SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ha4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5ha4 DIAMINOPIMELATE
EPIMERASE
(Acinetobacter
baumannii) 		5 / 12 ILE A 252
LEU A 250
GLY A 223
GLN A  74
ARG A 212
 None
 1.25A 2ogyA-5ha4A:
undetectable		 2ogyA-5ha4A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5ha4 DIAMINOPIMELATE
EPIMERASE
(Acinetobacter
baumannii) 		5 / 10 ILE A  32
LEU A  35
VAL A  42
GLY A  43
GLN A  46
 None
 1.15A 2wd9C-5ha4A:
undetectable		 2wd9C-5ha4A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ha4 DIAMINOPIMELATE
EPIMERASE
(Acinetobacter
baumannii) 		4 / 5 ARG A 234
LEU A 207
ILE A 178
PHE A 196
 None
 1.29A 3ln1D-5ha4A:
undetectable		 3ln1D-5ha4A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ha4 DIAMINOPIMELATE
EPIMERASE
(Acinetobacter
baumannii) 		5 / 12 MET A  16
VAL A  18
ILE A  32
LEU A  35
ALA A  25
 None
 1.08A 4o1zB-5ha4A:
undetectable		 4o1zB-5ha4A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5ha4 DIAMINOPIMELATE
EPIMERASE
(Acinetobacter
baumannii) 		5 / 12 VAL A 243
GLY A 223
PHE A 125
GLY A 231
ASP A 154
 None
 1.39A 4pevB-5ha4A:
undetectable		 4pevB-5ha4A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5ha4 DIAMINOPIMELATE
EPIMERASE
(Acinetobacter
baumannii) 		5 / 11 VAL A  79
GLY A 221
GLY A 223
ASN A 193
ILE A 252
 None
 1.33A 4zvmA-5ha4A:
undetectable
4zvmB-5ha4A:
undetectable		 4zvmA-5ha4A:
21.55
4zvmB-5ha4A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5ha4 DIAMINOPIMELATE
EPIMERASE
(Acinetobacter
baumannii) 		5 / 12 GLU A  73
GLY A  10
ASN A  13
LEU A 218
ALA A 246
 None
None
None
MRD  A 302 ( 4.5A)
MRD  A 302 (-3.6A)
 1.39A 5kc4E-5ha4A:
undetectable		 5kc4E-5ha4A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5ha4 DIAMINOPIMELATE
EPIMERASE
(Acinetobacter
baumannii) 		4 / 7 ILE A 178
GLN A 181
VAL A 182
ALA A 163
 None
 0.79A 6cduC-5ha4A:
undetectable
6cduD-5ha4A:
undetectable		 6cduC-5ha4A:
19.41
6cduD-5ha4A:
19.41