SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hfi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1BZF_A_TMQA170_1 (DIHYDROFOLATE REDUCTASE)	5hfi	UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM (Pseudomonas aeruginosa)	5 / 12	ALA A 27 HIS A 7 LEU A 6 LEU A 191 ALA A 20	ALA A 27 ( 0.0A) HIS A 7 ( 1.0A) LEU A 6 ( 0.6A) LEU A 191 ( 0.6A) ALA A 20 ( 0.0A)	1.09A	1bzfA-5hfiA: undetectable	1bzfA-5hfiA: 23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1K74_A_9CRA463_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5hfi	UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM (Pseudomonas aeruginosa)	5 / 12	ALA A 149 ALA A 147 LEU A 134 LEU A 105 ALA A 101	ALA A 149 ( 0.0A) ALA A 147 ( 0.0A) LEU A 134 ( 0.6A) LEU A 105 ( 0.6A) ALA A 101 ( 0.0A)	0.92A	1k74A-5hfiA: undetectable	1k74A-5hfiA: 20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P33_A_MTXA351_1 (PTERIDINE REDUCTASE 1)	5hfi	UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM (Pseudomonas aeruginosa)	5 / 12	PHE A 206 LEU A 191 TYR A 196 LEU A 33 LEU A 211	PHE A 206 ( 1.3A) LEU A 191 ( 0.6A) TYR A 196 ( 1.3A) LEU A 33 ( 0.6A) LEU A 211 ( 0.6A)	1.34A	1p33A-5hfiA: undetectable	1p33A-5hfiA: 22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P33_B_MTXB352_1 (PTERIDINE REDUCTASE 1)	5hfi	UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM (Pseudomonas aeruginosa)	5 / 12	PHE A 206 LEU A 191 TYR A 196 LEU A 33 LEU A 211	PHE A 206 ( 1.3A) LEU A 191 ( 0.6A) TYR A 196 ( 1.3A) LEU A 33 ( 0.6A) LEU A 211 ( 0.6A)	1.33A	1p33B-5hfiA: undetectable	1p33B-5hfiA: 22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P33_C_MTXC353_1 (PTERIDINE REDUCTASE 1)	5hfi	UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM (Pseudomonas aeruginosa)	5 / 12	PHE A 206 LEU A 191 TYR A 196 LEU A 33 LEU A 211	PHE A 206 ( 1.3A) LEU A 191 ( 0.6A) TYR A 196 ( 1.3A) LEU A 33 ( 0.6A) LEU A 211 ( 0.6A)	1.29A	1p33C-5hfiA: undetectable	1p33C-5hfiA: 22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UW6_A_NCTA1208_1 (ACETYLCHOLINE-BINDIN G PROTEIN)	5hfi	UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM (Pseudomonas aeruginosa)	4 / 8	TYR A 196 THR A 209 TRP A 203 LEU A 4	TYR A 196 ( 1.3A) THR A 209 ( 0.8A) TRP A 203 ( 0.5A) LEU A 4 ( 0.6A)	1.42A	1uw6A-5hfiA: undetectable 1uw6B-5hfiA: undetectable	1uw6A-5hfiA: 18.70 1uw6B-5hfiA: 18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UW6_T_NCTT1208_1 (ACETYLCHOLINE-BINDIN G PROTEIN)	5hfi	UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM (Pseudomonas aeruginosa)	4 / 8	TRP A 203 LEU A 4 TYR A 196 THR A 209	TRP A 203 ( 0.5A) LEU A 4 ( 0.6A) TYR A 196 ( 1.3A) THR A 209 ( 0.8A)	1.44A	1uw6P-5hfiA: undetectable 1uw6T-5hfiA: undetectable	1uw6P-5hfiA: 18.70 1uw6T-5hfiA: 18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ACL_G_REAG501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5hfi	UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM (Pseudomonas aeruginosa)	5 / 12	ALA A 149 ALA A 147 LEU A 134 LEU A 105 ALA