SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hdt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 10 ALA A 735
LEU A 776
ILE A 747
HIS A 715
LEU A 714
 None
 1.44A 1a52A-5hdtA:
undetectable		 1a52A-5hdtA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 10 ALA A 735
LEU A 776
ILE A 747
HIS A 715
LEU A 714
 None
 1.47A 1a52B-5hdtA:
undetectable		 1a52B-5hdtA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 9 ALA A 735
LEU A 776
ILE A 747
HIS A 715
LEU A 714
 None
 1.49A 1ereA-5hdtA:
undetectable		 1ereA-5hdtA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		4 / 5 LYS A1031
GLU A1033
ALA A1030
LEU A1028
 None
 1.13A 1eta1-5hdtA:
undetectable		 1eta1-5hdtA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		4 / 5 LYS A1031
GLU A1033
ALA A1030
LEU A1028
 None
 1.16A 1eta2-5hdtA:
undetectable		 1eta2-5hdtA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		4 / 6 LYS A1031
GLU A1033
ALA A1030
LEU A1028
 None
 1.13A 1etb1-5hdtA:
undetectable		 1etb1-5hdtA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		4 / 6 TYR A 419
VAL A 393
ILE A 374
LEU A 383
 None
 1.28A 1j96A-5hdtA:
undetectable		 1j96A-5hdtA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_2
(BILE ACID RECEPTOR)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		4 / 5 HIS A  71
ARG A  77
ILE A  87
HIS A  62
 None
 1.46A 1osvB-5hdtA:
undetectable		 1osvB-5hdtA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 12 LEU A 355
VAL A 385
ILE A 382
TRP A 435
LEU A 412
 None
 1.10A 1s19A-5hdtA:
undetectable		 1s19A-5hdtA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		4 / 6 LEU A 650
GLU A 686
ALA A 688
LEU A 653
 None
 1.18A 1sn5A-5hdtA:
undetectable		 1sn5A-5hdtA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		4 / 8 TYR A 128
PHE A 129
GLY A 116
THR A 160
 None
 1.03A 1ykiA-5hdtA:
undetectable
1ykiB-5hdtA:
undetectable		 1ykiA-5hdtA:
12.26
1ykiB-5hdtA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		4 / 5 LEU A 605
PRO A 610
ALA A 609
ILE A 608
 None
 1.00A 2aofB-5hdtA:
undetectable		 2aofB-5hdtA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 12 LEU A 797
VAL A 789
GLY A 771
VAL A 768
ILE A 793
 None
 1.06A 2f8gA-5hdtA:
undetectable		 2f8gA-5hdtA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 12 ILE A1076
SER A1078
ILE A1075
VAL A1044
LEU A1112
 None
 1.05A 2ft9A-5hdtA:
undetectable		 2ft9A-5hdtA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		4 / 5 LEU A 262
LEU A 196
ILE A 229
ALA A 218
 None
 0.71A 2i2zA-5hdtA:
3.9		 2i2zA-5hdtA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 11 ILE A 233
LEU A 277
ASN A 311
LEU A 262
ILE A 259
 None
 1.40A 3a50B-5hdtA:
undetectable		 3a50B-5hdtA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		6 / 12 LEU A 945
LEU A 998
ALA A 958
MET A 940
ALA A 941
VAL A 991
 None
 1.46A 3b0wA-5hdtA:
undetectable		 3b0wA-5hdtA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 12 LEU A 998
ALA A 958
MET A 940
ALA A 941
VAL A 991
 None
 1.25A 3b0wB-5hdtA:
undetectable		 3b0wB-5hdtA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 12 TYR A 478
ILE A 622
LEU A 650
ALA A 648
