SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hc4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 ILE A 182
ALA A 135
THR A 194
ARG A 200
LEU A 201
 None
 1.04A 1ddrA-5hc4A:
undetectable		 1ddrA-5hc4A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 ILE A 182
ALA A 135
THR A 194
ARG A 200
LEU A 201
 None
 1.04A 1ddsA-5hc4A:
undetectable		 1ddsA-5hc4A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 GLY A 107
GLY A 108
GLY A 109
SER A 188
HIS A 317
 TRS  A 402 ( 3.8A)
TRS  A 402 (-3.3A)
TRS  A 402 (-3.4A)
TRS  A 402 (-2.3A)
TRS  A 402 (-4.3A)
 0.37A 1dx6A-5hc4A:
20.9		 1dx6A-5hc4A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 GLU A 292
ILE A 220
GLY A 189
TYR A 104
ALA A 185
 None
None
TRS  A 402 (-4.1A)
None
None
 1.23A 1hvyB-5hc4A:
undetectable		 1hvyB-5hc4A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 TYR A 103
ILE A 177
ILE A 126
ALA A 334
ASN A 130
 None
 1.25A 1jtxA-5hc4A:
undetectable		 1jtxA-5hc4A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 ILE A 321
GLY A 191
ALA A 196
GLY A 108
TYR A 120
 None
None
None
TRS  A 402 (-3.3A)
None
 1.14A 1kiaB-5hc4A:
2.8		 1kiaB-5hc4A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 11 GLY A 108
GLY A 109
SER A 188
LEU A  24
HIS A 317
 TRS  A 402 (-3.3A)
TRS  A 402 (-3.4A)
TRS  A 402 (-2.3A)
None
TRS  A 402 (-4.3A)
 0.58A 1mx1A-5hc4A:
20.5		 1mx1A-5hc4A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 GLY A 108
GLY A 109
SER A 188
LEU A  24
HIS A 317
 TRS  A 402 (-3.3A)
TRS  A 402 (-3.4A)
TRS  A 402 (-2.3A)
None
TRS  A 402 (-4.3A)
 0.60A 1mx1F-5hc4A:
20.5		 1mx1F-5hc4A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 GLY A 107
GLY A 108
GLY A 109
SER A 188
HIS A 317
 TRS  A 402 ( 3.8A)
TRS  A 402 (-3.3A)
TRS  A 402 (-3.4A)
TRS  A 402 (-2.3A)
TRS  A 402 (-4.3A)
 0.38A 1qtiA-5hc4A:
20.0		 1qtiA-5hc4A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 GLY A 107
GLY A 108
GLY A 109
SER A 188
HIS A 317
 TRS  A 402 ( 3.8A)
TRS  A 402 (-3.3A)
TRS  A 402 (-3.4A)
TRS  A 402 (-2.3A)
TRS  A 402 (-4.3A)
 0.35A 1w6rA-5hc4A:
20.9		 1w6rA-5hc4A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		4 / 5 PHE A 322
LEU A 113
PHE A  19
MET A  22
 None
GOL  A 401 (-4.3A)
None
None
 1.29A 1wrlC-5hc4A:
undetectable		 1wrlC-5hc4A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 GLY A 108
GLY A 109
SER A 188
LEU A  24
HIS A 317
 TRS  A 402 (-3.3A)
TRS  A 402 (-3.4A)
TRS  A 402 (-2.3A)
None
TRS  A 402 (-4.3A)
 0.59A 1ya4A-5hc4A:
19.0		 1ya4A-5hc4A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 GLY A 108
GLY A 109
SER A 188
LEU A 239
HIS A 317
 TRS  A 402 (-3.3A)
TRS  A 402 (-3.4A)
TRS  A 402 (-2.3A)
None
TRS  A 402 (-4.3A)
 0.52A 1ya4B-5hc4A:
3.6		 1ya4B-5hc4A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 GLY A 108
GLY A 109
SER A 188
LEU A 239
HIS A 317
 TRS  A 402 (-3.3A)
TRS  A 402 (-3.4A)
TRS  A 402 (-2.3A)
None
TRS  A 402 (-4.3A)
 0.50A 1ya4C-5hc4A:
20.3		 1ya4C-5hc4A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		4 / 8 LEU A  56
TYR A 120
LEU A  24
LEU A 239
 None
 0.83A 2bfpA-5hc4A:
4.2		 2bfpA-5hc4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		4 / 8 LEU A  56
TYR A 120
LEU A  24
LEU A 239
 None
 0.82A 2bfpD-5hc4A:
4.4		 2bfpD-5hc4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		4 / 7 GLN A  89
ILE A 126
TYR A 120
TYR A 104
 None
 1.40A 2xz5D-5hc4A:
undetectable
2xz5E-5hc4A:
undetectable		 2xz5D-5hc4A:
21.07
2xz5E-5hc4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 GLN A 111
SER A 112
TYR A 120
LEU A  56
LEU A 239
 None
GOL  A 401 (-3.6A)
None
None
None
