SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hb4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 9 VAL B 323
GLY B 325
ALA B 327
PHE B 429
ILE B 376
None
1.19A 1cetA-5hb4B:
undetectable
1cetA-5hb4B:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 11 LEU B1305
LEU B1306
ALA B1303
LEU B1151
ILE B1258
None
None
None
None
OS  B1803 (-4.1A)
1.28A 1g50A-5hb4B:
undetectable
1g50A-5hb4B:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 11 TRP B1317
ALA B1318
LEU B1322
LEU B1423
ALA B1368
None
1.00A 1h9zA-5hb4B:
undetectable
1h9zA-5hb4B:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 11 TRP B1317
ALA B1318
LEU B1322
LEU B1423
ALA B1368
None
1.02A 1ha2A-5hb4B:
undetectable
1ha2A-5hb4B:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 11 LEU B 497
ALA B 520
MET B 515
TYR B 475
LEU B 468
None
1.25A 1iiuA-5hb4B:
undetectable
1iiuA-5hb4B:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 7 LEU B 497
MET B 515
TYR B 475
LEU B 468
None
0.98A 1kt3A-5hb4B:
undetectable
1kt3A-5hb4B:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 11 LEU B 497
ALA B 520
MET B 515
TYR B 475
LEU B 468
None
1.20A 1kt6A-5hb4B:
undetectable
1kt6A-5hb4B:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 7 GLN B1344
PHE B1377
MET B1336
ALA B1337
None
1.17A 1linA-5hb4B:
undetectable
1linA-5hb4B:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 7 PHE B 373
ALA B 330
PHE B 364
TRP B 331
None
1.29A 1lqtA-5hb4B:
undetectable
1lqtA-5hb4B:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 7 PHE B 373
ALA B 330
PHE B 364
TRP B 331
None
1.28A 1lquA-5hb4B:
undetectable
1lquA-5hb4B:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 11 PHE B 920
LEU B 840
VAL B 836
PHE B 766
VAL B 845
None
1.43A 1q23J-5hb4B:
undetectable
1q23J-5hb4B:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 12 VAL B 793
ASN B 842
ILE B 846
VAL B 912
LEU B 790
None
1.01A 1r9oA-5hb4B:
undetectable
1r9oA-5hb4B:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 12 LEU B1070
SER B1065
VAL B1114
LEU B1052
HIS B1040
None
1.43A 1rk3A-5hb4B:
undetectable
1rk3A-5hb4B:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 5 LEU B 996
ALA B 994
LEU B1066
SER B1065
None
1.07A 1tt6B-5hb4B:
undetectable
1tt6B-5hb4B:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 7 LEU B1109
ASP B1034
THR B1032
TRP B 966
None
0.97A 1v55C-5hb4B:
2.3
1v55N-5hb4B:
undetectable
1v55P-5hb4B:
2.3
1v55C-5hb4B:
9.55
1v55N-5hb4B:
14.58
1v55P-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 6 ILE B 281
ALA B 285
THR B 289
ALA B 334
None
0.85A 1w0gA-5hb4B:
undetectable
1w0gA-5hb4B:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 6 ILE B 281
ALA B 285
THR B 289
ALA B 432
None
0.97A 1w0gA-5hb4B:
undetectable
1w0gA-5hb4B:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
3 / 3 VAL B 328
VAL B 323
TRP B 319
None
0.96A 1w5uC-5hb4B:
undetectable
1w5uD-5hb4B:
undetectable
1w5uC-5hb4B:
1.16
1w5uD-5hb4B:
1.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 9 THR B1464
LEU B1465
ALA B1500
LEU B1497
LEU B1586
None
1.31A 2azqA-5hb4B:
undetectable