ILE A 613
 None
 1.06A 3b2rA-5hdtA:
undetectable		 3b2rA-5hdtA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 11 TYR A 478
ILE A 622
LEU A 650
ALA A 648
ILE A 613
 None
 1.08A 3b2rB-5hdtA:
undetectable		 3b2rB-5hdtA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		4 / 5 LEU A 621
ILE A 613
ILE A 622
GLY A 649
 None
 0.93A 3bufA-5hdtA:
undetectable		 3bufA-5hdtA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 12 THR A 198
LEU A 221
ILE A 233
ILE A 229
LEU A 251
 None
 1.25A 3gwxA-5hdtA:
undetectable		 3gwxA-5hdtA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 12 LEU A 836
ARG A 834
GLY A 847
THR A 848
SER A 849
 None
IHP  A1201 (-3.7A)
None
None
None
 1.06A 3okxA-5hdtA:
undetectable		 3okxA-5hdtA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 12 LEU A 836
ARG A 834
GLY A 847
THR A 848
SER A 849
 None
IHP  A1201 (-3.7A)
None
None
None
 1.30A 3okxB-5hdtA:
undetectable		 3okxB-5hdtA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 10 LEU A 797
VAL A 789
GLY A 771
VAL A 768
ILE A 793
 None
 1.00A 3oxwB-5hdtA:
undetectable		 3oxwB-5hdtA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 12 LEU A 797
VAL A 789
GLY A 771
VAL A 768
ILE A 793
 None
 0.98A 3oxxA-5hdtA:
undetectable		 3oxxA-5hdtA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 10 ASN A 151
PHE A 154
GLY A 188
PHE A 145
ASN A 142
 None
 1.36A 3r6wA-5hdtA:
undetectable
3r6wB-5hdtA:
undetectable		 3r6wA-5hdtA:
10.93
3r6wB-5hdtA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 12 VAL A  39
PHE A  42
HIS A  97
ILE A 106
LEU A 131
 None
 1.20A 3sp9B-5hdtA:
undetectable		 3sp9B-5hdtA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 12 LEU A  35
VAL A  80
PHE A  68
PHE A  42
CYH A  83
 None
 1.16A 3u9fB-5hdtA:
undetectable
3u9fC-5hdtA:
undetectable		 3u9fB-5hdtA:
11.48
3u9fC-5hdtA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 12 PHE A  42
CYH A  83
LEU A  35
VAL A  80
PHE A  68
 None
 1.15A 3u9fJ-5hdtA:
undetectable
3u9fL-5hdtA:
undetectable		 3u9fJ-5hdtA:
11.48
3u9fL-5hdtA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 12 PHE A  42
CYH A  83
LEU A  35
VAL A  80
PHE A  68
 None
 1.18A 3u9fP-5hdtA:
undetectable
3u9fS-5hdtA:
undetectable		 3u9fP-5hdtA:
11.48
3u9fS-5hdtA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		4 / 5 ARG A 289
LEU A 281
VAL A 292
ASP A 324
 None
 1.11A 3ufnA-5hdtA:
undetectable
3ufnB-5hdtA:
undetectable		 3ufnA-5hdtA:
6.05
3ufnB-5hdtA:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 12 LEU A 604
ILE A 449
ILE A 532
ASP A 538
ALA A 542
 None
 1.22A 3uj7A-5hdtA:
undetectable		 3uj7A-5hdtA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 12 LEU A 604
ILE A 449
ILE A 532
ASP A 538
ALA A 542
 None
 1.22A 3uj7B-5hdtA:
undetectable		 3uj7B-5hdtA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		4 / 7 THR A 550
LEU A 605
GLN A 499
LEU A 502
 None
 1.13A 4ib4A-5hdtA:
3.6		 4ib4A-5hdtA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		3 / 3 LYS A 948
LEU A 945
ALA A 947
 None
 0.60A 4ikiA-5hdtA:
undetectable		 4ikiA-5hdtA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		4 / 7 LEU A 785
