SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hes'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1UWJ_A_BAXA1723_1 (B-RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	5 / 12	VAL A 30 ALA A 43 THR A 82 LEU A 121 HIS A 131	032 A 401 (-4.4A) 032 A 401 (-3.2A) 032 A 401 (-3.7A) None None	0.57A	1uwjA-5hesA: 10.3	1uwjA-5hesA: 31.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	6 / 12	ALA A 43 THR A 82 GLY A 88 ASP A 92 ASP A 151 PHE A 152	032 A 401 (-3.2A) 032 A 401 (-3.7A) 032 A 401 ( 4.0A) 032 A 401 (-4.3A) 032 A 401 (-4.6A) 032 A 401 (-4.1A)	0.75A	1xkkA-5hesA: 28.0	1xkkA-5hesA: 25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OGY_A_C2FA3000_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	5 / 12	PHE A 152 ILE A 72 LEU A 16 GLY A 70 GLN A 67	032 A 401 (-4.1A) None None None None	1.27A	2ogyA-5hesA: undetectable	2ogyA-5hesA: 20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OIQ_A_STIA1001_1 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	7 / 12	VAL A 30 ALA A 43 LYS A 45 ILE A 80 THR A 82 TYR A 84 GLY A 88	032 A 401 (-4.4A) 032 A 401 (-3.2A) 032 A 401 (-4.4A) 032 A 401 (-4.0A) 032 A 401 (-3.7A) 032 A 401 (-4.2A) 032 A 401 ( 4.0A)	0.52A	2oiqA-5hesA: 19.6	2oiqA-5hesA: 28.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CE6_A_ADNA500_2 (ADENOSYLHOMOCYSTEINA SE)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	4 / 5	GLN A 67 THR A 82 HIS A 131 LEU A 121	None 032 A 401 (-3.7A) None None	1.12A	3ce6A-5hesA: undetectable	3ce6A-5hesA: 21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CE6_C_ADNC500_2 (ADENOSYLHOMOCYSTEINA SE)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	4 / 5	GLN A 67 THR A 82 HIS A 131 LEU A 121	None 032 A 401 (-3.7A) None None	1.15A	3ce6C-5hesA: undetectable	3ce6C-5hesA: 21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CE6_D_ADND500_2 (ADENOSYLHOMOCYSTEINA SE)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	4 / 5	GLN A 67 THR A 82 HIS A 131 LEU A 121	None 032 A 401 (-3.7A) None None	1.14A	3ce6D-5hesA: undetectable	3ce6D-5hesA: 21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G0F_B_B49B9001_1 (MAST/STEM CELL GROWTH FACTOR RECEPTOR)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	6 / 10	VAL A 30 ALA A 43 THR A 82 TYR A 84 GLY A 88 CYH A 150	032 A 401 (-4.4A) 032 A 401 (-3.2A) 032 A 401 (-3.7A) 032 A 401 (-4.2A) 032 A 401 ( 4.0A) 032 A 401 (-3.6A)	0.78A	3g0fB-5hesA: 24.6	3g0fB-5hesA: 26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K8M_A_ACRA720_1 (ALPHA-AMYLASE, SUSG)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	4 / 7	TYR A 93 GLU A 100 LEU A 90 TRP A 110	None	1.24A	3k8mA-5hesA: undetectable	3k8mA-5hesA: 18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K8M_B_ACRB820_1 (ALPHA-AMYLASE, SUSG)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	4 / 7	TYR A 93 GLU A 100 LEU A 90 TRP A 110	None	1.29A	3k8mB-5hesA: undetectable	3k8mB-5hesA: 18.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	7 / 12	VAL A 30 ALA A 43 LYS A 45 LEU A 57 THR A 82 PHE A 152 GLY A 153	032 A 401 (-4.4A) 032 A 401 (-3.2A) 032 A 401 (-4.4A) 032 A 401 ( 4.7A) 032 A 401 (-3.7A) 032 A 401 (-4.1A) 032 A 401 (-3.6A)	0.60A	3og7A-5hesA: 26.8	3og7A-5hesA: 31.