SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hbt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 5hbt ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA 1
(Homo
sapiens) 		5 / 9 PHE B  12
TYR B  15
GLY B 114
VAL B 108
ILE B  80
 None
 1.18A 2a1oB-5hbtB:
undetectable		 2a1oB-5hbtB:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 5hbt FAB35, HEAVY CHAIN
(Rattus
norvegicus) 		4 / 6 LEU D  63
MET D  82
LEU D  80
MET D  48
 None
 1.25A 2kuhA-5hbtD:
undetectable		 2kuhA-5hbtD:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 5hbt FAB35, HEAVY CHAIN
(Rattus
norvegicus) 		4 / 6 LEU D  80
MET D  48
LEU D  63
MET D  82
 None
 1.27A 2kuhA-5hbtD:
undetectable		 2kuhA-5hbtD:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 5hbt ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA 1
(Homo
sapiens) 		5 / 12 MET B 171
LEU B  37
LEU B  35
ASN B  53
VAL B  54
 None
 1.26A 3dcjA-5hbtB:
undetectable
3dcjB-5hbtB:
undetectable		 3dcjA-5hbtB:
23.63
3dcjB-5hbtB:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 5hbt FAB35, HEAVY CHAIN
(Rattus
norvegicus) 		3 / 3 ASN D  60
ASP D  89
GLN D  86
 None
 0.69A 3eeyC-5hbtD:
undetectable		 3eeyC-5hbtD:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 5hbt FAB35, HEAVY CHAIN
(Rattus
norvegicus) 		3 / 3 ASN D  60
ASP D  89
GLN D  86
 None
 0.70A 3eeyD-5hbtD:
undetectable		 3eeyD-5hbtD:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 5hbt FAB35, HEAVY CHAIN
(Rattus
norvegicus) 		3 / 3 ASN D  60
ASP D  89
GLN D  86
 None
 0.70A 3eeyE-5hbtD:
undetectable		 3eeyE-5hbtD:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5hbt FAB35, HEAVY CHAIN
(Rattus
norvegicus) 		5 / 11 TYR D 152
HIS D 206
LEU D 115
ALA D 175
THR D  90
 None
 1.28A 3jwqB-5hbtD:
undetectable
3jwqC-5hbtD:
undetectable		 3jwqB-5hbtD:
21.83
3jwqC-5hbtD:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5hbt FAB35, HEAVY CHAIN
(Rattus
norvegicus) 		3 / 3 GLN D   3
GLU D   1
LYS D   1
 None
 1.21A 3su9A-5hbtD:
undetectable		 3su9A-5hbtD:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5hbt ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA 1
(Homo
sapiens) 		4 / 4 LEU B  37
LEU B  92
GLN B 164
GLU B 161
 None
 1.20A 4i41A-5hbtB:
1.5		 4i41A-5hbtB:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M93_B_ACTB305_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN)		 5hbt FAB35, HEAVY CHAIN
(Rattus
norvegicus) 		4 / 4 SER D  19
THR D  21
PHE D  79
LYS D  81
 None
 0.84A 4m93B-5hbtD:
21.5		 4m93B-5hbtD:
71.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5hbt FAB35, HEAVY CHAIN
(Rattus
norvegicus) 		5 / 12 GLY D  91
THR D  92
PHE D 153
LEU D  85
VAL D  12
 None
 1.26A 5hw4A-5hbtD:
undetectable		 5hw4A-5hbtD:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 5hbt FAB35, HEAVY CHAIN
(Rattus
norvegicus) 		5 / 9 VAL D 116
GLY D   8
ILE D  69
LEU D  67
LYS D  81
 None
 1.29A 6c2mC-5hbtD:
undetectable		 6c2mC-5hbtD:
18.06