SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hfj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		6 / 12 ASP A  29
PHE A 195
GLY A 197
SER A 198
THR A 200
TYR A 221
 SAM  A 301 (-3.2A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-2.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.2A)
 0.48A 1g60A-5hfjA:
22.9		 1g60A-5hfjA:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_B_SAMB501_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		5 / 12 ASP A  29
PHE A 195
GLY A 197
THR A 200
TYR A 221
 SAM  A 301 (-3.2A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.2A)
 0.43A 1g60B-5hfjA:
23.1		 1g60B-5hfjA:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_B_ESTB600_1
(OESTROGEN RECEPTOR)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		5 / 9 LEU A 208
ALA A 204
GLU A 178
LEU A 174
LEU A 229
 None
 1.37A 1gwrB-5hfjA:
undetectable		 1gwrB-5hfjA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		5 / 12 ASP A   8
PRO A  31
PHE A 195
GLY A 197
SER A 198
 SAM  A 301 (-3.4A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-2.5A)
 0.61A 1nw5A-5hfjA:
21.5		 1nw5A-5hfjA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		5 / 10 ASP A 193
GLY A 199
GLY A 197
ILE A 181
ALA A 204
 None
None
SAM  A 301 (-3.4A)
None
None
 0.99A 1x7pA-5hfjA:
undetectable
1x7pB-5hfjA:
undetectable		 1x7pA-5hfjA:
20.07
1x7pB-5hfjA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		4 / 5 ILE A  12
ASP A 193
ALA A   9
PHE A 212
 None
None
SAM  A 301 (-3.2A)
None
 1.03A 2opxA-5hfjA:
2.1		 2opxA-5hfjA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		5 / 12 LEU A  95
ILE A  91
ALA A  70
VAL A  73
THR A  28
 None
 1.38A 2qo4A-5hfjA:
undetectable		 2qo4A-5hfjA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		6 / 12 ALA A   9
PRO A  31
PHE A 195
GLY A 197
THR A 200
GLU A 216
 SAM  A 301 (-3.2A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.1A)
 0.55A 2zifA-5hfjA:
19.5		 2zifA-5hfjA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		5 / 12 ALA A   9
PRO A  31
PHE A 195
GLY A 197
TYR A 221
 SAM  A 301 (-3.2A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.2A)
 0.43A 2zifB-5hfjA:
19.9		 2zifB-5hfjA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		5 / 11 GLY A 197
ILE A 215
ASP A   8
ALA A   9
PHE A  82
 SAM  A 301 (-3.4A)
SAM  A 301 ( 4.9A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.2A)
None
 0.91A 3dxyA-5hfjA:
4.5		 3dxyA-5hfjA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		5 / 11 GLY A 197
ILE A 215
GLU A 216
ASP A   8
ALA A   9
 SAM  A 301 (-3.4A)
SAM  A 301 ( 4.9A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.2A)
 0.69A 3dxyA-5hfjA:
4.5		 3dxyA-5hfjA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		4 / 6 GLY A 197
THR A 201
GLU A 216
GLU A 218
 SAM  A 301 (-3.4A)
None
SAM  A 301 (-3.1A)
None
 0.81A 3fpjA-5hfjA:
2.7		 3fpjA-5hfjA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		5 / 12 GLY A 197
GLU A 216
ASP A   8
ALA A   9
PRO A  31
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.2A)
SAM  A 301 ( 4.0A)
 0.86A 3fuuA-5hfjA:
3.5		 3fuuA-5hfjA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		4 / 5 SER A 198
THR A 200
GLU A 216
ASP A   8
 SAM  A 301 (-2.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.4A)
 0.43A 3tm4A-5hfjA:
undetectable		 3tm4A-5hfjA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		4 / 5 SER A 198
THR A 200
GLU A 216
ASP A   8
 SAM  A 301 (-2.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.4A)
 0.37A 3tm4B-5hfjA:
undetectable		 3tm4B-5hfjA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		5 / 12 GLY A 197
SER A 198
THR A 200
SER A 217
PRO A  31
