SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hcf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5hcf CALRETICULIN,
PUTATIVE,CALRETICULI
N, PUTATIVE
(Trypanosoma
cruzi) 		4 / 6 LEU A 146
VAL A  97
ILE A 110
ARG A 135
 None
 1.09A 1opjB-5hcfA:
undetectable		 1opjB-5hcfA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5hcf CALRETICULIN,
PUTATIVE,CALRETICULI
N, PUTATIVE
(Trypanosoma
cruzi) 		4 / 4 SER A 326
GLY A 325
GLY A 108
GLY A 106
 None
None
None
ACY  A 402 ( 4.1A)
 0.80A 3bogB-5hcfA:
undetectable
3bogD-5hcfA:
undetectable		 3bogB-5hcfA:
undetectable
3bogD-5hcfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5hcf CALRETICULIN,
PUTATIVE,CALRETICULI
N, PUTATIVE
(Trypanosoma
cruzi) 		4 / 8 TYR A  74
ASP A 134
GLN A 139
GLU A 163
 None
ACY  A 402 (-3.4A)
None
None
 1.43A 3dh0A-5hcfA:
undetectable		 3dh0A-5hcfA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5hcf CALRETICULIN,
PUTATIVE,CALRETICULI
N, PUTATIVE
(Trypanosoma
cruzi) 		4 / 8 ASN A 296
GLU A 205
ILE A 206
ASP A 208
 None
 1.10A 4d33A-5hcfA:
undetectable		 4d33A-5hcfA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5hcf CALRETICULIN,
PUTATIVE,CALRETICULI
N, PUTATIVE
(Trypanosoma
cruzi) 		4 / 7 ASN A 296
GLU A 205
ILE A 206
ASP A 208
 None
 1.12A 4d33B-5hcfA:
undetectable		 4d33B-5hcfA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 5hcf CALRETICULIN,
PUTATIVE,CALRETICULI
N, PUTATIVE
(Trypanosoma
cruzi) 		4 / 7 ILE A 317
THR A  68
SER A 324
LEU A  76
 None
 0.82A 5fukA-5hcfA:
undetectable
5fukB-5hcfA:
undetectable		 5fukA-5hcfA:
20.86
5fukB-5hcfA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 5hcf CALRETICULIN,
PUTATIVE,CALRETICULI
N, PUTATIVE
(Trypanosoma
cruzi) 		4 / 8 GLN A 321
ILE A 317
GLY A 107
LEU A 103
 None
None
ACY  A 402 ( 4.9A)
None
 0.94A 5hwaA-5hcfA:
undetectable		 5hwaA-5hcfA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5hcf CALRETICULIN,
PUTATIVE,CALRETICULI
N, PUTATIVE
(Trypanosoma
cruzi) 		5 / 9 LEU A  67
THR A  68
SER A  51
ILE A  50
ILE A 327
 None
 1.16A 6ebpA-5hcfA:
undetectable		 6ebpA-5hcfA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5hcf CALRETICULIN,
PUTATIVE,CALRETICULI
N, PUTATIVE
(Trypanosoma
cruzi) 		5 / 10 LEU A  67
THR A  68
SER A  51
ILE A  50
ILE A 327
 None
 1.19A 6ebpB-5hcfA:
undetectable		 6ebpB-5hcfA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5hcf CALRETICULIN,
PUTATIVE,CALRETICULI
N, PUTATIVE
(Trypanosoma
cruzi) 		5 / 10 LEU A  67
THR A  68
SER A  51
ILE A  50
ILE A 327
 None
 1.20A 6ebpC-5hcfA:
undetectable		 6ebpC-5hcfA:
13.62