SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hd2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 11 THR A 298
THR A 261
THR A 285
ALA A 260
ALA A 281
 None
 1.18A 2f162-5hd2A:
undetectable		 2f162-5hd2A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 11 THR A 298
THR A 261
THR A 285
ALA A 260
ALA A 281
 None
 1.17A 2f16N-5hd2A:
undetectable		 2f16N-5hd2A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 VAL A 262
ALA A 260
PHE A  86
SER A  85
THR A 285
 None
 0.84A 2oipC-5hd2A:
undetectable		 2oipC-5hd2A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 VAL A 262
ALA A 260
PHE A  86
SER A  85
THR A 285
 None
 0.76A 3hj3C-5hd2A:
undetectable		 3hj3C-5hd2A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 10 THR A  41
VAL A  10
ILE A  14
ILE A  34
SER A  35
 None
 1.47A 3kpbD-5hd2A:
undetectable		 3kpbD-5hd2A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 11 ILE A   3
THR A 103
ASP A   5
ILE A 108
SER A 109
 None
 1.19A 3kpcA-5hd2A:
undetectable		 3kpcA-5hd2A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 THR A 298
THR A 261
THR A 285
ALA A 260
ALA A 281
 None
 1.19A 3mg02-5hd2A:
undetectable
3mg0V-5hd2A:
undetectable		 3mg02-5hd2A:
19.22
3mg0V-5hd2A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 11 THR A 298
THR A 261
THR A 285
ALA A 260
ALA A 281
 None
 1.17A 3mg0N-5hd2A:
undetectable		 3mg0N-5hd2A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		4 / 7 VAL A 254
ILE A 183
THR A 133
THR A 132
 None
 0.93A 3tneB-5hd2A:
undetectable		 3tneB-5hd2A:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		4 / 6 PHE A 122
ALA A 284
LEU A 286
THR A 285
 None
 1.02A 4dtzA-5hd2A:
undetectable		 4dtzA-5hd2A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 VAL A 262
ALA A 260
PHE A  86
SER A  85
THR A 285
 None
 1.02A 4eckA-5hd2A:
undetectable		 4eckA-5hd2A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 VAL A 262
ALA A 260
PHE A  86
SER A  85
THR A 285
 None
 0.93A 4eckB-5hd2A:
undetectable		 4eckB-5hd2A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		4 / 5 LEU A  62
GLY A 178
ILE A 120
GLN A  60
 None
 0.93A 4ma8C-5hd2A:
undetectable		 4ma8C-5hd2A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 9 ASN A 296
GLY A 289
THR A 261
ILE A 294
VAL A 297
 None
 1.09A 4nptA-5hd2A:
undetectable		 4nptA-5hd2A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		4 / 7 GLY A 179
GLN A  60
ALA A 256
ILE A 134
 None
 0.72A 4txnA-5hd2A:
undetectable		 4txnA-5hd2A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		4 / 7 GLY A 179
GLN A  60
ALA A 256
ILE A 134
 None
 0.74A 4txnB-5hd2A:
undetectable		 4txnB-5hd2A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		4 / 7 GLY A 179
GLN A  60
ALA A 256
ILE A 134
 None
 0.75A 4txnC-5hd2A:
undetectable		 4txnC-5hd2A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		4 / 7 GLY A 179
GLN A  60
ALA A 256
ILE A 134
 None
 0.72A 4txnD-5hd2A:
undetectable		 4txnD-5hd2A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		4 / 8 PHE A 225
SER A 222
TRP A 223
TYR A 203
 None
 1.41A 5amiB-5hd2A:
undetectable		 5amiB-5hd2A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 9 TYR A 259
ILE A 294
TYR A 280
GLU A 299
GLY A 124
 None
 1.38A 5ifuB-5hd2A:
undetectable		 5ifuB-5hd2A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 ILE A 183
VAL A 254
THR A  94
ASN A 137
GLU A 113
 None
 1.10A 5lg3E-5hd2A:
undetectable		 5lg3E-5hd2A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 10 ILE A 183
VAL A 254
THR A  94
ASN A 137
GLU A 113
 None
 1.11A 5lg3G-5hd2A:
undetectable		 5lg3G-5hd2A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 10 ILE A 183
VAL A 254
THR A  94
ASN A 137
GLU A 113
 None
 1.07A 5lg3H-5hd2A:
undetectable		 5lg3H-5hd2A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 ILE A 183
VAL A 254
THR A  94
ASN A 137
GLU A 113
 None
 1.19A 5lg3J-5hd2A:
undetectable		 5lg3J-5hd2A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 GLY A 126
SER A 293
ILE A 292
GLY A 128
GLY A 124
 None
 0.98A 5wyqB-5hd2A:
undetectable		 5wyqB-5hd2A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 5hd2 PARASPORAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		4 / 7 SER A 109
SER A 142
GLY A 101
LEU A 112
 None
 1.11A 6btxA-5hd2A:
undetectable		 6btxA-5hd2A:
21.00