SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hdh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 11 ILE A 359
LEU A 413
ILE A 406
LEU A 401
ILE A 357
 None
 1.08A 1dhiB-5hdhA:
undetectable		 1dhiB-5hdhA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		6 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
ILE A 357
 None
 1.13A 1drbB-5hdhA:
undetectable		 1drbB-5hdhA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
 None
 1.04A 1dyiB-5hdhA:
undetectable		 1dyiB-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
 None
 1.13A 1jolB-5hdhA:
undetectable		 1jolB-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		4 / 5 ASP A 645
VAL A 614
SER A 592
ASP A 673
 None
NAG  A 912 (-4.6A)
NAG  A 912 ( 4.7A)
None
 1.16A 1n2xB-5hdhA:
undetectable		 1n2xB-5hdhA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		4 / 7 ILE A 496
GLU A 525
PHE A 544
ALA A 549
 None
 1.15A 1oniD-5hdhA:
undetectable
1oniE-5hdhA:
undetectable		 1oniD-5hdhA:
13.04
1oniE-5hdhA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		6 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
ILE A 357
 None
 1.13A 1ra2A-5hdhA:
undetectable		 1ra2A-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		6 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
ILE A 357
 None
 1.10A 1ra8A-5hdhA:
undetectable		 1ra8A-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		6 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
ILE A 357
 None
 1.13A 1rb2A-5hdhA:
undetectable		 1rb2A-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 ILE A 359
LEU A 413
PHE A 387
LEU A 401
ILE A 357
 None
 1.06A 1rb2B-5hdhA:
undetectable		 1rb2B-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		6 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
ILE A 357
 None
 1.13A 1rd7A-5hdhA:
undetectable		 1rd7A-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
ILE A 357
 None
 1.14A 1re7A-5hdhA:
undetectable		 1re7A-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
ILE A 357
 None
 1.11A 1re7B-5hdhA:
undetectable		 1re7B-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 ILE A 359
LEU A 413
PHE A 387
LEU A 401
ILE A 357
 None
 1.14A 1re7B-5hdhA:
undetectable		 1re7B-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
 None
 1.18A 1rh3A-5hdhA:
undetectable		 1rh3A-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		4 / 8 ASN A 404
GLN A 380
PHE A 405
ASN A 491
 None
 1.33A 1rs7B-5hdhA:
undetectable		 1rs7B-5hdhA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		6 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
ILE A 357
 None
 1.08A 1rx2A-5hdhA:
undetectable		 1rx2A-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
 None
 0.98A 1rx3A-5hdhA:
undetectable		 1rx3A-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		6 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
ILE A 357
 None
 1.07A 1rx7A-5hdhA:
undetectable		 1rx7A-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
 None
 0.98A 1rx8A-5hdhA:
undetectable		 1rx8A-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 LEU A 253
LEU A 294
LEU A 318
LEU A 289
MET A 310
 None
 1.45A 1sqnA-5hdhA:
undetectable		 1sqnA-5hdhA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 LEU A 542
LEU A 561
ASN A 564
LEU A 591
LEU A 535
 None
 1.41A 1sqnA-5hdhA:
undetectable		 1sqnA-5hdhA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 11 LEU A 714
ASN A 746
ILE A 724
LEU A 703
PHE A 731
 None
 1.09A 1tw4A-5hdhA:
undetectable		 1tw4A-5hdhA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 PHE A 242
LEU A 294
ILE A 276
ILE A 234
LEU A 292
 None
 1.08A 1xdkB-5hdhA:
undetectable		 1xdkB-5hdhA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 LEU A 589
LEU A 559
LEU A 535
LEU A 521
LEU A 577
 None
 1.23A 1zucB-5hdhA:
undetectable		 1zucB-5hdhA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		4 / 8 PHE A 363
LEU A 344
LEU A 339
LEU A 336
 None
 0.85A 2bfpA-5hdhA:
undetectable		 2bfpA-5hdhA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 10 ALA A 528
PHE A 526
LEU A 556
LEU A 550
LEU A 504
 None
 1.11A 2bxqA-5hdhA:
undetectable		 2bxqA-5hdhA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 LEU A 413
PHE A 417
LEU A 382
LEU A 401
ILE A 399
 None
 1.00A 2bxqA-5hdhA:
undetectable		 2bxqA-5hdhA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		4 / 5 LEU A 474
ILE A 422
LEU A 420
SER A 397
 None
 0.88A 2byoA-5hdhA:
undetectable		 2byoA-5hdhA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		4 / 8 ILE A 671
SER A 647
ASP A 645
LEU A 669
 None
 1.00A 2cdqA-5hdhA:
undetectable		 2cdqA-5hdhA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		4 / 7 SER A  71
