SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hdi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 5hdi CYTOCHROME P450 144
(Mycobacterium
tuberculosis) 		5 / 10 GLU A 186
ALA A 155
LEU A 179
GLU A 395
LEU A 391
 None
None
None
None
HEM  A 501 ( 4.5A)
 1.49A 1a29A-5hdiA:
undetectable		 1a29A-5hdiA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 5hdi CYTOCHROME P450 144
(Mycobacterium
tuberculosis) 		5 / 10 GLU A 314
GLU A 313
ALA A 310
LEU A 283
GLU A 319
 None
None
None
HEM  A 501 ( 4.1A)
None
 1.20A 1a29A-5hdiA:
undetectable		 1a29A-5hdiA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 5hdi CYTOCHROME P450 144
(Mycobacterium
tuberculosis) 		5 / 11 PHE A  71
GLU A 210
ILE A 422
LEU A 349
GLY A 324
 None
 1.32A 1hvyC-5hdiA:
undetectable		 1hvyC-5hdiA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5hdi CYTOCHROME P450 144
(Mycobacterium
tuberculosis) 		5 / 12 THR A 280
SER A 279
PHE A 322
VAL A 136
VAL A 184
 HEM  A 501 (-4.3A)
HEM  A 501 (-3.3A)
HEM  A 501 (-4.6A)
None
None
 1.25A 1q23B-5hdiA:
undetectable		 1q23B-5hdiA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5hdi CYTOCHROME P450 144
(Mycobacterium
tuberculosis) 		5 / 12 THR A 280
SER A 279
PHE A 322
VAL A 136
VAL A 184
 HEM  A 501 (-4.3A)
HEM  A 501 (-3.3A)
HEM  A 501 (-4.6A)
None
None
 1.23A 1q23C-5hdiA:
undetectable		 1q23C-5hdiA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5hdi CYTOCHROME P450 144
(Mycobacterium
tuberculosis) 		5 / 11 THR A 280
SER A 279
PHE A 322
VAL A 136
VAL A 184
 HEM  A 501 (-4.3A)
HEM  A 501 (-3.3A)
HEM  A 501 (-4.6A)
None
None
 1.24A 1q23I-5hdiA:
undetectable		 1q23I-5hdiA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5hdi CYTOCHROME P450 144
(Mycobacterium
tuberculosis) 		5 / 11 THR A 280
SER A 279
PHE A 322
VAL A 136
VAL A 184
 HEM  A 501 (-4.3A)
HEM  A 501 (-3.3A)
HEM  A 501 (-4.6A)
None
None
 1.27A 1q23J-5hdiA:
undetectable		 1q23J-5hdiA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5hdi CYTOCHROME P450 144
(Mycobacterium
tuberculosis) 		5 / 11 THR A 280
SER A 279
PHE A 322
VAL A 136
VAL A 184
 HEM  A 501 (-4.3A)
HEM  A 501 (-3.3A)
HEM  A 501 (-4.6A)
None
None
 1.26A 1q23L-5hdiA:
undetectable		 1q23L-5hdiA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 5hdi CYTOCHROME P450 144
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 272
PHE A 273
GLY A 277
THR A 280
 None
None
None
HEM  A 501 (-4.3A)
 0.87A 2bdmA-5hdiA:
13.9		 2bdmA-5hdiA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		 5hdi CYTOCHROME P450 144
(Mycobacterium
tuberculosis) 		4 / 5 GLY A 285
TRP A 171
TRP A 289
LEU A 430
 None
 1.39A 2j2pD-5hdiA:
undetectable
2j2pF-5hdiA:
undetectable		 2j2pD-5hdiA:
17.89
2j2pF-5hdiA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 5hdi CYTOCHROME P450 144
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 204
ILE A 232
LEU A 190
PRO A 191
PHE A 273
 None
 0.98A 2qk8A-5hdiA:
undetectable		 2qk8A-5hdiA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5hdi CYTOCHROME P450 144
(Mycobacterium
tuberculosis) 		5 / 12 THR A 280
SER A 279
PHE A 322
VAL A 136
VAL A 184
 HEM  A 501 (-4.3A)
HEM  A 501 (-3.3A)
HEM  A 501 (-4.6A)
None
None
 1.24A 3u9fB-5hdiA:
undetectable
3u9fC-5hdiA:
undetectable		 3u9fB-5hdiA:
19.26
3u9fC-5hdiA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5hdi CYTOCHROME P450 144
(Mycobacterium
tuberculosis) 		5 / 12 HIS A 325
HIS A 376
GLY A 351
GLY A 324
GLY A 375
 HEM  A 501 (-3.6A)
None
None
None
None
 1.18A 4blvB-5hdiA:
undetectable		 4blvB-5hdiA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5hdi CYTOCHROME P450 144
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 189
LEU A 391
PHE A 151
MET A 148
LEU A 198
 None
HEM  A 501 ( 4.5A)
None
None
None
 1.31A 4xldA-5hdiA:
1.8		 4xldA-5hdiA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 5hdi CYTOCHROME P450 144
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 377
TRP A  77
ASP A  78
SER A  62
 None
 1.41A 5nr3A-5hdiA:
undetectable		 5nr3A-5hdiA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5hdi CYTOCHROME P450 144
(Mycobacterium
tuberculosis) 		4 / 6 ASN A 304
LEU A 307
ARG A 397
GLY A 309
 None
 1.14A 5o4yA-5hdiA:
undetectable		 5o4yA-5hdiA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5hdi CYTOCHROME P450 144
(Mycobacterium
tuberculosis) 		4 / 5 TYR A  54
ASP A 356
PRO A 357
ALA A 353
 None
 0.97A 5otrA-5hdiA:
undetectable		 5otrA-5hdiA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5hdi CYTOCHROME P450 144
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 410
LEU A 404
ASP A 405
LEU A 430
GLY A 309
 None
 1.10A 5uxdB-5hdiA:
undetectable		 5uxdB-5hdiA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5hdi CYTOCHROME P450 144
(Mycobacterium
tuberculosis) 		5 / 10 TRP A 171
ILE A 169
ILE A 312
LEU A 284
ALA A 281
 None
 1.41A 5zjiB-5hdiA:
undetectable		 5zjiB-5hdiA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 5hdi CYTOCHROME P450 144
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  85
ILE A  84
ASP A 125
HIS A 129
 None
None
None
HEM  A 501 (-3.8A)
 0.92A 6ag0A-5hdiA:
undetectable		 6ag0A-5hdiA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5hdi CYTOCHROME P450 144
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 316
THR A 280
GLU A 313
LEU A 400
PHE A 379
 None
HEM  A 501 (-4.3A)
None
None
HEM  A 501 (-4.5A)
 1.22A 6aphA-5hdiA:
undetectable		 6aphA-5hdiA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5hdi CYTOCHROME P450 144
(Mycobacterium
tuberculosis) 		4 / 5 ARG A 238
ALA A 239
GLN A 235
ILE A 232
 None
 1.22A 6f6sA-5hdiA:
undetectable
6f6sB-5hdiA:
undetectable		 6f6sA-5hdiA:
11.14
6f6sB-5hdiA:
14.68