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OHT_B_1N1B1000_1 (P38A)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	6 / 12	VAL A 30 ALA A 43 LYS A 45 ILE A 66 THR A 82 GLY A 88	032 A 401 (-4.4A) 032 A 401 (-3.2A) 032 A 401 (-4.4A) 032 A 401 (-4.4A) 032 A 401 (-3.7A) 032 A 401 ( 4.0A)	0.88A	3ohtB-5hesA: 4.7	3ohtB-5hesA: 27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RGF_A_BAXA465_1 (CYCLIN-DEPENDENT KINASE 8)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	7 / 12	VAL A 30 ALA A 43 ILE A 66 TYR A 84 ALA A 85 LEU A 121 HIS A 131	032 A 401 (-4.4A) 032 A 401 (-3.2A) 032 A 401 (-4.4A) 032 A 401 (-4.2A) 032 A 401 (-3.6A) None None	0.94A	3rgfA-5hesA: 20.9	3rgfA-5hesA: 25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3THR_A_C2FA1100_1 (GLYCINE N-METHYLTRANSFERASE)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	3 / 3	LEU A 121 HIS A 122 MET A 118	None	0.96A	3thrD-5hesA: undetectable	3thrD-5hesA: 25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AN2_A_EUIA1382_1 (DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	6 / 12	LYS A 45 LEU A 57 ASP A 133 LYS A 135 ASN A 138 ASP A 151	032 A 401 (-4.4A) 032 A 401 ( 4.7A) None None None 032 A 401 (-4.6A)	0.97A	4an2A-5hesA: 24.8	4an2A-5hesA: 24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AN2_A_EUIA1382_1 (DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	6 / 12	LYS A 45 LEU A 57 ASP A 133 LYS A 135 ASN A 138 ASP A 151	032 A 401 (-4.4A) 032 A 401 ( 4.7A) None None None 032 A 401 (-4.6A)	1.34A	4an2A-5hesA: 24.8	4an2A-5hesA: 24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AN2_A_EUIA1382_1 (DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	6 / 12	LYS A 45 LEU A 57 ILE A 80 ASP A 133 LYS A 135 ASN A 138	032 A 401 (-4.4A) 032 A 401 ( 4.7A) 032 A 401 (-4.0A) None None None	0.89A	4an2A-5hesA: 24.8	4an2A-5hesA: 24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AN2_A_EUIA1382_1 (DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	6 / 12	LYS A 45 LEU A 57 ILE A 80 ASP A 133 LYS A 135 ASN A 138	032 A 401 (-4.4A) 032 A 401 ( 4.7A) 032 A 401 (-4.0A) None None None	1.35A	4an2A-5hesA: 24.8	4an2A-5hesA: 24.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4C8B_A_0LIA1000_2 (RECEPTOR-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 2)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	4 / 5	VAL A 30 ILE A 65 TYR A 84 ILE A 149	032 A 401 (-4.4A) None 032 A 401 (-4.2A) None	0.61A	4c8bA-5hesA: 26.1	4c8bA-5hesA: 31.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CX7_B_H4BB600_1 (NITRIC OXIDE SYNTHASE, INDUCIBLE)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	4 / 8	PHE A 253 HIS A 122 GLU A 124 ILE A 257	None	1.24A	4cx7A-5hesA: undetectable 4cx7B-5hesA: undetectable	4cx7A-5hesA: 21.99 4cx7B-5hesA: 21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G19_D_ACTD302_0 (GLUTATHIONE TRANSFERASE GTE1)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	3 / 3	TYR A 190 PHE A 206 ARG A 224	None	1.23A	4g19D-5hesA: undetectable	4g19D-5hesA: 23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4I41_A_MIXA500_1 (SERINE/THREONINE-PRO TEIN KINASE PIM-1)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	7 / 12	VAL A 30 ALA A 43 ILE A 66 ASP A 92 ASP A 133 ASN A 138 ASP A 151	032 A 401 (-4.4A) 032 A 401 (-3.2A) 032 A 401 (-4.4A) 032 A 401 (-4.3A) None None 032 A 401 (-4.6A)	0.71A	4i41A-5hesA: 20.6	4i41A-5hesA: 23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MXO_A_DB8A601_1 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	8 / 12	VAL A 30 ALA A 43 LYS A 45 ILE A 80 THR A 82 TYR A 84 GLY A 88 ASP A 151	032 A 401 (-4.4A) 032 A 401 (-3.2A) 032 A 401 (-4.4A) 032 A 401 (-4.0A) 032 A 401 (-3.7A) 032 A 401 (-4.2A) 032 A 401 ( 4.0A) 032 A 401 (-4.6A)	0.80A	4mxoA-5hesA: 27.2	4mxoA-5hesA: 28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R20_A_AERA602_1 (CYTOCHROME P450 FAMILY 17 POLYPEPTIDE 2)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	4 / 8	GLU A 53 GLY A 153 VAL A 30 SER A 29	None 032 A 401 (-3.6A) 032 A 401 (-4.4A) None	0.82A	4r20A-5hesA: undetectable	4r20A-5hesA: 20.