SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hft'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae) 		5 / 11 ILE A 136
ALA A 129
SER A 202
LEU A 208
PRO A 207
 None
 1.06A 1dg5A-5hftA:
undetectable		 1dg5A-5hftA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae) 		5 / 12 LEU B 470
THR A 288
VAL A 285
ALA B 434
ALA B 433
 None
 1.09A 1n5xA-5hftB:
undetectable		 1n5xA-5hftB:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae) 		5 / 12 LEU B 470
THR A 288
VAL A 285
ALA B 434
ALA B 433
 None
 1.09A 1n5xB-5hftB:
undetectable		 1n5xB-5hftB:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae) 		4 / 4 ALA B 524
VAL A  13
ALA A  14
HIS A  16
 None
 1.08A 1q23A-5hftB:
undetectable		 1q23A-5hftB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae) 		4 / 4 ALA B 524
VAL A  13
ALA A  14
HIS A  16
 None
 1.23A 1q23F-5hftB:
undetectable		 1q23F-5hftB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae) 		4 / 4 ALA B 524
VAL A  13
ALA A  14
HIS A  16
 None
 1.12A 1q23K-5hftB:
undetectable		 1q23K-5hftB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae) 		5 / 10 ALA A 125
LEU A 132
LEU A 200
SER A 118
LEU A 115
 None
 1.36A 2ceoB-5hftA:
undetectable		 2ceoB-5hftA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae) 		4 / 7 ALA A 287
THR A 288
ALA A 291
ARG A 295
 None
 0.99A 2ql8A-5hftA:
undetectable
2ql8B-5hftA:
undetectable		 2ql8A-5hftA:
16.44
2ql8B-5hftA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		4 / 6 ARG A 295
THR A 288
ALA A 291
PRO B 429
 None
 1.41A 2ql8A-5hftA:
undetectable
2ql8B-5hftA:
undetectable		 2ql8A-5hftA:
16.44
2ql8B-5hftA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae) 		5 / 9 ALA A  43
ALA A  41
GLY B 346
SER A  22
ALA A  23
 None
 1.09A 2vh3A-5hftA:
undetectable		 2vh3A-5hftA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		4 / 8 ARG B 416
TYR B 439
ASP A 268
GLN A 244
 None
 1.28A 3dh0A-5hftB:
undetectable		 3dh0A-5hftB:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae) 		4 / 8 HIS A 231
LEU A 132
LEU A  54
SER A 109
 None
 0.98A 3lm8B-5hftA:
undetectable
3lm8D-5hftA:
undetectable		 3lm8B-5hftA:
18.03
3lm8D-5hftA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A  54
LEU B 371
TRP A 111
GLY A 106
ALA A 105
 None
 1.10A 3pghA-5hftA:
undetectable		 3pghA-5hftA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae) 		5 / 11 LEU A  54
LEU B 371
TRP A 111
GLY A 106
ALA A 105
 None
 1.13A 3pghB-5hftA:
undetectable		 3pghB-5hftA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		4 / 8 ALA A  45
GLY A  53
GLN B 359
THR A 107
 None
 0.89A 3rglA-5hftA:
undetectable		 3rglA-5hftA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A 208
GLY A 110
LEU A 195
GLY A  76
ASP A  57
 None
 0.88A 4dc3A-5hftA:
undetectable		 4dc3A-5hftA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A 212
GLY A  55
ALA A 105
ILE A 223
ARG A  96
 None
 1.22A 4hytA-5hftA:
undetectable		 4hytA-5hftA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A 212
GLY A  55
ALA A 105
ILE A 223
ARG A  96
 None
 1.22A 4hytC-5hftA:
undetectable		 4hytC-5hftA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae) 		4 / 6 ALA A 114
ILE A  26
ILE A  62
VAL B 347
 None
 0.77A 4r21A-5hftA:
undetectable		 4r21A-5hftA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae) 		4 / 8 LEU A 251
GLY A  58
ALA A  74
SER A  75
 None
 0.80A 5f1aA-5hftA:
undetectable		 5f1aA-5hftA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae) 		5 / 12 PHE B 357
LEU B 405
GLY B 421
VAL B 343
THR B 342
 None
 1.25A 5o4yD-5hftB:
undetectable
5o4yE-5hftB:
undetectable		 5o4yD-5hftB:
3.74
5o4yE-5hftB:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		5 / 12 ALA A  43
LEU A  54
VAL B 343
TYR B 362
ASP A  57
 None
 1.29A 5vlmD-5hftA:
undetectable		 5vlmD-5hftA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		3 / 3 GLN A 185
TRP A 170
VAL B 370
 None
 0.87A 6auuA-5hftA:
undetectable		 6auuA-5hftA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		4 / 6 THR A 103
GLY A  76
ARG B 381
ARG A 234
 None
 1.25A 6gtqB-5hftA:
undetectable
6gtqD-5hftA:
undetectable		 6gtqB-5hftA:
18.08
6gtqD-5hftA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE
(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		4 / 8 ILE B 361
ALA A 105
VAL A 104
ARG B 381
 None
 1.07A 6hu9a-5hftB:
undetectable
6hu9e-5hftB:
undetectable		 6hu9a-5hftB:
16.79
6hu9e-5hftB:
21.16