A 101	ALA A 149 ( 0.0A) ALA A 147 ( 0.0A) LEU A 134 ( 0.6A) LEU A 105 ( 0.6A) ALA A 101 ( 0.0A)	0.94A	2aclG-5hfiA: undetectable	2aclG-5hfiA: 20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FC6_C_REAC501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5hfi	UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM (Pseudomonas aeruginosa)	5 / 12	ALA A 149 ALA A 147 LEU A 134 LEU A 105 ALA A 101	ALA A 149 ( 0.0A) ALA A 147 ( 0.0A) LEU A 134 ( 0.6A) LEU A 105 ( 0.6A) ALA A 101 ( 0.0A)	0.95A	3fc6C-5hfiA: undetectable	3fc6C-5hfiA: 20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OU6_D_SAMD300_0 (SAM-DEPENDENT METHYLTRANSFERASE)	5hfi	UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM (Pseudomonas aeruginosa)	5 / 12	TYR A 8 GLU A 29 ALA A 27 LEU A 207 TRP A 203	TYR A 8 ( 1.3A) GLU A 29 ( 0.6A) ALA A 27 ( 0.0A) LEU A 207 ( 0.6A) TRP A 203 ( 0.5A)	1.41A	3ou6D-5hfiA: undetectable	3ou6D-5hfiA: 25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WDM_B_ADNB301_1 (4-PHOSPHOPANTOATE--B ETA-ALANINE LIGASE)	5hfi	UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM (Pseudomonas aeruginosa)	5 / 10	ALA A 93 LEU A 133 ASP A 11 LEU A 13 ILE A 116	ALA A 93 ( 0.0A) LEU A 133 ( 0.6A) ASP A 11 ( 0.5A) LEU A 13 ( 0.6A) ILE A 116 ( 0.7A)	1.19A	3wdmB-5hfiA: undetectable	3wdmB-5hfiA: 23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WDM_D_ADND301_1 (4-PHOSPHOPANTOATE--B ETA-ALANINE LIGASE)	5hfi	UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM (Pseudomonas aeruginosa)	5 / 10	ALA A 93 LEU A 133 ASP A 11 LEU A 13 ILE A 116	ALA A 93 ( 0.0A) LEU A 133 ( 0.6A) ASP A 11 ( 0.5A) LEU A 13 ( 0.6A) ILE A 116 ( 0.7A)	1.17A	3wdmD-5hfiA: undetectable	3wdmD-5hfiA: 23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ODR_B_FK5B201_1 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1A CHIMERA)	5hfi	UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM (Pseudomonas aeruginosa)	5 / 11	PRO A 95 TYR A 10 LEU A 37 LEU A 24 ILE A 127	PRO A 95 ( 1.1A) TYR A 10 ( 1.3A) LEU A 37 ( 0.5A) LEU A 24 ( 0.6A) ILE A 127 ( 0.7A)	1.09A	4odrA-5hfiA: undetectable 4odrB-5hfiA: undetectable	4odrA-5hfiA: 18.49 4odrB-5hfiA: 18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UCI_B_ADNB2415_1 (RNA-DIRECTED RNA POLYMERASE L)	5hfi	UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM (Pseudomonas aeruginosa)	4 / 7	PHE A 79 PHE A 74 TYR A 18 HIS A 120	PHE A 79 ( 1.3A) PHE A 74 ( 1.3A) TYR A 18 ( 1.3A) HIS A 120 ( 1.0A)	1.12A	4uciB-5hfiA: undetectable	4uciB-5hfiA: 20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSD_B_1GNB603_1 (PHIAB6 TAILSPIKE)	5hfi	UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM (Pseudomonas aeruginosa)	3 / 3	VAL A 122 GLU A 135 GLU A 139	VAL A 122 ( 0.6A) GLU A 135 ( 0.6A) GLU A 139 ( 0.6A)	0.82A	5jsdB-5hfiA: undetectable 5jsdC-5hfiA: undetectable	5jsdB-5hfiA: 15.74 5jsdC-5hfiA: 15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NWW_A_ACAA18_1 (SCRFP-TAG,GP41)	5hfi	UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM (Pseudomonas aeruginosa)	5 / 12	GLY A 124 LEU A 133 LEU A 134 GLU A 135 LEU A 136	GLY A 124 ( 0.0A) LEU A 133 ( 0.6A) LEU A 134 ( 0.6A) GLU A 135 ( 0.6A) LEU A 136 ( 0.6A)	0.72A	5nwwA-5hfiA: undetectable	5nwwA-5hfiA: 10.