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	6 / 12	ALA A 43 ILE A 80 THR A 82 SER A 86 PHE A 152 GLY A 153	032 A 401 (-3.2A) 032 A 401 (-4.0A) 032 A 401 (-3.7A) None 032 A 401 (-4.1A) 032 A 401 (-3.6A)	1.46A	4rzvA-5hesA: 27.9	4rzvA-5hesA: 32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	7 / 12	ALA A 43 LYS A 45 ILE A 80 THR A 82 SER A 89 PHE A 152 GLY A 153	032 A 401 (-3.2A) 032 A 401 (-4.4A) 032 A 401 (-4.0A) 032 A 401 (-3.7A) None 032 A 401 (-4.1A) 032 A 401 (-3.6A)	0.58A	4rzvA-5hesA: 27.9	4rzvA-5hesA: 32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	7 / 12	VAL A 30 ALA A 43 LYS A 45 THR A 82 SER A 89 PHE A 152 GLY A 153	032 A 401 (-4.4A) 032 A 401 (-3.2A) 032 A 401 (-4.4A) 032 A 401 (-3.7A) None 032 A 401 (-4.1A) 032 A 401 (-3.6A)	0.63A	4rzvB-5hesA: 21.6	4rzvB-5hesA: 32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4TYJ_A_0LIA801_2 (FIBROBLAST GROWTH FACTOR RECEPTOR 4)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	4 / 6	VAL A 30 LYS A 45 ILE A 65 ILE A 149	032 A 401 (-4.4A) 032 A 401 (-4.4A) None None	0.68A	4tyjA-5hesA: 7.1	4tyjA-5hesA: 30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UXQ_A_0LIA1752_2 (FIBROBLAST GROWTH FACTOR RECEPTOR 4)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	4 / 7	VAL A 30 ALA A 85 ARG A 132 ILE A 149	032 A 401 (-4.4A) 032 A 401 (-3.6A) None None	0.69A	4uxqA-5hesA: 25.6	4uxqA-5hesA: 30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UXQ_A_0LIA1752_2 (FIBROBLAST GROWTH FACTOR RECEPTOR 4)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	4 / 7	VAL A 30 ILE A 66 ALA A 85 ILE A 149	032 A 401 (-4.4A) 032 A 401 (-4.4A) 032 A 401 (-3.6A) None	0.70A	4uxqA-5hesA: 25.6	4uxqA-5hesA: 30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UXQ_A_0LIA1752_2 (FIBROBLAST GROWTH FACTOR RECEPTOR 4)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	5 / 7	VAL A 30 LYS A 45 ILE A 66 ALA A 85 ILE A 65	032 A 401 (-4.4A) 032 A 401 (-4.4A) 032 A 401 (-4.4A) 032 A 401 (-3.6A) None	1.22A	4uxqA-5hesA: 25.6	4uxqA-5hesA: 30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4V04_A_0LIA1772_1 (FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	6 / 12	VAL A 30 ALA A 43 ALA A 85 LEU A 121 HIS A 131 GLY A 153	032 A 401 (-4.4A) 032 A 401 (-3.2A) 032 A 401 (-3.6A) None None 032 A 401 (-3.6A)	0.68A	4v04A-5hesA: 25.7	4v04A-5hesA: 30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4V04_A_0LIA1772_2 (FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	4 / 8	ILE A 66 TYR A 84 ARG A 132 ILE A 149	032 A 401 (-4.4A) 032 A 401 (-4.2A) None None	0.80A	4v04A-5hesA: 25.7	4v04A-5hesA: 30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4V04_A_0LIA1772_2 (FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	4 / 8	LYS A 45 ILE A 66 ARG A 132 ILE A 149	032 A 401 (-4.4A) 032 A 401 (-4.4A) None None	0.76A	4v04A-5hesA: 25.7	4v04A-5hesA: 30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4V04_B_0LIB1771_1 (FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	6 / 10	VAL A 30 LYS A 45 ILE A 66 TYR A 84 ARG A 132 ILE A 149	032 A 401 (-4.4A) 032 A 401 (-4.4A) 032 A 401 (-4.4A) 032 A 401 (-4.2A) None None	0.72A	4v04B-5hesA: 20.4	4v04B-5hesA: 30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4V04_B_0LIB1771_2 (FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	5 / 12	ALA A 43 ALA A 85 LEU A 121 HIS A 131 GLY A 153	032 A 401 (-3.2A) 032 A 401 (-3.6A) None None 032 A 401 (-3.6A)	0.50A	4v04B-5hesA: 20.4	4v04B-5hesA: 30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4V04_B_0LIB1771_2 (FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	5 / 12	ALA A 85 LEU A 121 HIS A 131 ASP A 151 GLY A 153	032 A 401 (-3.6A) None None 032 A 401 (-4.6A) 032 A 401 (-3.6A)	0.95A	4v04B-5hesA: 20.4	4v04B-5hesA: 30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4XV2_A_P06A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	5 / 12	VAL A 30 ALA A 43 LYS A 45 THR A 82 ASP A 151	032 A 401 (-4.4A) 032 A 401 (-3.2A) 032 A 401 (-4.4A) 032 A 401 (-3.7A) 032 A 401 (-4.6A)	0.62A	4xv2A-5hesA: 26.7	4xv2A-5hesA: 31.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4XV2_B_P06B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	5 / 12	ALA A 43 LYS A 45 LEU A 57 THR A 82 ASP A 151	032 A 401 (-3.2A) 032 A 401 (-4.4A) 032 A 401 ( 4.7A) 032 A 401 (-3.7A) 032 A 401 (-4.6A)	0.64A	4xv2B-5hesA: 7.5	4xv2B-5hesA: 31.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5CSW_A_P06A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	5 / 12	VAL A 30 ALA A 43 LYS A 45 LEU A 57 THR A 82	032 A 401 (-4.4A) 032 A 401 (-3.2A) 032 A 401 (-4.4A) 032 A 401 ( 4.7A) 032 A 401 (-3.7A)	0.67A	5cswA-5hesA: 26.4	5cswA-5hesA: 32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5CSW_B_P06B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	5 / 12	VAL A 30 ALA A 43 LYS A 45 LEU A 57 THR A 82	032 A 401 (-4.4A) 032 A 401 (-3.2A) 032 A 401 (-4.4A) 032 A 401 ( 4.7A) 032 A 401 (-3.7A)	0.67A	5cswB-5hesA: 26.3	5cswB-5hesA: 32.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F1A_A_SALA601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	4 / 8	LEU A 47 LEU A 57 GLY A 153 ALA A 154	None 032 A 401 ( 4.7A) 032 A 401 (-3.6A) None	0.78A	5f1aA-5hesA: undetectable	5f1aA-5hesA: 20.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HIE_A_P06A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	6 / 12	VAL A 30 ALA A 43 LYS A 45 LEU A 57 ILE A 80 THR A 82	032 A 401 (-4.4A) 032 A 401 (-3.2A) 032 A 401 (-4.4A) 032 A 401 ( 4.7A) 032 A 401 (-4.0A) 032 A 401 (-3.7A)	0.70A	5hieA-5hesA: 26.4	5hieA-5hesA: 31.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HIE_B_P06B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	5 / 12	VAL A 30 ALA A 43 LYS A 45 ILE A 80 THR A 82	032 A 401 (-4.4A) 032 A 401 (-3.2A) 032 A 401 (-4.4A) 032 A 401 (-4.0A) 032 A 401 (-3.7A)	0.56A	5hieB-5hesA: 26.3	5hieB-5hesA: 31.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HIE_C_P06C801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	6 / 12	GLY A 28 VAL A 30 ALA A 43 LYS A 45 THR A 82 ASP A 151	None 032 A 401 (-4.4A) 032 A 401 (-3.2A) 032 A 401 (-4.4A) 032 A 401 (-3.7A) 032 A 401 (-4.6A)	0.91A	5hieC-5hesA: 20.6	5hieC-5hesA: 31.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HIE_D_P06D801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	5 / 12	VAL A 30 ALA A 43 LYS A 45 ILE A 80 THR A 82	032 A 401 (-4.4A) 032 A 401 (-3.2A) 032 A 401 (-4.4A) 032 A 401 (-4.0A) 032 A 401 (-3.7A)	0.55A	5hieD-5hesA: 26.3	5hieD-5hesA: 31.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5I9X_A_DB8A1001_1 (EPHRIN TYPE-A RECEPTOR 2)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	7 / 12	ALA A 43 LYS A 45 ILE A 66 ILE A 80 THR A 82 TYR A 84 GLY A 88	032 A 401 (-3.2A) 032 A 401 (-4.4A) 032 A 401 (-4.4A) 032 A 401 (-4.0A) 032 A 401 (-3.7A) 032 A 401 (-4.2A) 032 A 401 ( 4.0A)	0.60A	5i9xA-5hesA: 27.2	5i9xA-5hesA: 30.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5P9I_A_1E8A701_1 (TYROSINE-PROTEIN KINASE BTK)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	6 / 12	VAL A 30 ALA A 43 LYS A 45 ILE A 80 THR A 82 PHE A 152	032 A 401 (-4.4A) 032 A 401 (-3.2A) 032 A 401 (-4.4A) 032 A 401 (-4.0A) 032 A 401 (-3.7A) 032 A 401 (-4.1A)	0.85A	5p9iA-5hesA: 22.0	5p9iA-5hesA: 28.32