 1.33A 3adxA-5hc4A:
undetectable		 3adxA-5hc4A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 SER A 112
HIS A 106
TYR A 120
LEU A  56
LEU A 239
 GOL  A 401 (-3.6A)
None
None
None
None
 1.23A 3adxA-5hc4A:
undetectable		 3adxA-5hc4A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 SER A 112
HIS A 106
TYR A 120
LEU A  56
LEU A 239
 GOL  A 401 (-3.6A)
None
None
None
None
 1.37A 3dzyD-5hc4A:
undetectable		 3dzyD-5hc4A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		4 / 6 ILE A  64
THR A 319
PHE A  19
PHE A  55
 None
 1.23A 3elzB-5hc4A:
undetectable		 3elzB-5hc4A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 7 GLY A 107
GLY A 108
SER A 188
LEU A  24
HIS A 317
 TRS  A 402 ( 3.8A)
TRS  A 402 (-3.3A)
TRS  A 402 (-2.3A)
None
TRS  A 402 (-4.3A)
 1.32A 3o9mA-5hc4A:
4.6		 3o9mA-5hc4A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		4 / 7 GLY A 108
GLY A 109
SER A 188
HIS A 317
 TRS  A 402 (-3.3A)
TRS  A 402 (-3.4A)
TRS  A 402 (-2.3A)
TRS  A 402 (-4.3A)
 0.45A 3o9mA-5hc4A:
4.6		 3o9mA-5hc4A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 6 GLY A 107
GLY A 108
SER A 188
LEU A  24
HIS A 317
 TRS  A 402 ( 3.8A)
TRS  A 402 (-3.3A)
TRS  A 402 (-2.3A)
None
TRS  A 402 (-4.3A)
 1.33A 3o9mB-5hc4A:
20.9		 3o9mB-5hc4A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		4 / 6 GLY A 108
GLY A 109
SER A 188
HIS A 317
 TRS  A 402 (-3.3A)
TRS  A 402 (-3.4A)
TRS  A 402 (-2.3A)
TRS  A 402 (-4.3A)
 0.50A 3o9mB-5hc4A:
20.9		 3o9mB-5hc4A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 HIS A 317
ASP A 287
ARG A 310
GLY A 107
SER A 188
 TRS  A 402 (-4.3A)
None
None
TRS  A 402 ( 3.8A)
TRS  A 402 (-2.3A)
 0.91A 3sueB-5hc4A:
undetectable		 3sueB-5hc4A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 HIS A 317
ASP A 287
ARG A 310
GLY A 189
SER A 188
 TRS  A 402 (-4.3A)
None
None
TRS  A 402 (-4.1A)
TRS  A 402 (-2.3A)
 1.21A 3sueB-5hc4A:
undetectable		 3sueB-5hc4A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		6 / 12 HIS A 317
ASP A 287
ARG A 310
GLY A 107
SER A 188
SER A 330
 TRS  A 402 (-4.3A)
None
None
TRS  A 402 ( 3.8A)
TRS  A 402 (-2.3A)
None
 1.23A 3sueD-5hc4A:
undetectable		 3sueD-5hc4A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 HIS A 317
ASP A 287
ARG A 310
GLY A 189
SER A 188
 TRS  A 402 (-4.3A)
None
None
TRS  A 402 (-4.1A)
TRS  A 402 (-2.3A)
 1.19A 3sueD-5hc4A:
undetectable		 3sueD-5hc4A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 HIS A 317
ASP A 287
ARG A 310
GLY A 107
SER A 188
 TRS  A 402 (-4.3A)
None
None
TRS  A 402 ( 3.8A)
TRS  A 402 (-2.3A)
 0.92A 3sufA-5hc4A:
undetectable		 3sufA-5hc4A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 9 ALA A 135
GLY A 124
ILE A 127
PRO A  93
LEU A  99
 None
 1.27A 3u7sB-5hc4A:
undetectable		 3u7sB-5hc4A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		4 / 5 SER A 330
ASP A  12
ASP A   8
ILE A   5
 None
 1.25A 3uj7B-5hc4A:
undetectable		 3uj7B-5hc4A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		4 / 8 ILE A  11
ILE A  15
PHE A  19
SER A 188
 None
None
None
TRS  A 402 (-2.3A)
 0.82A 4acbC-5hc4A:
3.7		 4acbC-5hc4A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 ILE A 281
THR A 279
LEU A 199
GLY A 198
ILE A 220
 None
 1.04A 4c9lA-5hc4A:
undetectable		 4c9lA-5hc4A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 ILE A 281
THR A 279
LEU A 199
GLY A 198
ILE A 220
 None
 1.02A 4c9lB-5hc4A:
undetectable		 4c9lB-5hc4A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		6 / 12 GLY A 107
GLY A 108
GLY A 109
SER A 112
SER A 188
HIS A 317
 TRS  A 402 ( 3.8A)
TRS  A 402 (-3.3A)
TRS  A 402 (-3.4A)