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-2.8A)
SAM  A 301 ( 4.0A)
 0.65A 3v8vA-5hfjA:
4.1		 3v8vA-5hfjA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		4 / 6 GLY A 197
GLU A 216
ASP A   8
ASP A  29
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.2A)
 0.87A 3vywC-5hfjA:
3.7		 3vywC-5hfjA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		5 / 10 LEU A 208
ALA A 204
GLU A 178
LEU A 174
LEU A 229
 None
 1.38A 5dx3A-5hfjA:
undetectable		 5dx3A-5hfjA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		5 / 12 PHE A 195
ALA A   9
THR A  28
ASP A  29
PRO A  31
 SAM  A 301 (-4.6A)
SAM  A 301 (-3.2A)
None
SAM  A 301 (-3.2A)
SAM  A 301 ( 4.0A)
 0.78A 5e72A-5hfjA:
5.5		 5e72A-5hfjA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		5 / 12 PHE A 195
GLY A 199
THR A  28
ASP A  29
PRO A  31
 SAM  A 301 (-4.6A)
None
None
SAM  A 301 (-3.2A)
SAM  A 301 ( 4.0A)
 0.90A 5e72A-5hfjA:
5.5		 5e72A-5hfjA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		3 / 3 ILE A  13
MET A 196
ASP A   8
 None
None
SAM  A 301 (-3.4A)
 0.71A 5h2uA-5hfjA:
undetectable		 5h2uA-5hfjA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		12 / 12 ASP A   8
ALA A   9
ASP A  29
PRO A  31
LYS A 167
PHE A 195
GLY A 197
THR A 200
GLU A 216
SER A 217
GLU A 218
TYR A 221
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.2A)
SAM  A 301 (-3.2A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-4.1A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.8A)
None
SAM  A 301 (-4.2A)
 0.01A 5hfjA-5hfjA:
39.6		 5hfjA-5hfjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		7 / 12 ASP A  29
PRO A  31
GLY A 197
THR A 201
GLU A 216
SER A 217
GLU A 218
 SAM  A 301 (-3.2A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-3.4A)
None
SAM  A 301 (-3.1A)
SAM  A 301 (-2.8A)
None
 1.38A 5hfjA-5hfjA:
39.6		 5hfjA-5hfjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		5 / 12 ALA A   7
GLY A 197
SER A 198
THR A 200
TYR A 221
 None
SAM  A 301 (-3.4A)
SAM  A 301 (-2.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.2A)
 0.98A 5hfjB-5hfjA:
33.5		 5hfjB-5hfjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		9 / 12 ALA A   9
ASP A  29
PRO A  31
PHE A 195
GLY A 197
SER A 198
THR A 200
SER A 217
TYR A 221
 SAM  A 301 (-3.2A)
SAM  A 301 (-3.2A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-2.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-2.8A)
SAM  A 301 (-4.2A)
 0.66A 5hfjB-5hfjA:
33.5		 5hfjB-5hfjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		9 / 12 ASP A   8
ALA A   9
PRO A  31
PHE A 195
GLY A 197
THR A 200
SER A 217
GLU A 218
TYR A 221
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.2A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-2.8A)
None
SAM  A 301 (-4.2A)
 0.22A 5hfjC-5hfjA:
35.1		 5hfjC-5hfjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		5 / 12 PRO A  31
GLY A 197
THR A 201
SER A 217
GLU A 218
 SAM  A 301 ( 4.0A)
SAM  A 301 (-3.4A)
None
SAM  A 301 (-2.8A)
None
 1.39A 5hfjC-5hfjA:
35.1		 5hfjC-5hfjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		6 / 12 ASP A   8
ALA A   7
PRO A 194
GLY A 197
SER A 198
GLU A 216
 SAM  A 301 (-3.4A)
None
None
SAM  A 301 (-3.4A)
SAM  A 301 (-2.5A)
SAM  A 301 (-3.1A)
 1.40A 5hfjD-5hfjA:
32.1		 5hfjD-5hfjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		11 / 12 ASP A   8
ALA A   9
ASP A  29
PRO A  31
PHE A 195
GLY A 197
SER A 198
THR A 200
GLU A 216
GLU A 218
TYR A 221
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.2A)
SAM  A 301 (-3.2A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-2.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.1A)
None
SAM  A 301 (-4.2A)
 0.45A 5hfjD-5hfjA:
