SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ham'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5ham RICKCE
(Rickettsia
bellii) 		5 / 12 ILE A 557
ALA A 569
LEU A 567
LEU A 605
ILE A 578
 None
 1.14A 1bsxA-5hamA:
undetectable		 1bsxA-5hamA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5ham RICKCE
(Rickettsia
bellii) 		5 / 12 ILE A 557
ALA A 569
LEU A 567
LEU A 605
ILE A 578
 None
 1.14A 1bsxB-5hamA:
undetectable		 1bsxB-5hamA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5ham RICKCE
(Rickettsia
bellii) 		3 / 3 LEU A 435
HIS A 663
ILE A 666
 None
 0.68A 1s9pB-5hamA:
undetectable		 1s9pB-5hamA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5ham RICKCE
(Rickettsia
bellii) 		5 / 12 LEU A 580
THR A 565
ILE A 557
MET A 559
PHE A 452
 None
 1.11A 1xomB-5hamA:
undetectable		 1xomB-5hamA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5ham RICKCE
(Rickettsia
bellii) 		4 / 8 VAL A 566
VAL A 446
ASN A 635
GLY A 636
 None
 0.89A 3hjoB-5hamA:
undetectable		 3hjoB-5hamA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 5ham RICKCE
(Rickettsia
bellii) 		4 / 7 VAL A 566
VAL A 446
ASN A 635
GLY A 636
 None
 0.90A 3kmoB-5hamA:
undetectable		 3kmoB-5hamA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 5ham RICKCE
(Rickettsia
bellii) 		5 / 9 ASP A 624
GLY A 656
PHE A 631
SER A 626
GLY A 629
 None
 1.02A 4mm5A-5hamA:
undetectable		 4mm5A-5hamA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 5ham RICKCE
(Rickettsia
bellii) 		5 / 9 ASP A 624
GLY A 656
PHE A 631
SER A 626
GLY A 629
 None
 1.03A 4mmbA-5hamA:
undetectable		 4mmbA-5hamA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 5ham RICKCE
(Rickettsia
bellii) 		5 / 10 ASP A 624
GLY A 656
PHE A 631
SER A 626
GLY A 629
 None
 1.02A 4mmcA-5hamA:
undetectable		 4mmcA-5hamA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 5ham RICKCE
(Rickettsia
bellii) 		5 / 12 ASP A 624
GLY A 656
PHE A 631
SER A 626
GLY A 629
 None
 1.03A 4mmdB-5hamA:
undetectable		 4mmdB-5hamA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 5ham RICKCE
(Rickettsia
bellii) 		5 / 9 ASP A 624
GLY A 656
PHE A 631
SER A 626
GLY A 629
 None
 0.97A 4mmeA-5hamA:
undetectable		 4mmeA-5hamA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 5ham RICKCE
(Rickettsia
bellii) 		5 / 9 ASP A 624
GLY A 656
PHE A 631
SER A 626
GLY A 629
 None
 1.10A 4mmeB-5hamA:
undetectable		 4mmeB-5hamA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 5ham RICKCE
(Rickettsia
bellii) 		5 / 9 ASP A 624
GLY A 656
PHE A 631
SER A 626
GLY A 629
 None
 1.03A 4mmfA-5hamA:
undetectable		 4mmfA-5hamA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 5ham RICKCE
(Rickettsia
bellii) 		5 / 9 ASP A 624
GLY A 656
PHE A 631
SER A 626
GLY A 629
 None
 1.01A 4mmfB-5hamA:
undetectable		 4mmfB-5hamA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 5ham RICKCE
(Rickettsia
bellii) 		5 / 12 MET A 461
LEU A 457
GLY A 500
ASP A 501
THR A 455
 None
 1.26A 4mubA-5hamA:
undetectable		 4mubA-5hamA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 5ham RICKCE
(Rickettsia
bellii) 		5 / 11 ASP A 624
GLY A 656
PHE A 631
SER A 626
GLY A 629
 None
 1.04A 4xp4A-5hamA:
undetectable		 4xp4A-5hamA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 5ham RICKCE
(Rickettsia
bellii) 		5 / 10 ASP A 624
GLY A 656
PHE A 631
SER A 626
GLY A 629
 None
 1.03A 4xpbA-5hamA:
undetectable		 4xpbA-5hamA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5ham RICKCE
(Rickettsia
bellii) 		5 / 12 GLY A 606
THR A 604
ILE A 601
GLN A 577
ILE A 578
 None
 1.14A 4zvmA-5hamA:
undetectable
4zvmB-5hamA:
undetectable		 4zvmA-5hamA:
23.16
4zvmB-5hamA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 5ham RICKCE
(Rickettsia
bellii) 		4 / 4 LEU A 567
ILE A 557
PRO A 598
LEU A 600
 None
 1.20A 5eb3A-5hamA:
undetectable		 5eb3A-5hamA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5ham RICKCE
(Rickettsia
bellii) 		5 / 9 ASP A 624
GLY A 656
PHE A 631
SER A 626
GLY A 629
 None
 1.08A 6awoA-5hamA:
undetectable		 6awoA-5hamA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5ham RICKCE
(Rickettsia
bellii) 		5 / 9 ASP A 624
GLY A 656
PHE A 631
SER A 626
GLY A 629
 None
 1.09A 6awqA-5hamA:
2.0		 6awqA-5hamA:
17.97