SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hf4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5hf4 DISKS LARGE HOMOLOG
4
(Rattus
norvegicus) 		6 / 10 ALA A 375
ALA A 378
GLN A 374
ASN A 363
ALA A 370
ILE A 314
 None
 1.47A 2aclC-5hf4A:
undetectable		 2aclC-5hf4A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5hf4 DISKS LARGE HOMOLOG
4
(Rattus
norvegicus) 		4 / 5 GLN A 358
PHE A 337
PHE A 400
GLY A 333
 None
 1.23A 2qmzA-5hf4A:
undetectable
2qmzB-5hf4A:
undetectable		 2qmzA-5hf4A:
21.83
2qmzB-5hf4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5hf4 DISKS LARGE HOMOLOG
4
(Rattus
norvegicus) 		5 / 12 ILE A 412
PHE A 337
VAL A 328
SER A 398
ILE A 307
 None
 0.99A 5n0sB-5hf4A:
undetectable		 5n0sB-5hf4A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5hf4 DISKS LARGE HOMOLOG
4
(Rattus
norvegicus) 		5 / 11 GLY A 330
GLY A 333
SER A 361
GLU A 373
ALA A 375
 None
 1.03A 5o96G-5hf4A:
undetectable		 5o96G-5hf4A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 5hf4 DISKS LARGE HOMOLOG
4
(Rattus
norvegicus) 		5 / 12 ALA A 370
ARG A 368
GLY A 335
GLY A 329
LEU A 353
 None
 1.07A 5ul4A-5hf4A:
undetectable		 5ul4A-5hf4A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 5hf4 DISKS LARGE HOMOLOG
4
(Rattus
norvegicus) 		5 / 12 GLN A 374
ALA A 370
GLY A 330
GLU A 331
PHE A 400
 None
 1.27A 5vlmF-5hf4A:
undetectable		 5vlmF-5hf4A:
22.29