SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hca'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 5hca CALRETICULIN,CALRETI
CULIN
(Entamoeba
histolytica) 		4 / 8 HIS C  19
PHE C  18
ASP C 324
LEU C 326
 None
 1.02A 1e7cA-5hcaC:
undetectable		 1e7cA-5hcaC:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8D_A_CLWA906_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5hca CALRETICULIN,CALRETI
CULIN
(Entamoeba
histolytica) 		4 / 5 PRO C 128
VAL C 130
TYR C 165
GLU C 157
 None
 1.04A 1m8dA-5hcaC:
undetectable		 1m8dA-5hcaC:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8D_B_CLWB907_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5hca CALRETICULIN,CALRETI
CULIN
(Entamoeba
histolytica) 		4 / 5 PRO C 128
VAL C 130
TYR C 165
GLU C 157
 None
 1.07A 1m8dB-5hcaC:
undetectable		 1m8dB-5hcaC:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9J_A_CLWA906_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 5hca CALRETICULIN,CALRETI
CULIN
(Entamoeba
histolytica) 		4 / 5 PRO C 128
VAL C 130
TYR C 165
GLU C 157
 None
 1.02A 1m9jA-5hcaC:
undetectable		 1m9jA-5hcaC:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9J_B_CLWB907_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 5hca CALRETICULIN,CALRETI
CULIN
(Entamoeba
histolytica) 		4 / 5 PRO C 128
VAL C 130
TYR C 165
GLU C 157
 None
 1.06A 1m9jB-5hcaC:
0.3		 1m9jB-5hcaC:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 5hca CALRETICULIN,CALRETI
CULIN
(Entamoeba
histolytica) 		5 / 9 GLY C  94
LYS C  47
GLY C 319
GLY C  98
GLY C  99
 None
 1.11A 1mxdA-5hcaC:
undetectable		 1mxdA-5hcaC:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 5hca CALRETICULIN,CALRETI
CULIN
(Entamoeba
histolytica) 		4 / 6 ASP C  26
THR C  21
GLU C  20
GLU C  23
 None
 1.18A 2dttB-5hcaC:
undetectable
2dttC-5hcaC:
undetectable		 2dttB-5hcaC:
18.35
2dttC-5hcaC:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 5hca CALRETICULIN,CALRETI
CULIN
(Entamoeba
histolytica) 		5 / 11 VAL C 139
ILE C 327
LEU C  83
ILE C 124
THR C 137
 None
 0.93A 3clbA-5hcaC:
undetectable		 3clbA-5hcaC:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 5hca CALRETICULIN,CALRETI
CULIN
(Entamoeba
histolytica) 		5 / 12 VAL C 139
ILE C 327
LEU C  83
ILE C 124
THR C 137
 None
 0.93A 3clbC-5hcaC:
undetectable		 3clbC-5hcaC:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5hca CALRETICULIN,CALRETI
CULIN
(Entamoeba
histolytica) 		5 / 11 VAL C 139
ILE C 327
LEU C  83
ILE C 124
THR C 137
 None
 0.94A 3hbbC-5hcaC:
undetectable		 3hbbC-5hcaC:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5hca CALRETICULIN,CALRETI
CULIN
(Entamoeba
histolytica) 		4 / 8 TYR C 175
TRP C 193
LEU C 300
TYR C 303
 None
 0.93A 3v81C-5hcaC:
undetectable		 3v81C-5hcaC:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5hca CALRETICULIN,CALRETI
CULIN
(Entamoeba
histolytica) 		4 / 8 TYR C 175
TRP C 193
LEU C 300
TYR C 303
 None
 0.95A 4pwdC-5hcaC:
undetectable		 4pwdC-5hcaC:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 5hca CALRETICULIN,CALRETI
CULIN
(Entamoeba
histolytica) 		4 / 8 ILE C  95
VAL C 130
GLU C 157
CYH C 156
 None
 1.18A 5dqyA-5hcaC:
undetectable		 5dqyA-5hcaC:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 5hca CALRETICULIN,CALRETI
CULIN
(Entamoeba
histolytica) 		3 / 3 VAL C  16
TYR C  17
GLU C 337
 None
 0.99A 5zmqD-5hcaC:
undetectable
5zmqE-5hcaC:
undetectable		 5zmqD-5hcaC:
20.88
5zmqE-5hcaC:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 5hca CALRETICULIN,CALRETI
CULIN
(Entamoeba
histolytica) 		4 / 8 ARG C 136
THR C 137
PRO C 128
ILE C 179
 None
 1.13A 6a4iA-5hcaC:
undetectable		 6a4iA-5hcaC:
21.95