SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ha5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
3 / 3 TRP A 116
ALA A 105
VAL A 113
None
0.93A 1c4dA-5ha5A:
undetectable
1c4dB-5ha5A:
undetectable
1c4dA-5ha5A:
6.08
1c4dB-5ha5A:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 12 VAL A  94
ILE A  30
GLY A  33
ALA A  34
LEU A  12
None
0.81A 1eqhA-5ha5A:
undetectable
1eqhA-5ha5A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 12 VAL A  94
ILE A  30
GLY A  33
ALA A  34
LEU A  12
None
0.85A 1eqhB-5ha5A:
undetectable
1eqhB-5ha5A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 11 SER A 150
VAL A 151
TYR A 163
GLY A 194
PHE A 214
None
None
EDO  A 504 (-3.6A)
None
None
1.32A 1iolA-5ha5A:
25.8
1iolA-5ha5A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 12 GLY A  21
GLY A  23
ILE A  46
ASP A  47
ASP A  71
None
0.75A 1qaoA-5ha5A:
undetectable
1qaoA-5ha5A:
18.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
7 / 11 GLY A  21
ALA A  22
ASP A  71
VAL A  72
ALA A  99
VAL A 101
VAL A 122
None
1.35A 1uayA-5ha5A:
27.9
1uayA-5ha5A:
33.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
7 / 11 GLY A  21
ASP A  45
ASP A  71
VAL A  72
ALA A  99
VAL A 101
VAL A 122
None
0.60A 1uayA-5ha5A:
27.9
1uayA-5ha5A:
33.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
7 / 10 GLY A  21
ALA A  22
ASP A  71
VAL A  72
ALA A  99
VAL A 101
VAL A 122
None
1.33A 1uayB-5ha5A:
28.5
1uayB-5ha5A:
33.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
7 / 10 GLY A  21
ASP A  45
ASP A  71
VAL A  72
ALA A  99
VAL A 101
VAL A 122
None
0.57A 1uayB-5ha5A:
28.5
1uayB-5ha5A:
33.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 12 GLY A 126
ALA A 127
GLY A 100
VAL A 101
ILE A 170
None
0.91A 2avsB-5ha5A:
undetectable
2avsB-5ha5A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 12 GLY A  21
ASP A  45
ASP A  71
ASN A  98
ALA A  99
None
0.99A 2bm9E-5ha5A:
5.6
2bm9E-5ha5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 10 GLY A  23
ASP A  45
ILE A  46
ASP A  71
VAL A  72
None
0.97A 3ay0B-5ha5A:
6.8
3ay0B-5ha5A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
3 / 3 MET A 196
VAL A 251
GLU A 225
None
0.86A 3c6gA-5ha5A:
undetectable
3c6gA-5ha5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 12 GLY A  21
ALA A  29
ASP A  71
VAL A  72
VAL A 122
None
0.89A 3dmfA-5ha5A:
5.8
3dmfA-5ha5A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 12 GLY A  21
GLY A  23
ASP A  71
VAL A  72
VAL A 122
None
0.87A 3dmfA-5ha5A:
5.8
3dmfA-5ha5A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 12 GLY A 126
SER A 131
LEU A  18
VAL A  44
LEU A 173
None
1.24A 3g9eA-5ha5A:
undetectable
3g9eA-5ha5A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 12 VAL A 165
GLY A 168
ALA A 169
SER A 172
LEU A 173
None
0.61A 3hs6A-5ha5A:
undetectable
3hs6A-5ha5A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 12 GLY A 126
ALA A 127
GLY A 100
VAL A 101
ILE A 170
None
1.01A 3nu5B-5ha5A:
undetectable
3nu5B-5ha5A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 11 GLY A  23
ASP A  45
ASP A  47
ASP A  71
VAL A  72
None
0.79A 3v8vB-5ha5A:
4.4
3v8vB-5ha5A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
6 / 12 GLY A  21
GLY A  23
ASP A  45
ILE A  46
ASP A  71
ALA A  99
None
0.95A 4iv8A-5ha5A:
7.1
4iv8A-5ha5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
6 / 12 GLY A  21
GLY A  23
ASP A  45
ILE A  46
ASP A  71
ALA A  99
None
0.92A 4iv8B-5ha5A:
7.1
4iv8B-5ha5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 12 VAL A 151
ALA A 152
PHE A 214
SER A 156
GLY A 158
None
1.14A 4mm8A-5ha5A:
undetectable
4mm8A-5ha5A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 11 VAL A 151
ALA A 152
PHE A 214
SER A 156
GLY A 158
None
1.06A 4mmaA-5ha5A:
undetectable
4mmaA-5ha5A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 12 ASP A  84
LEU A  81
LEU A 134
LEU A  86
ILE A  85
None
1.08A 4x1fA-5ha5A:
undetectable
4x1fA-5ha5A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 12 ASP A  84
LEU A  81
LEU A 134
LEU A  86
ILE A  85
None
1.10A 4x1gA-5ha5A:
undetectable
4x1gA-5ha5A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
3 / 3 VAL A 188
HIS A 132
VAL A 135
None
0.68A 5jmnC-5ha5A:
undetectable
5jmnC-5ha5A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 12 GLY A  21
GLY A  23
ASP A  71
VAL A  72
THR A  73
None
0.77A 5kpcB-5ha5A:
5.2
5kpcB-5ha5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
4 / 8 ALA A  80
LEU A 134
ILE A  42
VAL A  44
None
0.84A 5nujA-5ha5A:
undetectable
5nujA-5ha5A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 12 GLY A  21
GLY A  23
ASP A  45
ILE A  46
VAL A  72
None
0.73A 5wy0A-5ha5A:
6.0
5wy0A-5ha5A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 12 GLY A  21
GLY A  27
ALA A  28
ASP A  47
ILE A  46
None
1.15A 6b3aA-5ha5A:
6.3
6b3aA-5ha5A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 12 GLY A  21
GLY A  27
ALA A  28
ASP A  47
ILE A  46
None
1.15A 6b3bA-5ha5A:
7.5
6b3bA-5ha5A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 12 GLY A  21
ASP A  45
ILE A  46
ASP A  47
ASP A  71
None
0.83A 6bq4A-5ha5A:
6.6
6bq4A-5ha5A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 12 GLY A  21
ASP A  45
ILE A  46
ASP A  47
ASP A  71
None
0.77A 6bq4B-5ha5A:
6.9
6bq4B-5ha5A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 11 VAL A 115
GLY A 162
SER A 166
ALA A 169
VAL A 101
None
1.40A 6hu9A-5ha5A:
undetectable
6hu9E-5ha5A:
undetectable
6hu9I-5ha5A:
undetectable
6hu9A-5ha5A:
20.32
6hu9E-5ha5A:
21.43
6hu9I-5ha5A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 12 GLY A  21
ALA A  29
ILE A  46
ASP A  47
VAL A  72
None
0.67A 6iftA-5ha5A:
5.2
6iftA-5ha5A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
5 / 12 GLY A  21
GLY A  23
ILE A  46
ASP A  47
VAL A  72
None
0.73A 6iftA-5ha5A:
5.2
6iftA-5ha5A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella
ovis)
4 / 7 GLY A  21
ASN A 123
GLU A 125
GLY A 126
None
0.91A 6n7fA-5ha5A:
4.1
6n7fA-5ha5A:
15.72