ARG A 834
SER A 754
VAL A 768
 None
IHP  A1201 (-3.7A)
None
None
 1.15A 4klrA-5hdtA:
undetectable		 4klrA-5hdtA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		3 / 3 VAL A 818
SER A 819
THR A 822
 None
 0.15A 4luhA-5hdtA:
3.2		 4luhA-5hdtA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		3 / 3 PRO A 661
ASN A 500
HIS A 504
 None
 0.66A 4ma3H-5hdtA:
undetectable
4ma3L-5hdtA:
undetectable		 4ma3H-5hdtA:
10.82
4ma3L-5hdtA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 12 LEU A 536
PHE A 549
MET A 546
LEU A 510
LEU A 566
 None
 1.40A 4o8fB-5hdtA:
undetectable		 4o8fB-5hdtA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		4 / 8 ILE A1047
LYS A1048
ILE A 996
ALA A1072
 None
 0.94A 4ou1A-5hdtA:
undetectable		 4ou1A-5hdtA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		3 / 3 VAL A 640
TYR A 479
ALA A 482
 None
 0.51A 4ybnA-5hdtA:
undetectable		 4ybnA-5hdtA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		3 / 3 ARG A 607
TYR A 444
GLU A 456
 None
 0.60A 4zzbE-5hdtA:
2.8		 4zzbE-5hdtA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 12 ILE A 793
LEU A 854
VAL A 833
LEU A 788
THR A 850
 None
 1.11A 5bykA-5hdtA:
undetectable		 5bykA-5hdtA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		4 / 4 VAL A1017
ALA A 944
ILE A 996
THR A 995
 None
 1.10A 5e4dB-5hdtA:
undetectable		 5e4dB-5hdtA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 12 ILE A 829
ALA A 828
GLY A 862
LEU A 797
GLY A 883
 None
 0.96A 5i73A-5hdtA:
2.6		 5i73A-5hdtA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJD_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 9 LEU A 195
LEU A 161
ILE A 265
ILE A 185
LEU A 203
 None
 1.34A 5ljdA-5hdtA:
undetectable		 5ljdA-5hdtA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 10 LEU A 858
HIS A 859
GLY A 862
LEU A 854
ALA A 882
 None
 1.07A 5o96C-5hdtA:
undetectable
5o96D-5hdtA:
undetectable		 5o96C-5hdtA:
13.64
5o96D-5hdtA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 12 MET A 495
VAL A 489
SER A 617
LEU A 621
HIS A 660
 None
 1.27A 5ubbA-5hdtA:
undetectable		 5ubbA-5hdtA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		4 / 5 LEU A1021
ALA A 944
LEU A 945
LEU A 962
 None
 0.84A 5vkqA-5hdtA:
2.0
5vkqD-5hdtA:
2.1		 5vkqA-5hdtA:
21.61
5vkqD-5hdtA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		4 / 5 LEU A 962
LEU A1021
ALA A 944
LEU A 945
 None
 0.85A 5vkqA-5hdtA:
2.0
5vkqB-5hdtA:
2.0		 5vkqA-5hdtA:
21.61
5vkqB-5hdtA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		4 / 5 LEU A 962
LEU A1021
ALA A 944
LEU A 945
 None
 0.88A 5vkqC-5hdtA:
2.5
5vkqD-5hdtA:
2.1		 5vkqC-5hdtA:
21.61
5vkqD-5hdtA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 12 LEU A 536
PHE A 549
MET A 546
LEU A 510
LEU A 566
 None
 1.22A 5y2oA-5hdtA:
undetectable		 5y2oA-5hdtA:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		5 / 12 ILE A 793
LEU A 854
VAL A 833
LEU A 788
THR A 850
 None
 1.13A 6b54A-5hdtA:
undetectable		 6b54A-5hdtA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens) 		4 / 8 LEU A 553
VAL A 529
LEU A 509
ILE A 532
 None
 0.93A 6cb4A-5hdtA:
undetectable		 6cb4A-5hdtA:
17.22