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1UWJ_A_BAXA1723_1","B-RAF PROTO-ONCOGENE SERINE\/THREONINE-PROTEIN KINASE","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",5,"VAL A  30;ALA A  43;THR A  82;LEU A 121;HIS A 131","032 A 401 (-4.4A);032 A 401 (-3.2A);032 A 401 (-3.7A);None;None","0.57A","1uwjA-5hesA:10.3","1uwjA-5hesA:31.55"],["1XKK_A_FMMA91_1","EPIDERMAL GROWTH FACTOR RECEPTOR","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",6,"ALA A  43;THR A  82;GLY A  88;ASP A  92;ASP A 151;PHE A 152","032 A 401 (-3.2A);032 A 401 (-3.7A);032 A 401 ( 4.0A);032 A 401 (-4.3A);032 A 401 (-4.6A);032 A 401 (-4.1A)","0.75A","1xkkA-5hesA:28.0","1xkkA-5hesA:25.90"],["2OGY_A_C2FA3000_0","5-METHYLTETRAHYDROFOLATE CORRINOID\/IRON SULFUR PROTEIN METHYLTRANSFERASE","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",5,"PHE A 152;ILE A  72;LEU A  16;GLY A  70;GLN A  67","032 A 401 (-4.1A);None;None;None;None","1.27A","2ogyA-5hesA:undetectable","2ogyA-5hesA:20.97"],["2OIQ_A_STIA1001_1","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",7,"VAL A  30;ALA A  43;LYS A  45;ILE A  80;THR A  82;TYR A  84;GLY A  88","032 A 401 (-4.4A);032 A 401 (-3.2A);032 A 401 (-4.4A);032 A 401 (-4.0A);032 A 401 (-3.7A);032 A 401 (-4.2A);032 A 401 ( 4.0A)","0.52A","2oiqA-5hesA:19.6","2oiqA-5hesA:28.79"],["3CE6_A_ADNA500_2","ADENOSYLHOMOCYSTEINASE","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",4,"GLN A  67;THR A  82;HIS A 131;LEU A 121","None;032 A 401 (-3.7A);None;None","1.12A","3ce6A-5hesA:undetectable","3ce6A-5hesA:21.75"],["3CE6_C_ADNC500_2","ADENOSYLHOMOCYSTEINASE","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",4,"GLN A  67;THR A  82;HIS A 131;LEU A 121","None;032 A 401 (-3.7A);None;None","1.15A","3ce6C-5hesA:undetectable","3ce6C-5hesA:21.75"],["3CE6_D_ADND500_2","ADENOSYLHOMOCYSTEINASE","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",4,"GLN A  67;THR A  82;HIS A 131;LEU A 121","None;032 A 401 (-3.7A);None;None","1.14A","3ce6D-5hesA:undetectable","3ce6D-5hesA:21.75"],["3G0F_B_B49B9001_1","MAST\/STEM CELL GROWTH FACTOR RECEPTOR","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",6,"VAL A  30;ALA A  43;THR A  82;TYR A  84;GLY A  88;CYH A 150","032 A 401 (-4.4A);032 A 401 (-3.2A);032 A 401 (-3.7A);032 A 401 (-4.2A);032 A 401 ( 4.0A);032 A 401 (-3.6A)","0.78A","3g0fB-5hesA:24.6","3g0fB-5hesA:26.79"],["3K8M_A_ACRA720_1","ALPHA-AMYLASE, SUSG","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",4,"TYR A  93;GLU A 100;LEU A  90;TRP A 110","None","1.24A","3k8mA-5hesA:undetectable","3k8mA-5hesA:18.76"],["3K8M_B_ACRB820_1","ALPHA-AMYLASE, SUSG","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",4,"TYR A  93;GLU A 100;LEU A  90;TRP A 110","None","1.29A","3k8mB-5hesA:undetectable","3k8mB-5hesA:18.76"],["3OG7_A_032A1_1","AKAP9-BRAF FUSION PROTEIN","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",7,"VAL A  30;ALA A  43;LYS A  45;LEU A  57;THR A  82;PHE A 152;GLY A 153","032 A 401 (-4.4A);032 A 401 (-3.2A);032 A 401 (-4.4A);032 A 401 ( 4.7A);032 A 401 (-3.7A);032 A 401 (-4.1A);032 A 401 (-3.6A)","0.60A","3og7A-5hesA:26.8","3og7A-5hesA:31.01"],["3OHT_B_1N1B1000_1","P38A","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",6,"VAL A  30;ALA