SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hci'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 232
TYR A 229
ASN A 153
TYR A 137
 None
 1.35A 1afsA-5hciA:
undetectable		 1afsA-5hciA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 232
TYR A 229
ASN A 153
TYR A 137
 None
 1.35A 1afsB-5hciA:
undetectable		 1afsB-5hciA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 104
ILE A   6
LEU A  23
VAL A 252
VAL A 171
 None
 0.95A 2nnhA-5hciA:
undetectable		 2nnhA-5hciA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		5 / 12 THR A   5
PHE A 127
ARG A  91
ILE A  90
PHE A 131
 None
 1.29A 2vdyB-5hciA:
undetectable		 2vdyB-5hciA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		5 / 12 THR A   5
VAL A 134
ILE A 135
GLU A 125
PRO A 167
 None
 1.22A 2yzqA-5hciA:
undetectable		 2yzqA-5hciA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 157
LEU A 155
SER A 152
VAL A 170
 None
 1.06A 3d2tB-5hciA:
undetectable		 3d2tB-5hciA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 144
ASP A 200
GLN A 201
 None
 0.81A 3eeyC-5hciA:
undetectable		 3eeyC-5hciA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 144
ASP A 200
GLN A 201
 None
 0.80A 3eeyD-5hciA:
undetectable		 3eeyD-5hciA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 144
ASP A 200
GLN A 201
 None
 0.79A 3eeyE-5hciA:
undetectable		 3eeyE-5hciA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 109
ALA A  12
PRO A  41
ALA A  42
ILE A 111
 GDP  A 301 ( 4.4A)
GDP  A 301 ( 4.8A)
None
None
None
 0.93A 3jayA-5hciA:
undetectable		 3jayA-5hciA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 200
SER A 146
PHE A 193
LEU A 217
 None
 1.05A 3m0wE-5hciA:
undetectable
3m0wF-5hciA:
undetectable
3m0wG-5hciA:
undetectable
3m0wH-5hciA:
undetectable		 3m0wE-5hciA:
16.86
3m0wF-5hciA:
16.86
3m0wG-5hciA:
16.86
3m0wH-5hciA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		6 / 12 ASP A  40
GLY A 109
GLY A  15
PRO A  47
VAL A  46
VAL A  43
 None
GDP  A 301 ( 4.4A)
GDP  A 301 (-3.0A)
None
None
None
 1.40A 3ucbA-5hciA:
undetectable		 3ucbA-5hciA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		6 / 12 ASP A  40
GLY A 109
GLY A  15
PRO A  47
VAL A  46
VAL A  43
 None
GDP  A 301 ( 4.4A)
GDP  A 301 (-3.0A)
None
None
None
 1.32A 3ucbB-5hciA:
undetectable		 3ucbB-5hciA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR A  60
VAL A  63
SER A  78
GLY A  73
 None
 0.88A 3v4tA-5hciA:
undetectable
3v4tD-5hciA:
undetectable		 3v4tA-5hciA:
19.76
3v4tD-5hciA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 109
ILE A 111
GLY A  10
ILE A   9
 GDP  A 301 ( 4.4A)
None
None
None
 0.67A 4eatA-5hciA:
undetectable		 4eatA-5hciA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 193
ALA A 195
PHE A 190
LEU A 225
GLY A 212
 None
 1.26A 4kykA-5hciA:
undetectable
4kykB-5hciA:
undetectable		 4kykA-5hciA:
17.49
4kykB-5hciA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		4 / 6 MET A  20
ILE A  86
ILE A  90
VAL A  89
 None
 1.01A 4olmA-5hciA:
undetectable		 4olmA-5hciA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A  19
VAL A 252
LEU A  27
LEU A  23
 None
 1.00A 6e43A-5hciA:
undetectable		 6e43A-5hciA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A  19
VAL A 252
LEU A  27
LEU A  23
 None
 0.98A 6e43B-5hciA:
undetectable		 6e43B-5hciA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A  19
VAL A 252
LEU A  27
LEU A  23
 None
 0.97A 6e43C-5hciA:
undetectable		 6e43C-5hciA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5hci GPN-LOOP GTPASE 1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A  19
VAL A 252
LEU A  27
LEU A  23
 None
 1.02A 6e43D-5hciA:
undetectable		 6e43D-5hciA:
17.27