SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hei'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 5hei NFRA2
(Bacillus
megaterium) 		4 / 8 PHE A  83
LEU A  97
GLY A 102
ASP A 101
 None
 0.93A 1rmtC-5heiA:
undetectable		 1rmtC-5heiA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 5hei NFRA2
(Bacillus
megaterium) 		4 / 7 LEU A  97
VAL A  99
THR A 100
ASP A  82
 None
 0.92A 2qblA-5heiA:
undetectable		 2qblA-5heiA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 5hei NFRA2
(Bacillus
megaterium) 		4 / 8 LEU A  97
ARG A  85
VAL A 108
GLY A 109
 None
 0.75A 2qd5B-5heiA:
undetectable		 2qd5B-5heiA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z71_A_PNVA903_1
(PENICILLIN ACYLASE)		 5hei NFRA2
(Bacillus
megaterium) 		5 / 10 THR A 111
GLU A 104
ASP A 112
GLY A  43
GLN A  45
 None
 1.27A 2z71A-5heiA:
undetectable
2z71C-5heiA:
undetectable		 2z71A-5heiA:
21.89
2z71C-5heiA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 5hei NFRA2
(Bacillus
megaterium) 		3 / 3 GLU A 184
HIS A 182
HIS A 181
 None
 0.90A 3co4A-5heiA:
undetectable		 3co4A-5heiA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 5hei NFRA2
(Bacillus
megaterium) 		5 / 12 LEU A  60
ILE A  78
CYH A  80
PHE A 155
LEU A 148
 None
 1.27A 3ko0A-5heiA:
undetectable
3ko0B-5heiA:
undetectable
3ko0C-5heiA:
undetectable
3ko0D-5heiA:
undetectable		 3ko0A-5heiA:
19.84
3ko0B-5heiA:
19.84
3ko0C-5heiA:
19.84
3ko0D-5heiA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 5hei NFRA2
(Bacillus
megaterium) 		5 / 12 LEU A  60
ILE A  78
CYH A  80
PHE A 155
LEU A 148
 None
 1.28A 3ko0G-5heiA:
undetectable
3ko0H-5heiA:
undetectable
3ko0I-5heiA:
undetectable
3ko0J-5heiA:
undetectable		 3ko0G-5heiA:
19.84
3ko0H-5heiA:
19.84
3ko0I-5heiA:
19.84
3ko0J-5heiA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 5hei NFRA2
(Bacillus
megaterium) 		5 / 11 LEU A 148
LEU A  60
ILE A  78
CYH A  80
PHE A 155
 None
 1.28A 3ko0A-5heiA:
undetectable
3ko0B-5heiA:
undetectable
3ko0I-5heiA:
undetectable
3ko0J-5heiA:
undetectable		 3ko0A-5heiA:
19.84
3ko0B-5heiA:
19.84
3ko0I-5heiA:
19.84
3ko0J-5heiA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5hei NFRA2
(Bacillus
megaterium) 		5 / 12 LEU A  60
GLY A 135
ILE A  78
ILE A 134
LEU A 150
 None
FMN  A 301 (-3.5A)
None
FMN  A 301 ( 4.1A)
None
 1.02A 3uj7B-5heiA:
undetectable		 3uj7B-5heiA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5hei NFRA2
(Bacillus
megaterium) 		4 / 4 LEU A  60
ALA A  64
ILE A 137
LYS A  56
 None
 1.26A 4eixA-5heiA:
undetectable		 4eixA-5heiA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5hei NFRA2
(Bacillus
megaterium) 		5 / 12 ALA A 120
ALA A 123
ALA A 124
VAL A  22
LEU A  75
 None
 1.05A 4j6dA-5heiA:
undetectable		 4j6dA-5heiA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5hei NFRA2
(Bacillus
megaterium) 		5 / 12 ALA A 120
ALA A 123
ALA A 124
VAL A  22
LEU A  75
 None
 1.04A 4j6dB-5heiA:
undetectable		 4j6dB-5heiA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5hei NFRA2
(Bacillus
megaterium) 		5 / 12 ALA A 120
ALA A 123
ALA A 124
VAL A  22
LEU A  75
 None
 1.05A 4jbtA-5heiA:
undetectable		 4jbtA-5heiA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5hei NFRA2
(Bacillus
megaterium) 		5 / 11 ALA A 120
ALA A 123
ALA A 124
VAL A  22
LEU A  75
 None
 1.05A 4jbtB-5heiA:
undetectable		 4jbtB-5heiA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5hei NFRA2
(Bacillus
megaterium) 		5 / 12 ILE A 115
GLY A 114
VAL A 157
SER A 116
ALA A  38
 None
 1.18A 5n0oA-5heiA:
undetectable		 5n0oA-5heiA:
22.06