2azqA-5hb4B:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 ALA B1337
PHE B1338
ALA B1342
LEU B1321
None
0.47A 2bxmA-5hb4B:
3.5
2bxmA-5hb4B:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 6 ASP B 431
THR B 289
GLU B 335
GLU B 295
None
1.28A 2dttB-5hb4B:
undetectable
2dttC-5hb4B:
undetectable
2dttB-5hb4B:
6.05
2dttC-5hb4B:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CHDN1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 LEU B1109
ASP B1034
THR B1032
TRP B 966
None
0.88A 2y69C-5hb4B:
2.3
2y69N-5hb4B:
undetectable
2y69P-5hb4B:
2.2
2y69C-5hb4B:
9.55
2y69N-5hb4B:
14.58
2y69P-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 12 LEU B1070
SER B1065
VAL B1114
LEU B1052
HIS B1040
None
1.43A 2zlcA-5hb4B:
undetectable
2zlcA-5hb4B:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 ASP B1034
THR B1032
TRP B 966
LEU B1109
None
1.02A 3ablA-5hb4B:
undetectable
3ablC-5hb4B:
4.7
3ablP-5hb4B:
2.3
3ablA-5hb4B:
14.58
3ablC-5hb4B:
9.55
3ablP-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 LEU B1109
ASP B1034
THR B1032
TRP B 966
None
0.95A 3ablC-5hb4B:
4.7
3ablN-5hb4B:
undetectable
3ablP-5hb4B:
2.3
3ablC-5hb4B:
9.55
3ablN-5hb4B:
14.58
3ablP-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 ASP B1034
THR B1032
TRP B 966
LEU B1109
None
0.98A 3abmA-5hb4B:
undetectable
3abmC-5hb4B:
2.3
3abmP-5hb4B:
2.3
3abmA-5hb4B:
14.58
3abmC-5hb4B:
9.55
3abmP-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 7 ILE B 555
LEU B 725
PHE B 649
LEU B 644
None
0.95A 3adxA-5hb4B:
undetectable
3adxA-5hb4B:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 7 ILE B1100
LEU B1070
PHE B1067
LEU B1052
None
0.98A 3adxA-5hb4B:
undetectable
3adxA-5hb4B:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 LEU B1109
ASP B1034
THR B1032
TRP B 966
None
0.92A 3asnC-5hb4B:
2.9
3asnN-5hb4B:
undetectable
3asnP-5hb4B:
2.7
3asnC-5hb4B:
9.55
3asnN-5hb4B:
14.58
3asnP-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 ASP B1034
THR B1032
TRP B 966
LEU B1109
None
0.92A 3asoA-5hb4B:
undetectable
3asoC-5hb4B:
2.3
3asoP-5hb4B:
2.3
3asoA-5hb4B:
14.58
3asoC-5hb4B:
9.55
3asoP-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 LEU B1109
ASP B1034
THR B1032
TRP B 966
None
0.92A 3asoC-5hb4B:
2.3
3asoN-5hb4B:
undetectable
3asoP-5hb4B:
2.3
3asoC-5hb4B:
9.55
3asoN-5hb4B:
14.58
3asoP-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 VAL B 931
VAL B 932
GLY B 935
LYS B 936
None
0.43A 3bjwA-5hb4B:
undetectable
3bjwA-5hb4B:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 11 LEU B 497
ALA B 529
ALA B 520
MET B 515
TYR B 475
None
1.17A 3bszF-5hb4B:
undetectable
3bszF-5hb4B:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EQM_A_ASDA601_1
(CYTOCHROME P450 19A1)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 10 ILE B 555
PHE B 556
TRP B 552
VAL B 651
LEU B 620
None
1.12A 3eqmA-5hb4B:
undetectable
3eqmA-5hb4B:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 5 ILE B 470
PHE B 429
ASP B 431
GLU B 427
None
1.16A 3kp6A-5hb4B:
undetectable
3kp6B-5hb4B:
2.2
3kp6A-5hb4B:
8.89
