SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hdf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		4 / 5 GLY B  74
LEU B  73
THR B  77
VAL B 154
 None
 1.03A 1ekjF-5hdfB:
undetectable
1ekjG-5hdfB:
undetectable		 1ekjF-5hdfB:
21.80
1ekjG-5hdfB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		4 / 7 GLY B 250
ASP B 259
HIS B 254
ALA B 258
 None
 0.99A 1gxsA-5hdfB:
8.8
1gxsB-5hdfB:
1.1		 1gxsA-5hdfB:
20.80
1gxsB-5hdfB:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		4 / 8 PHE B 132
VAL B  69
MET B  80
SER B 142
 None
 1.12A 1kb9A-5hdfB:
undetectable
1kb9C-5hdfB:
undetectable
1kb9D-5hdfB:
undetectable
1kb9E-5hdfB:
undetectable		 1kb9A-5hdfB:
22.37
1kb9C-5hdfB:
20.37
1kb9D-5hdfB:
20.47
1kb9E-5hdfB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		5 / 9 GLY B 101
ALA B 102
SER B 185
LEU B 186
HIS B 349
 None
 0.92A 1y7iA-5hdfB:
20.1		 1y7iA-5hdfB:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		5 / 12 THR B 207
GLY B 183
SER B 188
GLY B 101
VAL B 180
 None
 1.10A 2b25B-5hdfB:
undetectable		 2b25B-5hdfB:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		6 / 12 GLY B 305
ALA B 303
THR B 207
ALA B 208
ARG B 307
ALA B 347
 None
 1.46A 2gluB-5hdfB:
2.5		 2gluB-5hdfB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		3 / 3 ASP B 318
ASP B 306
ASP B 314
 None
 0.67A 2igtA-5hdfB:
2.2		 2igtA-5hdfB:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		4 / 6 ASP B 200
VAL B 163
PHE B 198
THR B 191
 None
 1.42A 2q6oB-5hdfB:
1.7		 2q6oB-5hdfB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		4 / 6 ARG B 237
THR B 246
ALA B 276
PRO B 249
 None
 1.15A 2ql8A-5hdfB:
undetectable
2ql8B-5hdfB:
undetectable		 2ql8A-5hdfB:
16.13
2ql8B-5hdfB:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		4 / 5 ILE B 296
SER B 293
PHE B 332
PRO B 290
 None
 1.20A 3bjwC-5hdfB:
undetectable		 3bjwC-5hdfB:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		5 / 12 GLY B 210
SER B 188
THR B 191
LEU B 304
ALA B 303
 None
 1.15A 3d91A-5hdfB:
undetectable		 3d91A-5hdfB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		5 / 12 ASN B 105
TRP B 109
GLY B 350
THR B 273
LEU B 353
 None
 1.23A 3iv6A-5hdfB:
2.6		 3iv6A-5hdfB:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		4 / 8 TYR B 108
LEU B 351
ALA B 303
SER B 364
 None
 0.95A 3rodA-5hdfB:
undetectable		 3rodA-5hdfB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		4 / 5 LEU B 351
MET B 301
THR B 207
PHE B 120
 None
 1.29A 3vasB-5hdfB:
4.9		 3vasB-5hdfB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		4 / 4 GLU B 155
GLY B 138
HIS B 100
ARG B 136
 None
 1.36A 4r82A-5hdfB:
undetectable
4r82B-5hdfB:
undetectable		 4r82A-5hdfB:
21.37
4r82B-5hdfB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		4 / 4 LYS B 274
ASP B 259
GLU B 271
THR B 247
 None
 0.91A 5d4uA-5hdfB:
2.2		 5d4uA-5hdfB:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		4 / 4 LYS B 274
ASP B 259
GLU B 271
THR B 247
 None
 0.90A 5d4uB-5hdfB:
2.1		 5d4uB-5hdfB:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		4 / 4 LYS B 274
ASP B 259
GLU B 271
THR B 247
 None
 0.86A 5d4uC-5hdfB:
2.2		 5d4uC-5hdfB:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		4 / 4 LYS B 274
ASP B 259
GLU B 271
THR B 247
 None
 0.92A 5d4uD-5hdfB:
2.2		 5d4uD-5hdfB:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		4 / 6 TYR B 104
ASP B 308
HIS B 349
TYR B 360
 None
 1.05A 5ih0A-5hdfB:
undetectable		 5ih0A-5hdfB:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		4 / 8 THR B 197
VAL B  99
GLY B 187
ARG B 136
 None
 0.98A 5nzyA-5hdfB:
undetectable		 5nzyA-5hdfB:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		5 / 12 GLU B 194
ASP B 200
LEU B 124
ALA B 203
GLY B 177
 None
 1.13A 5syeB-5hdfB:
3.1		 5syeB-5hdfB:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		5 / 12 PHE B 256
ILE B 221
LEU B 310
ALA B 102
LEU B 186
 None
 1.42A 5zwrB-5hdfB:
undetectable		 5zwrB-5hdfB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B50_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		5 / 12 PRO B 309
ASP B 308
LEU B 310
ASP B 270
MET B 262
 None
 1.28A 6b50A-5hdfB:
1.7		 6b50A-5hdfB:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 5hdf HYDROLASE
(Streptomyces
flocculus) 		4 / 5 ASN B 213
TYR B 184
GLY B 187
ASP B 308
 None
 1.26A 6gh9A-5hdfB:
undetectable		 6gh9A-5hdfB:
10.96