A  43;LYS A  45;ILE A  66;THR A  82;GLY A  88","032 A 401 (-4.4A);032 A 401 (-3.2A);032 A 401 (-4.4A);032 A 401 (-4.4A);032 A 401 (-3.7A);032 A 401 ( 4.0A)","0.88A","3ohtB-5hesA:4.7","3ohtB-5hesA:27.55"],["3RGF_A_BAXA465_1","CYCLIN-DEPENDENT KINASE 8","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",7,"VAL A  30;ALA A  43;ILE A  66;TYR A  84;ALA A  85;LEU A 121;HIS A 131","032 A 401 (-4.4A);032 A 401 (-3.2A);032 A 401 (-4.4A);032 A 401 (-4.2A);032 A 401 (-3.6A);None;None","0.94A","3rgfA-5hesA:20.9","3rgfA-5hesA:25.89"],["3THR_A_C2FA1100_1","GLYCINE N-METHYLTRANSFERASE","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",3,"LEU A 121;HIS A 122;MET A 118","None","0.96A","3thrD-5hesA:undetectable","3thrD-5hesA:25.28"],["4AN2_A_EUIA1382_1","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",6,"LYS A  45;LEU A  57;ASP A 133;LYS A 135;ASN A 138;ASP A 151","032 A 401 (-4.4A);032 A 401 ( 4.7A);None;None;None;032 A 401 (-4.6A)","0.97A","4an2A-5hesA:24.8","4an2A-5hesA:24.61"],["4AN2_A_EUIA1382_1","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",6,"LYS A  45;LEU A  57;ASP A 133;LYS A 135;ASN A 138;ASP A 151","032 A 401 (-4.4A);032 A 401 ( 4.7A);None;None;None;032 A 401 (-4.6A)","1.34A","4an2A-5hesA:24.8","4an2A-5hesA:24.61"],["4AN2_A_EUIA1382_1","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",6,"LYS A  45;LEU A  57;ILE A  80;ASP A 133;LYS A 135;ASN A 138","032 A 401 (-4.4A);032 A 401 ( 4.7A);032 A 401 (-4.0A);None;None;None","0.89A","4an2A-5hesA:24.8","4an2A-5hesA:24.61"],["4AN2_A_EUIA1382_1","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",6,"LYS A  45;LEU A  57;ILE A  80;ASP A 133;LYS A 135;ASN A 138","032 A 401 (-4.4A);032 A 401 ( 4.7A);032 A 401 (-4.0A);None;None;None","1.35A","4an2A-5hesA:24.8","4an2A-5hesA:24.61"],["4C8B_A_0LIA1000_2","RECEPTOR-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 2","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",4,"VAL A  30;ILE A  65;TYR A  84;ILE A 149","032 A 401 (-4.4A);None;032 A 401 (-4.2A);None","0.61A","4c8bA-5hesA:26.1","4c8bA-5hesA:31.05"],["4CX7_B_H4BB600_1","NITRIC OXIDE SYNTHASE, INDUCIBLE;NITRIC OXIDE SYNTHASE, INDUCIBLE","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",4,"PHE A 253;HIS A 122;GLU A 124;ILE A 257","None","1.24A","4cx7A-5hesA:undetectable;4cx7B-5hesA:undetectable","4cx7A-5hesA:21.99;4cx7B-5hesA:21.99"],["4G19_D_ACTD302_0","GLUTATHIONE TRANSFERASE GTE1","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",3,"TYR A 190;PHE A 206;ARG A 224","None","1.23A","4g19D-5hesA:undetectable","4g19D-5hesA:23.69"],["4I41_A_MIXA500_1","SERINE\/THREONINE-PROTEIN KINASE PIM-1","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",7,"VAL A  30;ALA A  43;ILE A  66;ASP A  92;ASP A 133;ASN A 138;ASP A 151","032 A 401 (-4.4A);032 A 401 (-3.2A);032 A 401 (-4.4A);032 A 401 (-4.3A);None;None;032 A 401 (-4.6A)","0.71A","4i41A-5hesA:20.6","4i41A-5hesA:23.58"],["4MXO_A_DB8A601_1","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",8,"VAL A  30;ALA A  43;LYS A  45;ILE A  80;THR A  82;TYR A  84;GLY A  88;ASP A 151","032 A 401 (-4.4A);032 A 401 (-3.2A);032 A 401 (-4.4A);032 A 401 (-4.0A);032 A 401 (-3.7A);032 A 401 (-4.2A);032 A 401 ( 4.0A);032 A 401 (-4.6A)","0.80A","4mxoA-5hesA:27.2","4mxoA-5hesA:28.48"],["4R20_A_AERA602_1","CYTOCHROME P450 FAMILY 17 POLYPEPTIDE 2","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",4,"GLU A  53;GLY A 153;VAL A  30;SER A  29","None;032 A 401 (-3.6A);032 A 401 (-4.4A);None","0.82A","4r20A-5hesA:undetectable","4r20A-5hesA:20.04"],["4RZV_A_032A801_1","SERINE\/THREONINE-PROTEIN