3kp6B-5hb4B:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
3 / 3 VAL B 328
VAL B 323
TRP B 319
None
0.90A 3l8lC-5hb4B:
undetectable
3l8lD-5hb4B:
undetectable
3l8lC-5hb4B:
1.16
3l8lD-5hb4B:
1.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
6 / 12 LEU B1101
LEU B1070
SER B1065
VAL B1114
LEU B1052
HIS B1040
None
1.50A 3m7rA-5hb4B:
undetectable
3m7rA-5hb4B:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 6 LEU B 493
PHE B 485
ILE B 471
THR B 433
None
0.80A 3mdrA-5hb4B:
undetectable
3mdrA-5hb4B:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 11 PHE B 512
LEU B 497
PHE B 485
LEU B 468
ILE B 471
None
1.37A 3o94B-5hb4B:
undetectable
3o94B-5hb4B:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 11 PHE B 512
LEU B 497
PHE B 485
LEU B 468
ILE B 471
None
1.38A 3o94C-5hb4B:
undetectable
3o94C-5hb4B:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 11 PHE B 512
LEU B 497
PHE B 485
LEU B 468
ILE B 471
None
1.38A 3o94D-5hb4B:
undetectable
3o94D-5hb4B:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 5 VAL B 765
ILE B 758
MET B 667
ARG B 710
None
1.48A 3oezA-5hb4B:
undetectable
3oezA-5hb4B:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 12 ILE B1479
ALA B1493
LEU B1497
LEU B1408
LEU B1403
None
1.10A 3ozuA-5hb4B:
undetectable
3ozuA-5hb4B:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 12 LEU B1526
LEU B1475
GLY B1472
ILE B1468
ALA B1467
None
1.06A 3uwlD-5hb4B:
undetectable
3uwlD-5hb4B:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 12 LEU B1070
SER B1065
VAL B1114
LEU B1052
HIS B1040
None
1.44A 3vt3A-5hb4B:
undetectable
3vt3A-5hb4B:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 12 LEU B1070
SER B1065
VAL B1114
LEU B1052
HIS B1040
None
1.41A 3vt7A-5hb4B:
undetectable
3vt7A-5hb4B:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 ASP B1034
THR B1032
TRP B 966
LEU B1109
None
0.92A 3wg7A-5hb4B:
undetectable
3wg7C-5hb4B:
4.7
3wg7P-5hb4B:
undetectable
3wg7A-5hb4B:
14.58
3wg7C-5hb4B:
9.55
3wg7P-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 LEU B1109
ASP B1034
THR B1032
TRP B 966
None
0.93A 3wg7C-5hb4B:
4.7
3wg7N-5hb4B:
undetectable
3wg7P-5hb4B:
undetectable
3wg7C-5hb4B:
9.55
3wg7N-5hb4B:
14.58
3wg7P-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 ASP B1034
THR B1032
TRP B 966
LEU B1109
None
1.00A 3x2qA-5hb4B:
undetectable
3x2qC-5hb4B:
2.3
3x2qP-5hb4B:
2.3
3x2qA-5hb4B:
14.58
3x2qC-5hb4B:
9.55
3x2qP-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 LEU B1109
ASP B1034
THR B1032
TRP B 966
None
0.94A 3x2qC-5hb4B:
2.3
3x2qN-5hb4B:
undetectable
3x2qP-5hb4B:
2.3
3x2qC-5hb4B:
9.55
3x2qN-5hb4B:
14.58
3x2qP-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 6 ARG B 875
ASP B 390
GLU B 717
LEU B 787
None
1.23A 4ax8A-5hb4B:
undetectable
4ax8A-5hb4B:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
3 / 3 TYR B 340
HIS B 336
ARG B 360
None
0.86A 4e7bC-5hb4B:
undetectable
4e7bC-5hb4B:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 12 VAL B1645
ALA B1641
MET B1495
LEU B1535
VAL B1534
None
1.11A 4eckA-5hb4B:
undetectable
4eckA-5hb4B:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
