SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hb1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 5hb1 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		4 / 8 ILE A 771
VAL A 782
GLY A 770
LEU A 805
 None
 0.96A 1dzmA-5hb1A:
undetectable		 1dzmA-5hb1A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 5hb1 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		4 / 5 LEU A1366
THR A1367
ARG A1391
VAL A1394
 None
 0.85A 1ekjF-5hb1A:
undetectable
1ekjG-5hb1A:
undetectable		 1ekjF-5hb1A:
14.25
1ekjG-5hb1A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 5hb1 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		4 / 8 LEU A 878
SER A 882
ARG A 884
PHE A 886
 None
 1.00A 1fapB-5hb1A:
undetectable		 1fapB-5hb1A:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 5hb1 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		4 / 7 SER A 846
GLU A 765
GLU A 769
GLU A 718
 None
 1.01A 1knyA-5hb1A:
undetectable
1knyB-5hb1A:
2.5		 1knyA-5hb1A:
14.37
1knyB-5hb1A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 5hb1 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		4 / 8 GLU A 725
SER A 846
GLU A 765
GLU A 718
 None
 0.92A 1knyA-5hb1A:
undetectable
1knyB-5hb1A:
2.6		 1knyA-5hb1A:
14.37
1knyB-5hb1A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5hb1 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		5 / 12 LEU A 763
LEU A 760
LEU A 757
ALA A 756
LEU A 669
 None
 1.04A 1s9pC-5hb1A:
undetectable		 1s9pC-5hb1A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5hb1 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		5 / 12 LEU A 763
LEU A 760
LEU A 757
GLU A 753
LEU A 669
 None
 0.83A 1s9pC-5hb1A:
undetectable		 1s9pC-5hb1A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5hb1 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		4 / 5 ARG A 642
THR A 730
LEU A 734
ALA A 726
 None
 1.48A 2e1qD-5hb1A:
undetectable		 2e1qD-5hb1A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 5hb1 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		5 / 12 LEU A 724
ALA A 616
GLN A 621
LEU A 680
PHE A 645
 None
 1.41A 2oaxC-5hb1A:
undetectable		 2oaxC-5hb1A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 5hb1 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		5 / 12 ILE A 611
SER A 671
ALA A 675
LEU A 676
ALA A 749
 None
 0.93A 2yvlA-5hb1A:
undetectable		 2yvlA-5hb1A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 5hb1 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		5 / 12 ILE A 611
SER A 671
ALA A 675
LEU A 676
ALA A 749
 None
 0.91A 2yvlC-5hb1A:
undetectable		 2yvlC-5hb1A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5hb1 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		4 / 6 VAL A1287
VAL A1315
VAL A1258
ILE A1279
 None
 0.97A 3mssD-5hb1A:
undetectable		 3mssD-5hb1A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5hb1 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		5 / 12 TYR A 905
GLU A 867
ALA A 865
SER A 907
LEU A 875
 None
 1.19A 3ou6C-5hb1A:
undetectable		 3ou6C-5hb1A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5hb1 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		5 / 12 TYR A 905
GLU A 867
ALA A 865
SER A 907
LEU A 875
 None
 1.20A 3ou6D-5hb1A:
undetectable		 3ou6D-5hb1A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 5hb1 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		4 / 8 VAL A1293
CYH A1259
ILE A1319
ILE A1279
 None
 0.71A 4afgD-5hb1A:
undetectable
4afgE-5hb1A:
undetectable		 4afgD-5hb1A:
13.48
4afgE-5hb1A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 5hb1 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		4 / 5 LEU A1244
SER A1246
LEU A1291
ASN A1252
 None
 1.23A 4n09B-5hb1A:
undetectable		 4n09B-5hb1A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 5hb1 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		4 / 5 LEU A1244
SER A1246
LEU A1291
ASN A1252
 None
 1.22A 4n09C-5hb1A:
undetectable		 4n09C-5hb1A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5hb1 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		5 / 10 THR A1242
ILE A1170
GLN A1234
LEU A1189
PHE A1171
 None
 1.48A 4r3aB-5hb1A:
undetectable		 4r3aB-5hb1A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5hb1 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		6 / 11 ALA A 614
LEU A 615
LEU A 676
ASN A 727
LEU A 724
LEU A 720
 None
 1.37A 4wg0C-5hb1A:
undetectable
4wg0D-5hb1A:
undetectable
4wg0E-5hb1A:
undetectable		 4wg0C-5hb1A:
1.33
4wg0D-5hb1A:
1.33
4wg0E-5hb1A:
1.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5hb1 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		6 / 11 ALA A 614
LEU A 615
LEU A 676
ASN A 727
LEU A 724
LEU A 720
 None
 1.40A 4wg0E-5hb1A:
undetectable
4wg0F-5hb1A:
undetectable
4wg0G-5hb1A:
undetectable		 4wg0E-5hb1A:
1.33
4wg0F-5hb1A:
1.33
4wg0G-5hb1A:
1.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 5hb1 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		5 / 9 LEU A 878
SER A 882
ARG A 884
PHE A 886
THR A 900
 None
 1.33A 5gpgB-5hb1A:
1.5		 5gpgB-5hb1A:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 5hb1 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		4 / 6 GLU A 718
ARG A 721
LEU A 720
ARG A 719
 None
 1.18A 5l6eA-5hb1A:
undetectable
5l6eB-5hb1A:
undetectable		 5l6eA-5hb1A:
13.43
5l6eB-5hb1A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5hb1 NUCLEOPORIN NUP170
(Chaetomium
thermophilum) 		4 / 7 ARG A1084
LEU A1082
ALA A1115
GLN A1118
 None
 1.00A 6b89A-5hb1A:
undetectable		 6b89A-5hb1A:
9.23