KINASE B-RAF","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",6,"ALA A  43;ILE A  80;THR A  82;SER A  86;PHE A 152;GLY A 153","032 A 401 (-3.2A);032 A 401 (-4.0A);032 A 401 (-3.7A);None;032 A 401 (-4.1A);032 A 401 (-3.6A)","1.46A","4rzvA-5hesA:27.9","4rzvA-5hesA:32.23"],["4RZV_A_032A801_1","SERINE\/THREONINE-PROTEIN KINASE B-RAF","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",7,"ALA A  43;LYS A  45;ILE A  80;THR A  82;SER A  89;PHE A 152;GLY A 153","032 A 401 (-3.2A);032 A 401 (-4.4A);032 A 401 (-4.0A);032 A 401 (-3.7A);None;032 A 401 (-4.1A);032 A 401 (-3.6A)","0.58A","4rzvA-5hesA:27.9","4rzvA-5hesA:32.23"],["4RZV_B_032B801_1","SERINE\/THREONINE-PROTEIN KINASE B-RAF","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",7,"VAL A  30;ALA A  43;LYS A  45;THR A  82;SER A  89;PHE A 152;GLY A 153","032 A 401 (-4.4A);032 A 401 (-3.2A);032 A 401 (-4.4A);032 A 401 (-3.7A);None;032 A 401 (-4.1A);032 A 401 (-3.6A)","0.63A","4rzvB-5hesA:21.6","4rzvB-5hesA:32.23"],["4TYJ_A_0LIA801_2","FIBROBLAST GROWTH FACTOR RECEPTOR 4","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",4,"VAL A  30;LYS A  45;ILE A  65;ILE A 149","032 A 401 (-4.4A);032 A 401 (-4.4A);None;None","0.68A","4tyjA-5hesA:7.1","4tyjA-5hesA:30.79"],["4UXQ_A_0LIA1752_2","FIBROBLAST GROWTH FACTOR RECEPTOR 4","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",4,"VAL A  30;ALA A  85;ARG A 132;ILE A 149","032 A 401 (-4.4A);032 A 401 (-3.6A);None;None","0.69A","4uxqA-5hesA:25.6","4uxqA-5hesA:30.48"],["4UXQ_A_0LIA1752_2","FIBROBLAST GROWTH FACTOR RECEPTOR 4","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",4,"VAL A  30;ILE A  66;ALA A  85;ILE A 149","032 A 401 (-4.4A);032 A 401 (-4.4A);032 A 401 (-3.6A);None","0.70A","4uxqA-5hesA:25.6","4uxqA-5hesA:30.48"],["4UXQ_A_0LIA1752_2","FIBROBLAST GROWTH FACTOR RECEPTOR 4","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",5,"VAL A  30;LYS A  45;ILE A  66;ALA A  85;ILE A  65","032 A 401 (-4.4A);032 A 401 (-4.4A);032 A 401 (-4.4A);032 A 401 (-3.6A);None","1.22A","4uxqA-5hesA:25.6","4uxqA-5hesA:30.48"],["4V04_A_0LIA1772_1","FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",6,"VAL A  30;ALA A  43;ALA A  85;LEU A 121;HIS A 131;GLY A 153","032 A 401 (-4.4A);032 A 401 (-3.2A);032 A 401 (-3.6A);None;None;032 A 401 (-3.6A)","0.68A","4v04A-5hesA:25.7","4v04A-5hesA:30.59"],["4V04_A_0LIA1772_2","FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",4,"ILE A  66;TYR A  84;ARG A 132;ILE A 149","032 A 401 (-4.4A);032 A 401 (-4.2A);None;None","0.80A","4v04A-5hesA:25.7","4v04A-5hesA:30.59"],["4V04_A_0LIA1772_2","FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",4,"LYS A  45;ILE A  66;ARG A 132;ILE A 149","032 A 401 (-4.4A);032 A 401 (-4.4A);None;None","0.76A","4v04A-5hesA:25.7","4v04A-5hesA:30.59"],["4V04_B_0LIB1771_1","FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",6,"VAL A  30;LYS A  45;ILE A  66;TYR A  84;ARG A 132;ILE A 149","032 A 401 (-4.4A);032 A 401 (-4.4A);032 A 401 (-4.4A);032 A 401 (-4.2A);None;None","0.72A","4v04B-5hesA:20.4","4v04B-5hesA:30.59"],["4V04_B_0LIB1771_2","FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",5,"ALA A  43;ALA A  85;LEU A 121;HIS A 131;GLY A 153","032 A 401 (-3.2A);032 A 401 (-3.6A);None;None;032 A 401 (-3.6A)","0.50A","4v04B-5hesA:20.4","4v04B-5hesA:30.59"],["4V04_B_0LIB1771_2","FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",5,"ALA A  85;LEU A 121;HIS A 131;ASP A 151;GLY A 153","032 A 401 (-3.6A);None;None;032 A 401 (-4.6A);032 A 401 (-3.6A)","0.95A","4v04B-5hesA:20.4","4v04B-5hesA:30.59"],["4XV2_A_P06A801_1","SERINE\/THREONINE-PROTEIN KINASE B-RAF","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",5,"VAL A  30;ALA A  43;LYS A  45;THR A  82;ASP A 151","032 A 401 (-4.4A);032 A 401 (-3.2A);032 A 401 (-4.4A);032 A 401 (-3.7A);032 A 401 (-4.6A)","0.62A","4xv2A-5hesA:26.7","4xv2A-5hesA:31.49"],["4XV2_B_P06B801_1","SERINE\/THREONINE-PROTEIN KINASE B-RAF","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",5,"ALA A  43;LYS A  45;LEU A  57;THR A  82;ASP A 151","032 A 401 (-3.2A);032 A 401 (-4.4A);032 A 401 ( 4.7A);032 A 401 (-3.7A);032 A 401 (-4.6A)","0.64A","4xv2B-5hesA:7.5","4xv2B-5hesA:31.49"],["5CSW_A_P06A801_1","SERINE\/THREONINE-PROTEIN KINASE B-RAF","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",5,"VAL A  30;ALA A  43;LYS A  45;LEU A  57;THR A  82","032 A 401 (-4.4A);032 A 401 (-3.2A);032 A 401 (-4.4A);032 A 401 ( 4.7A);032 A 401 (-3.7A)","0.67A","5cswA-5hesA:26.4","5cswA-5hesA:32.43"],["5CSW_B_P06B801_1","SERINE\/THREONINE-PROTEIN KINASE B-RAF","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",5,"VAL A  30;ALA A  43;LYS A  45;LEU A  57;THR A  82","032 A 401 (-4.4A);032 A 401 (-3.2A);032 A 401 (-4.4A);032 A 401 ( 4.7A);032 A 401 (-3.7A)","0.67A","5cswB-5hesA:26.3","5cswB-5hesA:32.43"],["5F1A_A_SALA601_1","PROSTAGLANDIN G\/H SYNTHASE 2","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",4,"LEU A  47;LEU A  57;GLY A 153;ALA A 154","None;032 A 401 ( 4.7A);032 A 401 (-3.6A);None","0.78A","5f1aA-5hesA:undetectable","5f1aA-5hesA:20.48"],["5HIE_A_P06A801_1","SERINE\/THREONINE-PROTEIN KINASE B-RAF","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",6,"VAL A  30;ALA A  43;LYS A  45;LEU A  57;ILE A  80;THR A  82","032 A 401 (-4.4A);032 A 401 (-3.2A);032 A 401 (-4.4A);032 A 401 ( 4.7A);032 A 401 (-4.0A);032 A 401 (-3.7A)","0.70A","5hieA-5hesA:26.4","5hieA-5hesA:31.59"],["5HIE_B_P06B801_1","SERINE\/THREONINE-PROTEIN KINASE B-RAF","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",5,"VAL A  30;ALA A  43;LYS A  45;ILE A  80;THR A  82","032 A 401 (-4.4A);032 A 401 (-3.2A);032 A 401 (-4.4A);032 A 401 (-4.0A);032 A 401 (-3.7A)","0.56A","5hieB-5hesA:26.3","5hieB-5hesA:31.59"],["5HIE_C_P06C801_1","SERINE\/THREONINE-PROTEIN KINASE B-RAF","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",6,"GLY A  28;VAL A  30;ALA A  43;LYS A  45;THR A  82;ASP A 151","None;032 A 401 (-4.4A);032 A 401 (-3.2A);032 A 401 (-4.4A);032 A 401 (-3.7A);032 A 401 (-4.6A)","0.91A","5hieC-5hesA:20.6","5hieC-5hesA:31.59"],["5HIE_D_P06D801_1","SERINE\/THREONINE-PROTEIN KINASE B-RAF","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",5,"VAL A  30;ALA A  43;LYS A  45;ILE A  80;THR A  82","032 A 401 (-4.4A);032 A 401 (-3.2A);032 A 401 (-4.4A);032 A 401 (-4.0A);032 A 401 (-3.7A)","0.55A","5hieD-5hesA:26.3","5hieD-5hesA:31.59"],["5I9X_A_DB8A1001_1","EPHRIN TYPE-A RECEPTOR 2","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",7,"ALA A  43;LYS A  45;ILE A  66;ILE A  80;THR A  82;TYR A  84;GLY A  88","032 A 401 (-3.2A);032 A 401 (-4.4A);032 A 401 (-4.4A);032 A 401 (-4.0A);032 A 401 (-3.7A);032 A 401 (-4.2A);032 A 401 ( 4.0A)","0.60A","5i9xA-5hesA:27.2","5i9xA-5hesA:30.15"],["5P9I_A_1E8A701_1","TYROSINE-PROTEIN KINASE BTK","5hes","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT","Homo sapiens",6,"VAL A  30;ALA A  43;LYS A  45;ILE A  80;THR A  82;PHE A 152","032 A 401 (-4.4A);032 A 401 (-3.2A);032 A 401 (-4.4A);032 A 401 (-4.0A);032 A 401 (-3.7A);032 A 401 (-4.1A)","0.85A","5p9iA-5hesA:22.0","5p9iA-5hesA:28.32"]]