3 / 3 ARG B 517
ASP B 521
ARG B 397
None
0.82A 4mx0A-5hb4B:
undetectable
4mx0A-5hb4B:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 10 LEU B 497
LEU B 441
ILE B 471
LEU B 468
TYR B 475
None
1.01A 4odoA-5hb4B:
undetectable
4odoA-5hb4B:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 10 LEU B 497
LEU B 441
ILE B 471
LEU B 468
TYR B 475
None
1.05A 4odoB-5hb4B:
undetectable
4odoB-5hb4B:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 12 LEU B1066
LEU B1071
LEU B1101
ILE B1100
ILE B1021
None
0.92A 4odrA-5hb4B:
undetectable
4odrB-5hb4B:
undetectable
4odrA-5hb4B:
5.31
4odrB-5hb4B:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 11 LEU B 497
LEU B 441
ILE B 471
LEU B 468
TYR B 475
None
1.05A 4odrA-5hb4B:
undetectable
4odrB-5hb4B:
undetectable
4odrA-5hb4B:
5.31
4odrB-5hb4B:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 11 LEU B1022
ARG B1099
LEU B1074
LEU B1019
LEU B1070
None
1.14A 4or0A-5hb4B:
undetectable
4or0A-5hb4B:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 11 LEU B1029
SER B1110
LEU B1052
LEU B1103
LEU B1043
None
1.19A 4or0A-5hb4B:
undetectable
4or0A-5hb4B:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 11 LEU B1022
ARG B1099
LEU B1074
LEU B1019
LEU B1070
None
1.24A 4or0B-5hb4B:
undetectable
4or0B-5hb4B:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 11 LEU B1029
SER B1110
LEU B1052
LEU B1103
LEU B1043
None
1.10A 4or0B-5hb4B:
undetectable
4or0B-5hb4B:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 12 GLY B1198
ILE B1200
ILE B1213
LEU B1124
ILE B1075
None
1.06A 4pd4C-5hb4B:
undetectable
4pd4C-5hb4B:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 LEU B1539
VAL B1596
VAL B1646
LEU B1535
None
1.11A 4q0bA-5hb4B:
undetectable
4q0bA-5hb4B:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 5 GLN B 419
LEU B 418
SER B 415
ASP B 229
None
1.28A 4qtuD-5hb4B:
undetectable
4qtuD-5hb4B:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 12 ALA B1009
SER B1011
ALA B1155
GLY B1088
GLU B1081
None
1.13A 4r29C-5hb4B:
undetectable
4r29C-5hb4B:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
3 / 3 ARG B 304
GLU B 355
TYR B 340
None
0.72A 4r29D-5hb4B:
undetectable
4r29D-5hb4B:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 7 ILE B1427
LEU B1432
LEU B1408
ILE B1411
None
0.87A 4rmjA-5hb4B:
undetectable
4rmjA-5hb4B:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 12 TYR B1431
LEU B1400
LEU B1372
ALA B1434
PHE B1377
None
1.09A 4rtbA-5hb4B:
undetectable
4rtbA-5hb4B:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 12 TYR B1424
LEU B1420
LEU B1423
ARG B1366
ALA B1368
None
1.23A 4wcxC-5hb4B:
2.2
4wcxC-5hb4B:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 10 GLY B 395
GLN B 398
ALA B 381
ASP B 382
ALA B 385
None
1.21A 4wnuD-5hb4B:
undetectable
4wnuD-5hb4B:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 12 ASP B1537
LEU B1583
LEU B1582
ILE B1523
GLY B1592
None
0.87A 4xi3B-5hb4B:
undetectable
4xi3B-5hb4B:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 6 LEU B 886
GLU B 888
HIS B 831
PRO B 896
None
