SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hb0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 5hb0 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		5 / 11 CYH B1259
LEU B1283
LEU B1359
VAL B1292
ILE B1319
 None
 1.33A 1ee2A-5hb0B:
undetectable		 1ee2A-5hb0B:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 5hb0 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		5 / 11 CYH B1259
LEU B1283
LEU B1359
VAL B1292
ILE B1319
 None
 1.37A 1ee2B-5hb0B:
undetectable		 1ee2B-5hb0B:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 5hb0 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		4 / 5 LEU B1366
THR B1367
ARG B1391
VAL B1394
 None
 0.84A 1ekjF-5hb0B:
undetectable
1ekjG-5hb0B:
undetectable		 1ekjF-5hb0B:
17.80
1ekjG-5hb0B:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5hb0 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		5 / 11 LEU B1285
LEU B1283
ALA B1320
VAL B1287
LEU B1255
 None
 1.41A 1kt6A-5hb0B:
undetectable		 1kt6A-5hb0B:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5hb0 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		5 / 11 LEU B1285
LEU B1283
ALA B1320
VAL B1287
LEU B1255
 None
 1.43A 1kt7A-5hb0B:
undetectable		 1kt7A-5hb0B:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 5hb0 NUCLEOPORIN NUP170
NUCLEOPORIN NUP145
(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		3 / 3 ASP B1159
PHE B1176
ASN E 736
 None
 0.81A 1sg9B-5hb0B:
undetectable		 1sg9B-5hb0B:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5hb0 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		4 / 6 ASP B1301
ARG B1312
VAL B1315
ILE B1319
 None
 0.76A 2yfbB-5hb0B:
4.7		 2yfbB-5hb0B:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5hb0 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		4 / 6 VAL B1287
VAL B1315
VAL B1258
ILE B1279
 None
 0.91A 3mssD-5hb0B:
undetectable		 3mssD-5hb0B:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 5hb0 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		3 / 3 PHE B1057
SER B1097
GLN B1100
 None
 0.98A 3smtA-5hb0B:
undetectable		 3smtA-5hb0B:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 5hb0 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		4 / 8 VAL B1293
CYH B1259
ILE B1319
ILE B1279
 None
 0.76A 4afgD-5hb0B:
undetectable
4afgE-5hb0B:
undetectable		 4afgD-5hb0B:
17.14
4afgE-5hb0B:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 5hb0 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		3 / 3 GLY B1145
PRO B1146
GLN B1118
 None
 0.57A 4oltB-5hb0B:
undetectable		 4oltB-5hb0B:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 5hb0 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		3 / 3 GLY B1145
PRO B1146
GLN B1118
 None
 0.45A 4qwpB-5hb0B:
undetectable		 4qwpB-5hb0B:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5hb0 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		5 / 10 THR B1242
ILE B1170
GLN B1234
LEU B1189
PHE B1171
 None
 1.38A 4r3aB-5hb0B:
undetectable		 4r3aB-5hb0B:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 5hb0 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		5 / 12 GLY B 938
LYS B 939
GLN B1033
LEU B1035
GLU B1037
 None
 1.05A 5nwwA-5hb0B:
undetectable		 5nwwA-5hb0B:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 5hb0 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		5 / 12 LEU B1081
GLY B1145
ASP B1144
GLU B1141
PHE B1142
 None
 1.01A 5x6yC-5hb0B:
undetectable		 5x6yC-5hb0B:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5hb0 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		4 / 7 ARG B1084
LEU B1082
ALA B1115
GLN B1118
 None
 0.95A 6b89A-5hb0B:
undetectable		 6b89A-5hb0B:
9.47