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1BZF_A_TMQA170_1","DIHYDROFOLATE REDUCTASE","5hfi","UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM","Pseudomonas aeruginosa",5,"ALA A  27;HIS A   7;LEU A   6;LEU A 191;ALA A  20","ALA A  27 ( 0.0A);HIS A   7 ( 1.0A);LEU A   6 ( 0.6A);LEU A 191 ( 0.6A);ALA A  20 ( 0.0A)","1.09A","1bzfA-5hfiA:undetectable","1bzfA-5hfiA:23.05"],["1K74_A_9CRA463_1","RETINOIC ACID RECEPTOR RXR-ALPHA","5hfi","UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM","Pseudomonas aeruginosa",5,"ALA A 149;ALA A 147;LEU A 134;LEU A 105;ALA A 101","ALA A 149 ( 0.0A);ALA A 147 ( 0.0A);LEU A 134 ( 0.6A);LEU A 105 ( 0.6A);ALA A 101 ( 0.0A)","0.92A","1k74A-5hfiA:undetectable","1k74A-5hfiA:20.08"],["1P33_A_MTXA351_1","PTERIDINE REDUCTASE 1","5hfi","UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM","Pseudomonas aeruginosa",5,"PHE A 206;LEU A 191;TYR A 196;LEU A  33;LEU A 211","PHE A 206 ( 1.3A);LEU A 191 ( 0.6A);TYR A 196 ( 1.3A);LEU A  33 ( 0.6A);LEU A 211 ( 0.6A)","1.34A","1p33A-5hfiA:undetectable","1p33A-5hfiA:22.92"],["1P33_B_MTXB352_1","PTERIDINE REDUCTASE 1","5hfi","UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM","Pseudomonas aeruginosa",5,"PHE A 206;LEU A 191;TYR A 196;LEU A  33;LEU A 211","PHE A 206 ( 1.3A);LEU A 191 ( 0.6A);TYR A 196 ( 1.3A);LEU A  33 ( 0.6A);LEU A 211 ( 0.6A)","1.33A","1p33B-5hfiA:undetectable","1p33B-5hfiA:22.92"],["1P33_C_MTXC353_1","PTERIDINE REDUCTASE 1","5hfi","UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM","Pseudomonas aeruginosa",5,"PHE A 206;LEU A 191;TYR A 196;LEU A  33;LEU A 211","PHE A 206 ( 1.3A);LEU A 191 ( 0.6A);TYR A 196 ( 1.3A);LEU A  33 ( 0.6A);LEU A 211 ( 0.6A)","1.29A","1p33C-5hfiA:undetectable","1p33C-5hfiA:22.92"],["1UW6_A_NCTA1208_1","ACETYLCHOLINE-BINDING PROTEIN;ACETYLCHOLINE-BINDING PROTEIN","5hfi","UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM","Pseudomonas aeruginosa",4,"TYR A 196;THR A 209;TRP A 203;LEU A   4","TYR A 196 ( 1.3A);THR A 209 ( 0.8A);TRP A 203 ( 0.5A);LEU A   4 ( 0.6A)","1.42A","1uw6A-5hfiA:undetectable;1uw6B-5hfiA:undetectable","1uw6A-5hfiA:18.70;1uw6B-5hfiA:18.70"],["1UW6_T_NCTT1208_1","ACETYLCHOLINE-BINDING PROTEIN;ACETYLCHOLINE-BINDING PROTEIN","5hfi","UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM","Pseudomonas aeruginosa",4,"TRP A 203;LEU A   4;TYR A 196;THR A 209","TRP A 203 ( 0.5A);LEU A   4 ( 0.6A);TYR A 196 ( 1.3A);THR A 209 ( 0.8A)","1.44A","1uw6P-5hfiA:undetectable;1uw6T-5hfiA:undetectable","1uw6P-5hfiA:18.70;1uw6T-5hfiA:18.70"],["2ACL_G_REAG501_1","RETINOIC ACID RECEPTOR RXR-ALPHA","5hfi","UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM","Pseudomonas aeruginosa",5,"ALA A 149;ALA A 147;LEU A 134;LEU A 105;ALA A 101","ALA A 149 ( 0.0A);ALA A 147 ( 