65A 5t8sB-5h9uC:
57.4
5t8sB-5h9uC:
57.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 8 HIS C  16
PRO C  17
LYS C 177
SER C 198
ASP C 251
None
1.13A 5t8sB-5h9uC:
57.4
5t8sB-5h9uC:
57.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
3 / 3 SER C 276
HIS C 372
TYR C 289
None
1.03A 5y2tA-5h9uC:
undetectable
5y2tA-5h9uC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
4 / 6 GLY C  78
ASP C  87
GLY C  15
GLY C 247
None
0.74A 6ag0C-5h9uC:
undetectable
6ag0C-5h9uC:
11.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
4 / 7 ALA C  42
GLU C  57
ASP C 130
LYS C 282
None
0.62A 6fbnA-5h9uC:
54.2
6fbnA-5h9uC:
50.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
7 / 8 HIS C  16
PRO C  17
ASP C 175
SER C 198
SER C 240
PHE C 243
ASP C 251
None
0.77A 6fbnB-5h9uC:
51.2
6fbnB-5h9uC:
50.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 8 HIS C  16
PRO C  17
LYS C 177
SER C 198
ASP C 251
None
1.12A 6fbnB-5h9uC:
51.2
6fbnB-5h9uC:
50.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
7 / 8 HIS C  16
PRO C  17
ASP C 175
SER C 198
SER C 240
PHE C 243
ASP C 251
None
0.81A 6fboA-5h9uC:
55.2
6fboA-5h9uC:
35.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 8 HIS C  16
PRO C  17
LYS C 177
SER C 198
ASP C 251
None
1.10A 6fboA-5h9uC:
55.2
6fboA-5h9uC:
35.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
7 / 12 HIS C  16
PRO C  17
ASP C 175
SER C 198
SER C 240
PHE C 243
ASP C 251
None
0.80A 6fbpA-5h9uC:
55.5
6fbpB-5h9uC:
53.4
6fbpA-5h9uC:
35.59
6fbpB-5h9uC:
35.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 12 HIS C  16
PRO C  17
LYS C 177
SER C 198
ASP C 251
None
1.14A 6fbpA-5h9uC:
55.5
6fbpB-5h9uC:
53.4
6fbpA-5h9uC:
35.59
6fbpB-5h9uC:
35.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
7 / 8 HIS C  16
PRO C  17
ASP C 175
SER C 198
SER C 240
PHE C 243
ASP C 251
None
0.79A 6fcbA-5h9uC:
55.1
6fcbA-5h9uC:
50.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 8 HIS C  16
PRO C  17
LYS C 177
SER C 198
ASP C 251
None
1.15A 6fcbA-5h9uC:
55.1
6fcbA-5h9uC:
50.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
7 / 8 HIS C  16
PRO C  17
ASP C 175
SER C 198
SER C 240
PHE C 243
ASP C 251
None
0.82A 6fcdA-5h9uC:
54.7
6fcdA-5h9uC:
35.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
5 / 8 HIS C  16
PRO C  17
LYS C 177
SER C 198
ASP C 251
None
1.14A 6fcdA-5h9uC:
54.7
6fcdA-5h9uC:
35.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
3 / 3 ARG C 375
PHE C 373
GLY C 371
None
0.80A 6fgdA-5h9uC:
undetectable
6fgdA-5h9uC:
25.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
6 / 7 HIS C  16
PRO C  17
ASP C 175
SER C 240
PHE C 243
ASP C 251
None
0.80A 6g6rA-5h9uC:
54.8
6g6rA-5h9uC:
50.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus)
4 / 7 HIS C  16
PRO C  17
LYS C 177
ASP C 251
None
0.99A 6g6rA-5h9uC:
54.8
6g6rA-5h9uC:
50.84