SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hfn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 5hfn CEPHALOSPORIN-C
DEACETYLASE
(Thermotoga
maritima) 		3 / 3 ALA A 167
VAL A 114
TRP A  72
 None
 0.92A 1tkqB-5hfnA:
undetectable		 1tkqB-5hfnA:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 5hfn CEPHALOSPORIN-C
DEACETYLASE
(Thermotoga
maritima) 		4 / 4 ILE A 111
GLN A 176
VAL A  75
PHE A 174
 None
 1.37A 3ieoA-5hfnA:
undetectable		 3ieoA-5hfnA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 5hfn CEPHALOSPORIN-C
DEACETYLASE
(Thermotoga
maritima) 		3 / 3 LEU A  51
LYS A  52
THR A  53
 None
 0.54A 4lj0A-5hfnA:
undetectable		 4lj0A-5hfnA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5hfn CEPHALOSPORIN-C
DEACETYLASE
(Thermotoga
maritima) 		5 / 11 ILE A 111
GLN A 179
PHE A 174
ALA A 172
VAL A  54
 None
 1.01A 4nqaA-5hfnA:
undetectable		 4nqaA-5hfnA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5hfn CEPHALOSPORIN-C
DEACETYLASE
(Thermotoga
maritima) 		5 / 12 GLY A 186
ALA A 185
VAL A 312
TRP A 105
GLN A  88
 None
 1.40A 4ryaA-5hfnA:
undetectable		 4ryaA-5hfnA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 5hfn CEPHALOSPORIN-C
DEACETYLASE
(Thermotoga
maritima) 		3 / 3 ASP A  23
SER A 251
TYR A 252
 None
 0.92A 5glmA-5hfnA:
undetectable		 5glmA-5hfnA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5hfn CEPHALOSPORIN-C
DEACETYLASE
(Thermotoga
maritima) 		3 / 3 GLU A  21
TYR A  19
ARG A 218
 None
 0.54A 5uunA-5hfnA:
undetectable		 5uunA-5hfnA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5hfn CEPHALOSPORIN-C
DEACETYLASE
(Thermotoga
maritima) 		3 / 3 GLU A  21
TYR A  19
ARG A 218
 None
 0.70A 5uunB-5hfnA:
undetectable		 5uunB-5hfnA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 5hfn CEPHALOSPORIN-C
DEACETYLASE
(Thermotoga
maritima) 		4 / 8 PRO A  16
ALA A 220
THR A 281
ALA A 259
 None
 0.99A 5x2tI-5hfnA:
undetectable
5x2tJ-5hfnA:
undetectable
5x2tK-5hfnA:
undetectable
5x2tL-5hfnA:
undetectable		 5x2tI-5hfnA:
18.97
5x2tJ-5hfnA:
18.41
5x2tK-5hfnA:
18.97
5x2tL-5hfnA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5hfn CEPHALOSPORIN-C
DEACETYLASE
(Thermotoga
maritima) 		5 / 10 PHE A 268
GLY A 187
ILE A 184
ALA A 194
LEU A 195
 None
 1.15A 5zjiA-5hfnA:
undetectable
5zjiJ-5hfnA:
undetectable		 5zjiA-5hfnA:
12.54
5zjiJ-5hfnA:
8.44