SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hc8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 5hc8 PRENYLTRANSFERENCE
FOR PROTEIN
(Lavandula
lanata) 		5 / 12 GLY A 198
GLY A 199
ASN A 257
ALA A 206
LEU A 233
 None
 0.97A 1bx4A-5hc8A:
undetectable		 1bx4A-5hc8A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 5hc8 PRENYLTRANSFERENCE
FOR PROTEIN
(Lavandula
lanata) 		4 / 5 ARG A  79
LYS A  83
ALA A  82
GLY A  77
 PIS  A 402 (-4.4A)
None
None
PIS  A 402 (-3.2A)
 1.15A 1e7cA-5hc8A:
undetectable		 1e7cA-5hc8A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 5hc8 PRENYLTRANSFERENCE
FOR PROTEIN
(Lavandula
lanata) 		5 / 11 ALA A 119
LEU A 120
LEU A 135
HIS A  93
SER A 128
 61G  A 403 (-4.8A)
None
61G  A 403 ( 4.5A)
PIS  A 402 (-4.1A)
None
 1.01A 1h9zA-5hc8A:
undetectable		 1h9zA-5hc8A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 5hc8 PRENYLTRANSFERENCE
FOR PROTEIN
(Lavandula
lanata) 		5 / 11 ALA A 119
LEU A 120
LEU A 135
HIS A  93
SER A 128
 61G  A 403 (-4.8A)
None
61G  A 403 ( 4.5A)
PIS  A 402 (-4.1A)
None
 1.07A 1ha2A-5hc8A:
undetectable		 1ha2A-5hc8A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 5hc8 PRENYLTRANSFERENCE
FOR PROTEIN
(Lavandula
lanata) 		4 / 6 HIS A  70
LEU A 246
LEU A 263
PRO A 264
 None
 1.25A 1hz4A-5hc8A:
undetectable		 1hz4A-5hc8A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 5hc8 PRENYLTRANSFERENCE
FOR PROTEIN
(Lavandula
lanata) 		4 / 5 ILE A  74
PHE A 275
PHE A 278
ILE A 117
 ISY  A 405 (-4.7A)
None
None
None
 1.12A 2hjhA-5hc8A:
2.2		 2hjhA-5hc8A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 5hc8 PRENYLTRANSFERENCE
FOR PROTEIN
(Lavandula
lanata) 		5 / 12 LEU A 246
PHE A 258
ILE A  75
ALA A 249
THR A 271
 None
 1.05A 2v0mC-5hc8A:
undetectable		 2v0mC-5hc8A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 5hc8 PRENYLTRANSFERENCE
FOR PROTEIN
(Lavandula
lanata) 		3 / 3 SER A 105
ARG A 106
GLN A 109
 None
 0.86A 2xnrA-5hc8A:
undetectable		 2xnrA-5hc8A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 5hc8 PRENYLTRANSFERENCE
FOR PROTEIN
(Lavandula
lanata) 		4 / 4 GLY A 163
TYR A 197
GLY A 198
ASP A 202
 None
 1.05A 3kl3A-5hc8A:
2.3		 3kl3A-5hc8A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 5hc8 PRENYLTRANSFERENCE
FOR PROTEIN
(Lavandula
lanata) 		4 / 7 ILE A  74
LEU A 260
THR A 235
ARG A 167
 ISY  A 405 (-4.7A)
None
None
None
 1.18A 3nxuA-5hc8A:
undetectable		 3nxuA-5hc8A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5hc8 PRENYLTRANSFERENCE
FOR PROTEIN
(Lavandula
lanata) 		5 / 12 ILE A 138
VAL A 151
PHE A 142
ILE A  75
ILE A 117
 None
 1.10A 3w68C-5hc8A:
undetectable		 3w68C-5hc8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5hc8 PRENYLTRANSFERENCE
FOR PROTEIN
(Lavandula
