SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5had'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 5had PROTEIN ACCUMULATION
AND REPLICATION OF
CHLOROPLASTS 6,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 9 THR A 780
ILE A 682
VAL A 752
LEU A 707
ILE A 793
 EDO  A 901 ( 4.5A)
None
None
None
None
 1.38A 1nb9A-5hadA:
undetectable		 1nb9A-5hadA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 5had PROTEIN ACCUMULATION
AND REPLICATION OF
CHLOROPLASTS 6,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 TRP A 715
THR A 780
TYR A 778
 EDO  A 903 (-3.7A)
EDO  A 901 ( 4.5A)
EDO  A 901 (-4.3A)
 1.23A 2a3aB-5hadA:
undetectable		 2a3aB-5hadA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 5had PROTEIN ACCUMULATION
AND REPLICATION OF
CHLOROPLASTS 6,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 9 GLY A 747
THR A 780
VAL A 784
ILE A 682
VAL A 683
 None
EDO  A 901 ( 4.5A)
None
None
None
 1.21A 2nnhB-5hadA:
undetectable		 2nnhB-5hadA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5had PROTEIN ACCUMULATION
AND REPLICATION OF
CHLOROPLASTS 6,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 MET A 674
VAL A 741
ILE A 682
LEU A 751
 None
 0.77A 3hegA-5hadA:
undetectable		 3hegA-5hadA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 5had PROTEIN ACCUMULATION
AND REPLICATION OF
CHLOROPLASTS 6,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 GLY A 695
LEU A 756
GLU A 758
LEU A 734
LEU A 733
 None
EDO  A 901 ( 4.7A)
EDO  A 901 ( 3.8A)
None
None
 1.16A 4zmeA-5hadA:
undetectable		 4zmeA-5hadA:
19.87