SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hee'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN
(Thermococcus
kodakarensis) 		5 / 10 LEU A 136
VAL A 169
GLY A 232
VAL A  43
ILE A  45
 None
 1.00A 1hsgA-5heeA:
undetectable		 1hsgA-5heeA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN
(Thermococcus
kodakarensis) 		5 / 12 VAL A 169
VAL A  89
LEU A 167
LEU A 154
LEU A  85
 None
 1.21A 1mx1E-5heeA:
undetectable		 1mx1E-5heeA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN
(Thermococcus
kodakarensis) 		5 / 9 LEU A 136
VAL A 169
GLY A 232
VAL A  43
ILE A  45
 None
 0.97A 1ohrB-5heeA:
undetectable		 1ohrB-5heeA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN
(Thermococcus
kodakarensis) 		5 / 11 LEU A 136
VAL A 169
GLY A 232
VAL A  43
ILE A  45
 None
 0.80A 1t3rB-5heeA:
undetectable		 1t3rB-5heeA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN
(Thermococcus
kodakarensis) 		5 / 9 LEU A 136
VAL A 169
GLY A 232
VAL A  43
ILE A  45
 None
 0.90A 2o4pB-5heeA:
undetectable		 2o4pB-5heeA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN
(Thermococcus
kodakarensis) 		4 / 7 VAL A 157
VAL A 134
ASP A  82
VAL A  43
 None
 0.81A 2qbnA-5heeA:
undetectable		 2qbnA-5heeA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN
(Thermococcus
kodakarensis) 		5 / 10 LEU A 136
VAL A 169
GLY A 232
VAL A  43
ILE A  45
 None
 1.01A 3oxwD-5heeA:
undetectable		 3oxwD-5heeA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_1
(HIV-1 PROTEASE)		 5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN
(Thermococcus
kodakarensis) 		5 / 11 LEU A 136
VAL A 169
GLY A 232
VAL A  43
ILE A  45
 None
 0.90A 3oy4A-5heeA:
undetectable		 3oy4A-5heeA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN
(Thermococcus
kodakarensis) 		4 / 8 PHE A 252
HIS A 173
GLY A 253
GLY A 120
 None
 0.96A 3v3nB-5heeA:
undetectable		 3v3nB-5heeA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN
(Thermococcus
kodakarensis) 		4 / 8 PHE A 252
HIS A 173
GLY A 253
GLY A 120
 None
 0.96A 3v3nC-5heeA:
undetectable		 3v3nC-5heeA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN
(Thermococcus
kodakarensis) 		5 / 11 LEU A 136
VAL A 169
GLY A 232
VAL A  43
ILE A  45
 None
 0.90A 4dqeA-5heeA:
undetectable		 4dqeA-5heeA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN
(Thermococcus
kodakarensis) 		5 / 11 LEU A 136
VAL A 169
GLY A 232
VAL A  43
ILE A  45
 None
 0.83A 4dqhA-5heeA:
undetectable		 4dqhA-5heeA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN
(Thermococcus
kodakarensis) 		5 / 12 ALA A 176
TYR A 183
PHE A  70
PHE A 252
GLY A 174
 None
 1.17A 4mm6A-5heeA:
undetectable		 4mm6A-5heeA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN
(Thermococcus
kodakarensis) 		3 / 3 GLN A  62
HIS A  63
ARG A 111
 None
 0.85A 4qyqA-5heeA:
undetectable		 4qyqA-5heeA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN
(Thermococcus
kodakarensis) 		3 / 3 GLN A  62
HIS A  63
ARG A 111
 None
 0.76A 4qyqB-5heeA:
undetectable		 4qyqB-5heeA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN
(Thermococcus
kodakarensis) 		3 / 3 THR A 118
HIS A  55
LEU A 103
 None
ZN  A1003 (-3.2A)
None
 0.79A 5axdA-5heeA:
undetectable		 5axdA-5heeA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN
(Thermococcus
kodakarensis) 		4 / 8 LEU A  64
LEU A  44
ILE A  52
THR A 137
 None
 0.96A 5ljbA-5heeA:
undetectable		 5ljbA-5heeA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN
(Thermococcus
kodakarensis) 		4 / 4 ASP A 172
HIS A  10
HIS A  48
HIS A 175
 ZN  A1001 ( 4.5A)
ZN  A1001 (-3.2A)
ZN  A1001 (-3.3A)
ZN  A1001 ( 4.8A)
 1.09A 5ncdD-5heeA:
undetectable		 5ncdD-5heeA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN
(Thermococcus
kodakarensis) 		4 / 8 THR A 137
LEU A 136
THR A 100
VAL A 153
 None
 1.28A 5ov9B-5heeA:
undetectable		 5ov9B-5heeA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN
(Thermococcus
kodakarensis) 		3 / 3 TYR A 224
PRO A 212
LEU A 215
 None
 0.84A 6beoA-5heeA:
undetectable		 6beoA-5heeA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EUQ_A_DXCA502_0
(MULTIDRUG
TRANSPORTER MDFA)		 5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN
(Thermococcus
kodakarensis) 		5 / 11 ASN A  49
LEU A 117
GLY A  72
PRO A  47
GLN A 126
 None
 1.42A 6euqA-5heeA:
undetectable		 6euqA-5heeA:
19.76