SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hb3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		3 / 3 ALA A 508
VAL A 503
TRP A 500
 None
 0.85A 1av2C-5hb3A:
undetectable
1av2D-5hb3A:
undetectable		 1av2C-5hb3A:
2.68
1av2D-5hb3A:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		5 / 12 TYR A 965
LEU A 987
LEU A 986
HIS A 892
LEU A 957
 None
 1.18A 1fmlA-5hb3A:
undetectable		 1fmlA-5hb3A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		3 / 4 VAL A 655
TRP A 660
TRP A 658
 None
 1.05A 1gmkA-5hb3A:
undetectable
1gmkB-5hb3A:
undetectable		 1gmkA-5hb3A:
2.68
1gmkB-5hb3A:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		3 / 4 VAL A 655
TRP A 660
TRP A 658
 None
 1.25A 1gmkC-5hb3A:
undetectable
1gmkD-5hb3A:
undetectable		 1gmkC-5hb3A:
2.68
1gmkD-5hb3A:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		5 / 12 ALA A 878
GLY A 882
ALA A 874
ILE A 903
PHE A 833
 None
 1.18A 1ve3A-5hb3A:
undetectable		 1ve3A-5hb3A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		3 / 3 ALA A 508
VAL A 503
TRP A 500
 None
 0.86A 1w5uC-5hb3A:
undetectable
1w5uD-5hb3A:
undetectable		 1w5uC-5hb3A:
2.68
1w5uD-5hb3A:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		3 / 3 PHE A 588
VAL A 558
TRP A 555
 None
 0.90A 2cc8A-5hb3A:
undetectable		 2cc8A-5hb3A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		3 / 3 PHE A 588
VAL A 558
TRP A 555
 None
 0.88A 2ccbA-5hb3A:
undetectable		 2ccbA-5hb3A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		5 / 10 ALA A 960
LEU A 893
LEU A 889
LEU A 946
ARG A 846
 None
 1.19A 2ceoB-5hb3A:
undetectable		 2ceoB-5hb3A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		5 / 11 GLY A 433
ASP A 704
GLY A 437
HIS A 436
PHE A 732
 None
 1.38A 2hmaA-5hb3A:
undetectable		 2hmaA-5hb3A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		4 / 5 LEU A 682
LEU A 481
MET A 469
THR A 492
 None
 1.40A 2oaxD-5hb3A:
undetectable		 2oaxD-5hb3A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		3 / 3 PHE A 588
VAL A 558
TRP A 555
 None
 0.88A 2vx9A-5hb3A:
undetectable		 2vx9A-5hb3A:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		4 / 7 LEU A 987
ALA A 960
GLY A 963
ARG A 967
 None
 0.88A 2wq5A-5hb3A:
undetectable		 2wq5A-5hb3A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		4 / 4 TYR A 797
LEU A 798
LEU A 779
HIS A 739
 None
 1.49A 2x7hB-5hb3A:
undetectable		 2x7hB-5hb3A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		5 / 10 ALA A 960
LEU A 893
LEU A 889
LEU A 946
ARG A 846
 None
 1.16A 2xn6A-5hb3A:
undetectable
2xn6B-5hb3A:
undetectable		 2xn6A-5hb3A:
18.16
2xn6B-5hb3A:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		5 / 10 LEU A 893
LEU A 889
LEU A 946
ARG A 846
ARG A 841
 None
 0.99A 2xn7A-5hb3A:
undetectable
2xn7B-5hb3A:
undetectable		 2xn7A-5hb3A:
18.16
2xn7B-5hb3A:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 5hb3 NUCLEOPORIN NIC96
NUCLEOPORIN NUP53
(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		4 / 7 PHE B  77
PHE A 697
ILE A 659
ASN A 656
 None
 1.03A 2zseA-5hb3B:
undetectable		 2zseA-5hb3B:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		4 / 6 ILE A 726
TYR A 728
ILE A 440
HIS A 739
 None
 1.19A 3eteA-5hb3A:
undetectable
3eteE-5hb3A:
undetectable		 3eteA-5hb3A:
21.18
3eteE-5hb3A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		4 / 5 ILE A 726
TYR A 728
ILE A 440
HIS A 739
 None
 1.19A 3eteB-5hb3A:
undetectable
3eteC-5hb3A:
undetectable		 3eteB-5hb3A:
21.18
3eteC-5hb3A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		4 / 8 TYR A 746
GLU A 463
TYR A 747
ILE A 406
 None
 1.02A 3jz0B-5hb3A:
2.7		 3jz0B-5hb3A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5hb3 NUCLEOPORIN NIC96
NUCLEOPORIN NUP53
(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		5 / 12 HIS A 696
SER B  78
ALA B  72
ILE B  70
ASP B  67
 None
 1.37A 3lcvB-5hb3A:
undetectable		 3lcvB-5hb3A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		4 / 6 GLN A 652
ARG A 533
ASP A 542
LEU A 539
 None
 1.35A 4ax8A-5hb3A:
undetectable		 4ax8A-5hb3A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		4 / 8 GLU A 895
GLY A 838
THR A 885
TYR A 891
 None
 0.88A 5flcB-5hb3A:
undetectable		 5flcB-5hb3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		4 / 8 GLU A 895
GLY A 838
THR A 885
TYR A 891
 None
 0.88A 5flcF-5hb3A:
undetectable		 5flcF-5hb3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		3 / 3 ARG A 618
THR A 587
ASP A 585
 None
 0.88A 5g5gA-5hb3A:
undetectable
5g5gB-5hb3A:
undetectable		 5g5gA-5hb3A:
15.97
5g5gB-5hb3A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		4 / 6 TYR A 730
ASP A 736
HIS A 739
TYR A 781
 None
 1.19A 5ov9A-5hb3A:
undetectable		 5ov9A-5hb3A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		4 / 7 TYR A 730
ASP A 736
HIS A 739
TYR A 781
 None
 1.13A 5ov9B-5hb3A:
undetectable		 5ov9B-5hb3A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		4 / 7 ILE A1008
LEU A1005
CYH A1004
ILE A 916
 None
 0.84A 6b5vA-5hb3A:
undetectable
6b5vC-5hb3A:
0.0		 6b5vA-5hb3A:
8.67
6b5vC-5hb3A:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		4 / 7 ILE A1008
LEU A1005
CYH A1004
ILE A 916
 None
 0.84A 6b5vC-5hb3A:
0.0
6b5vD-5hb3A:
undetectable		 6b5vC-5hb3A:
8.67
6b5vD-5hb3A:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		4 / 7 ILE A1008
LEU A1005
CYH A1004
ILE A 916
 None
 0.84A 6b5vB-5hb3A:
2.3
6b5vD-5hb3A:
undetectable		 6b5vB-5hb3A:
8.67
6b5vD-5hb3A:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		3 / 3 PHE A 499
ARG A 533
ALA A 556
 None
 0.92A 6ecfB-5hb3A:
undetectable		 6ecfB-5hb3A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 5hb3 NUCLEOPORIN NIC96
(Chaetomium
thermophilum) 		5 / 12 LEU A 425
ILE A 406
LEU A 779
MET A 778
LEU A 744
 None
 1.23A 6ie8A-5hb3A:
undetectable		 6ie8A-5hb3A:
14.40