ASP A  72
SER A  50
ASN A  93
 None
 1.15A 2cmlA-5hdhA:
undetectable		 2cmlA-5hdhA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		4 / 8 SER A  71
ASP A  72
SER A  50
ASN A  93
 None
 1.05A 2cmlB-5hdhA:
undetectable		 2cmlB-5hdhA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		4 / 8 SER A  71
ASP A  72
SER A  50
ASN A  93
 None
 1.16A 2cmlD-5hdhA:
undetectable		 2cmlD-5hdhA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		6 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
ILE A 357
 None
 1.10A 2d0kA-5hdhA:
undetectable		 2d0kA-5hdhA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		6 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
ILE A 357
 None
 1.11A 2d0kB-5hdhA:
undetectable		 2d0kB-5hdhA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		4 / 8 ILE A 671
LEU A 695
THR A 667
LEU A 690
 None
 0.85A 2eijN-5hdhA:
undetectable
2eijW-5hdhA:
undetectable		 2eijN-5hdhA:
19.75
2eijW-5hdhA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		4 / 8 ILE A 671
LEU A 695
THR A 667
LEU A 690
 None
 0.84A 2eikN-5hdhA:
undetectable
2eikW-5hdhA:
undetectable		 2eikN-5hdhA:
19.75
2eikW-5hdhA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		4 / 8 ILE A 671
LEU A 695
THR A 667
LEU A 690
 None
 0.88A 2eilN-5hdhA:
undetectable
2eilW-5hdhA:
undetectable		 2eilN-5hdhA:
19.75
2eilW-5hdhA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMQ_A_BEZA3_0
(PROTEIN NDRG2)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		4 / 7 TYR A 348
PHE A 320
ARG A 259
HIS A 450
 None
 1.32A 2qmqA-5hdhA:
undetectable		 2qmqA-5hdhA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		4 / 7 PHE A 568
LEU A 521
PHE A 526
ILE A 493
 None
 0.96A 2v0mC-5hdhA:
undetectable		 2v0mC-5hdhA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 SER A 152
PHE A  83
ILE A  92
ASN A  93
PHE A 121
 None
 1.44A 2vdyB-5hdhA:
undetectable		 2vdyB-5hdhA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 LEU A 253
LEU A 294
LEU A 318
LEU A 289
MET A 310
 None
 1.48A 2w8yB-5hdhA:
undetectable		 2w8yB-5hdhA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 LEU A 542
LEU A 561
ASN A 564
LEU A 591
LEU A 535
 None
 1.41A 2w8yB-5hdhA:
undetectable		 2w8yB-5hdhA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 LEU A 299
PHE A 307
ALA A 282
ALA A 305
ILE A 276
 None
 1.15A 3czhB-5hdhA:
undetectable		 3czhB-5hdhA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 LEU A 253
LEU A 294
LEU A 318
LEU A 289
MET A 310
 None
 1.47A 3d90A-5hdhA:
undetectable		 3d90A-5hdhA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 LEU A 542
LEU A 561
ASN A 564
LEU A 591
LEU A 535
 None
 1.37A 3d90A-5hdhA:
undetectable		 3d90A-5hdhA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 11 ASN A 698
ILE A 671
LEU A 669
PHE A 659
THR A 704
 None
 1.27A 3fl9C-5hdhA:
undetectable		 3fl9C-5hdhA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 9 ALA A 549
LEU A 542
ILE A 496
LEU A 512
PHE A 526
 None
 1.24A 3fl9H-5hdhA:
undetectable		 3fl9H-5hdhA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 11 ASN A 540
LEU A 537
LEU A 510
VAL A 532
ILE A 496
 None
 1.26A 3jw5A-5hdhA:
undetectable		 3jw5A-5hdhA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		4 / 7 LEU A 605
LEU A 589
SER A 592
THR A 538
 None
None
NAG  A 912 ( 4.7A)
NAG  A 912 ( 4.7A)
 1.05A 3lm8B-5hdhA:
undetectable
3lm8D-5hdhA:
undetectable		 3lm8B-5hdhA:
14.66
3lm8D-5hdhA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		3 / 3 LYS A  91
ARG A 128
ASP A  43
 None
 1.43A 3o7wA-5hdhA:
undetectable		 3o7wA-5hdhA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		3 / 3 ASP A 694
GLU A 768
SER A 616
 None
 0.60A 3p2kA-5hdhA:
undetectable		 3p2kA-5hdhA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
 None
 1.08A 3ql0A-5hdhA:
undetectable		 3ql0A-5hdhA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		3 / 3 GLN A 284
THR A 287
ASN A 285
 NAG  A 901 ( 2.9A)
None
NAG  A 901 (-1.6A)
 0.82A 3v4tE-5hdhA:
undetectable		 3v4tE-5hdhA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		3 / 3 LEU A 767
MET A 787
ASP A 782
 None
 0.75A 3v5wA-5hdhA:
undetectable		 3v5wA-5hdhA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		4 / 5 PHE A 774
LEU A 767
ILE A 814
VAL A 815
 None
 0.82A 3wrkA-5hdhA:
undetectable		 3wrkA-5hdhA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		6 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
ILE A 357
 None
 1.16A 4ej1A-5hdhA:
undetectable		 4ej1A-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		6 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
ILE A 357
 None