0.90A 4xi3C-5hb4B:
undetectable
4xi3C-5hb4B:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 ASP B1034
THR B1032
TRP B 966
LEU B1109
None
0.92A 5b1aA-5hb4B:
undetectable
5b1aC-5hb4B:
2.3
5b1aP-5hb4B:
2.3
5b1aA-5hb4B:
14.58
5b1aC-5hb4B:
9.55
5b1aP-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 ASP B1034
THR B1032
TRP B 966
LEU B1109
None
0.89A 5b3sA-5hb4B:
undetectable
5b3sC-5hb4B:
2.3
5b3sP-5hb4B:
2.3
5b3sA-5hb4B:
14.58
5b3sC-5hb4B:
9.55
5b3sP-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 10 LEU B1364
ALA B1368
LEU B1371
LEU B1321
LEU B1347
None
1.40A 5hyrA-5hb4B:
undetectable
5hyrA-5hb4B:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
3 / 3 VAL B 768
GLN B 724
CYH B 789
None
0.69A 5icxA-5hb4B:
undetectable
5icxE-5hb4B:
undetectable
5icxA-5hb4B:
9.37
5icxE-5hb4B:
0.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 LEU B1109
ASP B1034
THR B1032
TRP B 966
None
1.02A 5iy5C-5hb4B:
4.7
5iy5N-5hb4B:
undetectable
5iy5P-5hb4B:
4.7
5iy5C-5hb4B:
9.56
5iy5N-5hb4B:
14.58
5iy5P-5hb4B:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 12 ILE B 555
PHE B 556
TRP B 552
VAL B 651
LEU B 620
None
1.10A 5jkvA-5hb4B:
undetectable
5jkvA-5hb4B:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 12 ALA B1342
LEU B1321
SER B1212
PHE B1330
LEU B1375
None
1.13A 5m24A-5hb4B:
undetectable
5m24A-5hb4B:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_A_OQRA302_0
(SULFOTRANSFERASE)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 9 PRO B 678
MET B 675
VAL B 637
ILE B 640
PHE B 712
None
1.42A 5tixA-5hb4B:
undetectable
5tixA-5hb4B:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
3 / 3 GLU B 954
TYR B1026
ARG B1099
None
0.83A 5uunA-5hb4B:
undetectable
5uunA-5hb4B:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 10 HIS B 854
ASN B 851
ILE B 877
ILE B 881
LEU B 884
None
1.33A 5vkqC-5hb4B:
undetectable
5vkqD-5hb4B:
1.6
5vkqC-5hb4B:
22.71
5vkqD-5hb4B:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 ASP B1034
THR B1032
TRP B 966
LEU B1109
None
1.02A 5wauA-5hb4B:
undetectable
5wauC-5hb4B:
2.3
5wauc-5hb4B:
2.3
5wauA-5hb4B:
14.58
5wauC-5hb4B:
9.55
5wauc-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 ASP B1034
THR B1032
TRP B 966
LEU B1109
None
1.09A 5x19A-5hb4B:
undetectable
5x19C-5hb4B:
undetectable
5x19P-5hb4B:
4.6
5x19A-5hb4B:
14.58
5x19C-5hb4B:
9.55
5x19P-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
5 / 10 ARG B1259
ILE B 805
PHE B 800
MET B 819
ALA B 820
None
1.49A 5x66D-5hb4B:
undetectable
5x66D-5hb4B:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 ASP B1034
THR B1032
TRP B 966
LEU B1109
None
0.98A 5xdqA-5hb4B:
undetectable
5xdqC-5hb4B:
4.8
5xdqP-5hb4B:
2.3
5xdqA-5hb4B:
14.58
5xdqC-5hb4B:
9.55
5xdqP-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 LEU B1109
ASP B1034
THR B1032
TRP B 966
None
0.94A 5xdqC-5hb4B:
4.8
5xdqN-5hb4B:
undetectable
5xdqP-5hb4B:
2.3
5xdqC-5hb4B:
9.55
5xdqN-5hb4B:
14.58
5xdqP-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 LEU B1109
ASP B1034
THR B1032
TRP B 966
None
0.96A 5xdxC-5hb4B:
2.3
5xdxN-5hb4B:
undetectable