32.1		 5hfjD-5hfjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		10 / 12 ASP A   8
ALA A   9
ASP A  29
PRO A  31
PHE A 195
GLY A 197
SER A 198
THR A 200
GLU A 216
SER A 217
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.2A)
SAM  A 301 (-3.2A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-2.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.8A)
 0.66A 5hfjD-5hfjA:
32.1		 5hfjD-5hfjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		10 / 12 ASP A   8
ALA A   9
ASP A  29
PHE A 195
GLY A 197
SER A 198
THR A 200
GLU A 216
SER A 217
TYR A 221
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.2A)
SAM  A 301 (-3.2A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-2.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.8A)
SAM  A 301 (-4.2A)
 0.33A 5hfjE-5hfjA:
32.9		 5hfjE-5hfjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		10 / 12 ASP A   8
ALA A   9
ASP A  29
PRO A  31
PHE A 195
GLY A 197
SER A 198
GLU A 216
SER A 217
TYR A 221
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.2A)
SAM  A 301 (-3.2A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-2.5A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.8A)
SAM  A 301 (-4.2A)
 0.57A 5hfjF-5hfjA:
33.6		 5hfjF-5hfjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		5 / 12 ALA A   7
GLY A 197
THR A 200
GLU A 218
TYR A 221
 None
SAM  A 301 (-3.4A)
SAM  A 301 (-3.6A)
None
SAM  A 301 (-4.2A)
 1.13A 5hfjG-5hfjA:
34.2		 5hfjG-5hfjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		8 / 12 ALA A   9
ASP A  29
PRO A  31
PHE A 195
GLY A 197
THR A 200
GLU A 218
TYR A 221
 SAM  A 301 (-3.2A)
SAM  A 301 (-3.2A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.6A)
None
SAM  A 301 (-4.2A)
 0.32A 5hfjG-5hfjA:
34.2		 5hfjG-5hfjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		8 / 12 ASP A  29
PRO A  31
PHE A 195
GLY A 197
THR A 200
SER A 217
GLU A 218
TYR A 221
 SAM  A 301 (-3.2A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-2.8A)
None
SAM  A 301 (-4.2A)
 0.61A 5hfjG-5hfjA:
34.2		 5hfjG-5hfjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		7 / 12 ALA A   9
ASP A  29
PRO A  31
PHE A 195
GLY A 197
THR A 200
SER A 217
 SAM  A 301 (-3.2A)
SAM  A 301 (-3.2A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-2.8A)
 0.66A 5hfjH-5hfjA:
33.2		 5hfjH-5hfjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		8 / 12 ASP A   8
ALA A   9
ASP A  29
PRO A  31
PHE A 195
GLY A 197
THR A 200
TYR A 221
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.2A)
SAM  A 301 (-3.2A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.2A)
 0.37A 5hfjH-5hfjA:
33.2		 5hfjH-5hfjA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		5 / 11 PHE A 195
GLY A 197
GLU A 216
ASP A   8
PRO A  31
 SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.4A)
SAM  A 301 ( 4.0A)
 0.53A 5hjiA-5hfjA:
3.7		 5hjiA-5hfjA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		5 / 11 LEU A 208
ALA A 204
GLU A 178
LEU A 174
LEU A 229
 None
 1.42A 5hyrB-5hfjA:
undetectable		 5hyrB-5hfjA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		3 / 3 LEU A  95
ILE A  66
TYR A  32
 None
 0.70A 5uunB-5hfjA:
undetectable		 5uunB-5hfjA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		4 / 7 ARG A 210
PHE A 212
LEU A 229
SER A 198
 None
None
None
SAM  A 301 (-2.5A)
 0.84A 5uxcA-5hfjA:
undetectable		 5uxcA-5hfjA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		5 / 10 LEU A 208
ALA A 204
GLU A 178
LEU A 174
LEU A 229
 None
 1.41A 6cbzB-5hfjA:
undetectable		 6cbzB-5hfjA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)
(Helicobacter
pylori) 		5 / 12 ASN A 207
ILE A 181
ILE A 180
VAL A 191
ILE A  27
 None
 0.91A 6hlpA-5hfjA:
2.5		 6hlpA-5hfjA:
15.90