GOL  A 401 (-3.6A)
TRS  A 402 (-2.3A)
TRS  A 402 (-4.3A)
 0.39A 4ey6A-5hc4A:
21.3		 4ey6A-5hc4A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 GLY A 107
GLY A 108
GLY A 109
SER A 188
HIS A 317
 TRS  A 402 ( 3.8A)
TRS  A 402 (-3.3A)
TRS  A 402 (-3.4A)
TRS  A 402 (-2.3A)
TRS  A 402 (-4.3A)
 0.34A 4ey6B-5hc4A:
18.5		 4ey6B-5hc4A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		4 / 8 GLY A 198
LYS A 202
PRO A 265
PHE A 296
 None
 1.00A 4j4vC-5hc4A:
undetectable		 4j4vC-5hc4A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 11 ILE A 220
GLY A 191
GLU A 187
GLY A 157
TYR A 251
 None
None
TRS  A 402 (-4.5A)
None
None
 1.32A 4jdsC-5hc4A:
undetectable		 4jdsC-5hc4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_A_ADNA403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 HIS A 317
ASP A 287
ASP A   8
ILE A   5
ILE A  15
 TRS  A 402 (-4.3A)
None
None
None
None
 1.27A 4ktvA-5hc4A:
undetectable
4ktvB-5hc4A:
undetectable		 4ktvA-5hc4A:
22.09
4ktvB-5hc4A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_C_ADNC403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 11 HIS A 317
ASP A 287
ASP A   8
ILE A   5
ILE A  15
 TRS  A 402 (-4.3A)
None
None
None
None
 1.23A 4ktvC-5hc4A:
undetectable
4ktvD-5hc4A:
undetectable		 4ktvC-5hc4A:
22.09
4ktvD-5hc4A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		4 / 6 ALA A  45
THR A  46
VAL A  48
VAL A 144
 None
None
None
GOL  A 401 (-4.9A)
 1.05A 5eckA-5hc4A:
undetectable		 5eckA-5hc4A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		4 / 6 ALA A  45
THR A  46
VAL A  48
VAL A 144
 None
None
None
GOL  A 401 (-4.9A)
 1.05A 5eckD-5hc4A:
undetectable		 5eckD-5hc4A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 HIS A 106
GLY A 190
ASN A 192
ALA A 263
SER A  79
 None
 1.13A 5igyA-5hc4A:
undetectable		 5igyA-5hc4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 HIS A 106
GLY A 190
ASN A 192
ALA A 263
SER A  79
 None
 1.19A 5ih0A-5hc4A:
undetectable		 5ih0A-5hc4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 HIS A 106
GLY A 190
ASN A 192
ALA A 263
SER A 163
 None
 1.05A 5ih0A-5hc4A:
undetectable		 5ih0A-5hc4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		4 / 5 TYR A 117
SER A 146
ALA A 147
GLN A  89
 GOL  A 401 (-4.8A)
None
None
None
 1.42A 5n0tA-5hc4A:
undetectable		 5n0tA-5hc4A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 PHE A 280
ILE A 337
ALA A 185
THR A 194
GLY A 293
 None
 1.10A 5veuA-5hc4A:
undetectable		 5veuA-5hc4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 PHE A 280
ILE A 337
ALA A 185
THR A 194
GLY A 293
 None
 1.03A 5veuH-5hc4A:
undetectable		 5veuH-5hc4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 SER A 330
GLY A 190
ILE A 126
ALA A 122
GLY A 107
 None
None
None
None
TRS  A 402 ( 3.8A)
 1.05A 5veuH-5hc4A:
undetectable		 5veuH-5hc4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		6 / 12 HIS A 317
ASP A 287
ARG A 310
GLY A 107
SER A 188
SER A 330
 TRS  A 402 (-4.3A)
None
None
TRS  A 402 ( 3.8A)
TRS  A 402 (-2.3A)
None
 1.26A 6c2mC-5hc4A:
undetectable		 6c2mC-5hc4A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 HIS A 317
ASP A 287
ARG A 310
GLY A 108
SER A 188
 TRS  A 402 (-4.3A)
None
None
TRS  A 402 (-3.3A)
TRS  A 402 (-2.3A)
 1.05A 6c2mC-5hc4A:
undetectable		 6c2mC-5hc4A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5hc4 LIPOLYTIC ENZYME
(uncultured
bacterium) 		5 / 12 ASP A   8
ILE A   5
ILE A  15
HIS A 317
ASP A 287
 None
None
None
TRS  A 402 (-4.3A)
None
 1.30A 6fbpA-5hc4A:
undetectable
6fbpB-5hc4A:
undetectable		 6fbpA-5hc4A:
13.33
6fbpB-5hc4A:
13.33