5xdxP-5hb4B:
2.3
5xdxC-5hb4B:
10.04
5xdxN-5hb4B:
14.58
5xdxP-5hb4B:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 ASP B1034
THR B1032
TRP B 966
LEU B1109
None
0.94A 5z84A-5hb4B:
undetectable
5z84C-5hb4B:
2.3
5z84P-5hb4B:
2.3
5z84A-5hb4B:
14.58
5z84C-5hb4B:
9.55
5z84P-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 7 LEU B1109
ASP B1034
THR B1032
TRP B 966
None
0.96A 5z84C-5hb4B:
2.2
5z84N-5hb4B:
undetectable
5z84P-5hb4B:
2.3
5z84C-5hb4B:
9.55
5z84N-5hb4B:
14.58
5z84P-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 ASP B1034
THR B1032
TRP B 966
LEU B1109
None
0.93A 5z85A-5hb4B:
undetectable
5z85C-5hb4B:
2.3
5z85P-5hb4B:
2.3
5z85A-5hb4B:
14.58
5z85C-5hb4B:
9.55
5z85P-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 7 LEU B1109
ASP B1034
THR B1032
TRP B 966
None
0.93A 5z85C-5hb4B:
2.3
5z85N-5hb4B:
undetectable
5z85P-5hb4B:
2.3
5z85C-5hb4B:
9.55
5z85N-5hb4B:
14.58
5z85P-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 ASP B1034
THR B1032
TRP B 966
LEU B1109
None
0.95A 5z86A-5hb4B:
undetectable
5z86C-5hb4B:
undetectable
5z86P-5hb4B:
2.3
5z86A-5hb4B:
14.58
5z86C-5hb4B:
9.55
5z86P-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 LEU B1109
ASP B1034
THR B1032
TRP B 966
None
0.95A 5z86C-5hb4B:
2.2
5z86N-5hb4B:
undetectable
5z86P-5hb4B:
2.3
5z86C-5hb4B:
9.55
5z86N-5hb4B:
14.58
5z86P-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 ASP B1034
THR B1032
TRP B 966
LEU B1109
None
0.93A 5zcoA-5hb4B:
undetectable
5zcoC-5hb4B:
2.3
5zcoP-5hb4B:
3.8
5zcoA-5hb4B:
14.58
5zcoC-5hb4B:
9.55
5zcoP-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 LEU B1109
ASP B1034
THR B1032
TRP B 966
None
0.93A 5zcoC-5hb4B:
2.3
5zcoN-5hb4B:
undetectable
5zcoP-5hb4B:
3.8
5zcoC-5hb4B:
9.55
5zcoN-5hb4B:
14.58
5zcoP-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 ASP B1034
THR B1032
TRP B 966
LEU B1109
None
0.97A 5zcpA-5hb4B:
undetectable
5zcpC-5hb4B:
4.8
5zcpP-5hb4B:
2.3
5zcpA-5hb4B:
14.58
5zcpC-5hb4B:
9.55
5zcpP-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 LEU B1109
ASP B1034
THR B1032
TRP B 966
None
0.97A 5zcpC-5hb4B:
4.8
5zcpN-5hb4B:
undetectable
5zcpP-5hb4B:
2.3
5zcpC-5hb4B:
9.55
5zcpN-5hb4B:
14.58
5zcpP-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 ASP B1034
THR B1032
TRP B 966
LEU B1109
None
0.93A 5zcqA-5hb4B:
undetectable
5zcqC-5hb4B:
2.3
5zcqP-5hb4B:
2.3
5zcqA-5hb4B:
14.58
5zcqC-5hb4B:
9.55
5zcqP-5hb4B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 7 THR B 958
ILE B1038
THR B1037
PHE B1024
None
0.83A 5zsfA-5hb4B:
undetectable
5zsfB-5hb4B:
undetectable
5zsfA-5hb4B:
4.05
5zsfB-5hb4B:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 5 ILE B 873
SER B 872
ALA B 863
LEU B 940
None
0.88A 6dwnA-5hb4B:
undetectable
6dwnA-5hb4B:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 6 TYR B1425
ALA B1410
ARG B1421
ASP B1481
None
1.00A 6hu9m-5hb4B:
0.0
6hu9q-5hb4B:
0.8
6hu9m-5hb4B:
15.73
6hu9q-5hb4B:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum)
4 / 8 ARG B1259
GLU B1263
ASP B 803
GLU B 802
None
1.19A 6mn4A-5hb4B:
undetectable
6mn4A-5hb4B:
10.29