lanata) 		4 / 7 LEU A 135
TYR A 139
ILE A  75
GLY A  92
 61G  A 403 ( 4.5A)
None
None
None
 0.91A 4eq4A-5hc8A:
undetectable		 4eq4A-5hc8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5hc8 PRENYLTRANSFERENCE
FOR PROTEIN
(Lavandula
lanata) 		4 / 7 LEU A 135
TYR A 139
ILE A  75
GLY A  92
 61G  A 403 ( 4.5A)
None
None
None
 0.91A 4eqlA-5hc8A:
undetectable		 4eqlA-5hc8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5hc8 PRENYLTRANSFERENCE
FOR PROTEIN
(Lavandula
lanata) 		4 / 7 LEU A 135
TYR A 139
ILE A  75
GLY A  92
 61G  A 403 ( 4.5A)
None
None
None
 0.90A 4eqlB-5hc8A:
undetectable		 4eqlB-5hc8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5hc8 PRENYLTRANSFERENCE
FOR PROTEIN
(Lavandula
lanata) 		4 / 6 LEU A 135
TYR A 139
ILE A  75
GLY A  92
 61G  A 403 ( 4.5A)
None
None
None
 0.94A 4l39A-5hc8A:
undetectable		 4l39A-5hc8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5hc8 PRENYLTRANSFERENCE
FOR PROTEIN
(Lavandula
lanata) 		4 / 7 LEU A 135
TYR A 139
ILE A  75
GLY A  92
 61G  A 403 ( 4.5A)
None
None
None
 0.92A 4l39B-5hc8A:
undetectable		 4l39B-5hc8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 5hc8 PRENYLTRANSFERENCE
FOR PROTEIN
(Lavandula
lanata) 		3 / 3 SER A 145
ASP A 141
GLN A  94
 None
 0.67A 4oltA-5hc8A:
1.6
4oltB-5hc8A:
1.5		 4oltA-5hc8A:
21.50
4oltB-5hc8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 5hc8 PRENYLTRANSFERENCE
FOR PROTEIN
(Lavandula
lanata) 		3 / 3 GLN A  94
SER A 145
ASP A 141
 None
 0.70A 4qwpA-5hc8A:
1.6
4qwpB-5hc8A:
1.6		 4qwpA-5hc8A:
21.50
4qwpB-5hc8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 5hc8 PRENYLTRANSFERENCE
FOR PROTEIN
(Lavandula
lanata) 		4 / 6 ALA A 250
SER A  84
ASP A 277
PRO A 276
 None
 1.14A 5c6pA-5hc8A:
undetectable		 5c6pA-5hc8A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5hc8 PRENYLTRANSFERENCE
FOR PROTEIN
(Lavandula
lanata) 		4 / 7 HIS A 232
HIS A 216
ILE A 218
VAL A 214
 None
 1.28A 5kkzC-5hc8A:
undetectable
5kkzE-5hc8A:
undetectable		 5kkzC-5hc8A:
20.22
5kkzE-5hc8A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5hc8 PRENYLTRANSFERENCE
FOR PROTEIN
(Lavandula
lanata) 		4 / 7 HIS A 216
ILE A 218
VAL A 214
HIS A 232
 None
 1.29A 5kkzK-5hc8A:
undetectable
5kkzQ-5hc8A:
undetectable		 5kkzK-5hc8A:
20.53
5kkzQ-5hc8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5hc8 PRENYLTRANSFERENCE
FOR PROTEIN
(Lavandula
lanata) 		4 / 7 HIS A 232
HIS A 216
ILE A 218
VAL A 214
 None
 1.24A 5kkzM-5hc8A:
undetectable
5kkzO-5hc8A:
undetectable		 5kkzM-5hc8A:
20.22
5kkzO-5hc8A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5hc8 PRENYLTRANSFERENCE
FOR PROTEIN
(Lavandula
lanata) 		5 / 10 LEU A 283
ALA A 286
SER A 289
THR A 116
LEU A 246
 None
 1.08A 5m5cE-5hc8A:
undetectable		 5m5cE-5hc8A:
20.71