0.0A);LEU A 134 ( 0.6A);LEU A 105 ( 0.6A);ALA A 101 ( 0.0A)","0.94A","2aclG-5hfiA:undetectable","2aclG-5hfiA:20.08"],["3FC6_C_REAC501_1","RETINOIC ACID RECEPTOR RXR-ALPHA","5hfi","UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM","Pseudomonas aeruginosa",5,"ALA A 149;ALA A 147;LEU A 134;LEU A 105;ALA A 101","ALA A 149 ( 0.0A);ALA A 147 ( 0.0A);LEU A 134 ( 0.6A);LEU A 105 ( 0.6A);ALA A 101 ( 0.0A)","0.95A","3fc6C-5hfiA:undetectable","3fc6C-5hfiA:20.53"],["3OU6_D_SAMD300_0","SAM-DEPENDENT METHYLTRANSFERASE","5hfi","UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM","Pseudomonas aeruginosa",5,"TYR A   8;GLU A  29;ALA A  27;LEU A 207;TRP A 203","TYR A   8 ( 1.3A);GLU A  29 ( 0.6A);ALA A  27 ( 0.0A);LEU A 207 ( 0.6A);TRP A 203 ( 0.5A)","1.41A","3ou6D-5hfiA:undetectable","3ou6D-5hfiA:25.10"],["3WDM_B_ADNB301_1","4-PHOSPHOPANTOATE--BETA-ALANINE LIGASE","5hfi","UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM","Pseudomonas aeruginosa",5,"ALA A  93;LEU A 133;ASP A  11;LEU A  13;ILE A 116","ALA A  93 ( 0.0A);LEU A 133 ( 0.6A);ASP A  11 ( 0.5A);LEU A  13 ( 0.6A);ILE A 116 ( 0.7A)","1.19A","3wdmB-5hfiA:undetectable","3wdmB-5hfiA:23.72"],["3WDM_D_ADND301_1","4-PHOSPHOPANTOATE--BETA-ALANINE LIGASE","5hfi","UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM","Pseudomonas aeruginosa",5,"ALA A  93;LEU A 133;ASP A  11;LEU A  13;ILE A 116","ALA A  93 ( 0.0A);LEU A 133 ( 0.6A);ASP A  11 ( 0.5A);LEU A  13 ( 0.6A);ILE A 116 ( 0.7A)","1.17A","3wdmD-5hfiA:undetectable","3wdmD-5hfiA:23.72"],["4ODR_B_FK5B201_1","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1A CHIMERA;PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1A CHIMERA","5hfi","UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM","Pseudomonas aeruginosa",5,"PRO A  95;TYR A  10;LEU A  37;LEU A  24;ILE A 127","PRO A  95 ( 1.1A);TYR A  10 ( 1.3A);LEU A  37 ( 0.5A);LEU A  24 ( 0.6A);ILE A 127 ( 0.7A)","1.09A","4odrA-5hfiA:undetectable;4odrB-5hfiA:undetectable","4odrA-5hfiA:18.49;4odrB-5hfiA:18.49"],["4UCI_B_ADNB2415_1","RNA-DIRECTED RNA POLYMERASE L","5hfi","UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM","Pseudomonas aeruginosa",4,"PHE A  79;PHE A  74;TYR A  18;HIS A 120","PHE A  79 ( 1.3A);PHE A  74 ( 1.3A);TYR A  18 ( 1.3A);HIS A 120 ( 1.0A)","1.12A","4uciB-5hfiA:undetectable","4uciB-5hfiA:20.80"],["5JSD_B_1GNB603_1","PHIAB6 TAILSPIKE;PHIAB6 TAILSPIKE","5hfi","UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM","Pseudomonas aeruginosa",3,"VAL A 122;GLU A 135;GLU A 139","VAL A 122 ( 0.6A);GLU A 135 ( 0.6A);GLU A 139 ( 0.6A)","0.82A","5jsdB-5hfiA:undetectable;5jsdC-5hfiA:undetectable","5jsdB-5hfiA:15.74;5jsdC-5hfiA:15.74"],["5NWW_A_ACAA18_1","SCRFP-TAG,GP41","5hfi","UNCHARACTERIZED PROTEIN, CYTOSOLIC DISULFIDE REDUCTASE DSBM","Pseudomonas aeruginosa",5,"GLY A 124;LEU A 133;LEU A 134;GLU A 135;LEU A 136","GLY A 124 ( 0.0A);LEU A 133 ( 0.6A);LEU A 134 ( 0.6A);GLU A 135 ( 0.6A);LEU A 136 ( 0.6A)","0.72A","5nwwA-5hfiA:undetectable","5nwwA-5hfiA:10.00"]]