 1.17A 4fhbA-5hdhA:
undetectable		 4fhbA-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD305_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		4 / 4 ILE A 751
LEU A 748
LYS A 749
ASN A 752
 None
 1.07A 4g19D-5hdhA:
undetectable		 4g19D-5hdhA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 LEU A 521
ALA A 549
ILE A 596
LEU A 591
HIS A 575
 None
 1.17A 4j24D-5hdhA:
undetectable		 4j24D-5hdhA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 10 ILE A 166
PHE A 197
THR A 190
LEU A 213
ILE A 161
 None
 1.29A 4km0A-5hdhA:
undetectable		 4km0A-5hdhA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 ILE A 166
PHE A 197
LEU A 213
LEU A 208
ILE A 161
 None
 1.05A 4km2B-5hdhA:
undetectable		 4km2B-5hdhA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		4 / 6 ILE A 399
ILE A 359
PHE A 417
LEU A 413
 None
 0.96A 4m51A-5hdhA:
undetectable		 4m51A-5hdhA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 LEU A 413
PHE A 387
ILE A 406
LEU A 401
ILE A 357
 None
 1.06A 4nx6A-5hdhA:
undetectable		 4nx6A-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 LEU A 413
PHE A 387
ILE A 406
LEU A 401
ILE A 357
 None
 1.10A 4nx7A-5hdhA:
undetectable		 4nx7A-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		6 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
ILE A 357
 None
 1.18A 4p3rA-5hdhA:
undetectable		 4p3rA-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		6 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
ILE A 357
 None
 1.18A 4pssA-5hdhA:
undetectable		 4pssA-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 LEU A 413
PHE A 387
ILE A 406
LEU A 401
ILE A 357
 None
 1.08A 4pstA-5hdhA:
undetectable		 4pstA-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
ILE A 357
 None
 1.17A 4ptjA-5hdhA:
undetectable		 4ptjA-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 11 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
 None
 1.11A 4qlfA-5hdhA:
undetectable		 4qlfA-5hdhA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
 None
 1.11A 4qlgA-5hdhA:
undetectable		 4qlgA-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 PHE A 332
ILE A 327
LEU A 323
LEU A 292
LEU A 316
 None
 1.48A 4qynB-5hdhA:
undetectable		 4qynB-5hdhA:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		3 / 3 ARG A 630
GLU A 578
TYR A 631
 None
 0.98A 4r29D-5hdhA:
undetectable		 4r29D-5hdhA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 9 ILE A 403
GLU A 427
LEU A 486
LEU A 474
ILE A 422
 None
 1.31A 4r38C-5hdhA:
undetectable		 4r38C-5hdhA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
 None
 1.06A 4rgcA-5hdhA:
undetectable		 4rgcA-5hdhA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
 None
 1.08A 4x5fA-5hdhA:
undetectable		 4x5fA-5hdhA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
 None
 1.07A 4x5fB-5hdhA:
undetectable		 4x5fB-5hdhA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 12 PHE A 579
ILE A 496
LEU A 561
LEU A 559
LEU A 535
 None
 1.24A 4xumA-5hdhA:
undetectable		 4xumA-5hdhA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		3 / 3 ALA A 658
ASN A 661
LEU A 662
 None
 0.26A 5i1oC-5hdhA:
undetectable		 5i1oC-5hdhA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		3 / 3 ALA A 658
ASN A 661
LEU A 662
 None
 0.30A 5i1pA-5hdhA:
undetectable		 5i1pA-5hdhA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		4 / 8 HIS A 593
ASN A 590
LEU A 613
SER A 647
 None
NAG  A 912 (-2.4A)
None
None
 1.02A 5m8rB-5hdhA:
undetectable		 5m8rB-5hdhA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		4 / 8 HIS A 593
ASN A 590
LEU A 613
SER A 647
 None
NAG  A 912 (-2.4A)
None
None
 1.01A 5m8rD-5hdhA:
undetectable		 5m8rD-5hdhA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		6 / 12 ILE A 359
LEU A 413
PHE A 387
ILE A 406
LEU A 401
ILE A 357
 None
 1.15A 5z6jA-5hdhA:
undetectable		 5z6jA-5hdhA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		5 / 11 ILE A 359
LEU A 413
PHE A 387
LEU A 401
ILE A 357
 None
 1.02A 5z6mA-5hdhA:
undetectable		 5z6mA-5hdhA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		4 / 7 ILE A 671
LEU A 695
THR A 667
LEU A 690
 None
 0.88A 6nmfA-5hdhA:
undetectable
6nmfJ-5hdhA:
undetectable		 6nmfA-5hdhA:
19.75
6nmfJ-5hdhA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		4 / 7 ILE A 671
LEU A 695
THR A 667
LEU A 690
 None
 0.79A 6nmpA-5hdhA:
undetectable
6nmpJ-5hdhA:
undetectable		 6nmpA-5hdhA:
19.75
6nmpJ-5hdhA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens) 		4 / 5 ILE A 671
LEU A 695
THR A 667
LEU A 690
 None
 0.76A 6nmpN-5hdhA:
undetectable
6nmpW-5hdhA:
undetectable		 6nmpN-5hdhA:
19.75
6nmpW-5hdhA:
6.64