SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hg0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5hg0 PANTOTHENATE
SYNTHETASE
(Francisella
tularensis) 		5 / 12 HIS A  33
GLY A  35
HIS A  36
GLY A 147
ASP A 150
 SAM  A 301 (-4.5A)
SAM  A 301 ( 3.7A)
SAM  A 301 (-4.0A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.2A)
 0.97A 1qu2A-5hg0A:
undetectable		 1qu2A-5hg0A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5hg0 PANTOTHENATE
SYNTHETASE
(Francisella
tularensis) 		4 / 6 ASP A 150
VAL A 154
ILE A 157
TYR A  70
 SAM  A 301 (-4.2A)
None
None
None
 1.01A 1s9qA-5hg0A:
undetectable		 1s9qA-5hg0A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 5hg0 PANTOTHENATE
SYNTHETASE
(Francisella
tularensis) 		4 / 5 ASP A 209
THR A 218
LEU A 214
LEU A 217
 None
 1.22A 1u18B-5hg0A:
undetectable		 1u18B-5hg0A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5hg0 PANTOTHENATE
SYNTHETASE
(Francisella
tularensis) 		4 / 5 ALA A   4
ASN A   6
ILE A   7
ASP A  96
 None
 1.14A 1yc2D-5hg0A:
undetectable		 1yc2D-5hg0A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5hg0 PANTOTHENATE
SYNTHETASE
(Francisella
tularensis) 		4 / 6 LEU A 182
ASN A 188
ILE A 196
ALA A 199
 None
 1.09A 2j5mA-5hg0A:
undetectable		 2j5mA-5hg0A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 5hg0 PANTOTHENATE
SYNTHETASE
(Francisella
tularensis) 		3 / 3 LEU A  17
ASN A  15
ARG A  14
 None
 0.86A 2qhfA-5hg0A:
undetectable		 2qhfA-5hg0A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 5hg0 PANTOTHENATE
SYNTHETASE
(Francisella
tularensis) 		5 / 12 HIS A  33
GLY A  35
HIS A  36
GLY A 147
ASP A 150
 SAM  A 301 (-4.5A)
SAM  A 301 ( 3.7A)
SAM  A 301 (-4.0A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.2A)
 0.94A 2x1lB-5hg0A:
undetectable		 2x1lB-5hg0A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 5hg0 PANTOTHENATE
SYNTHETASE
(Francisella
tularensis) 		5 / 11 HIS A  33
GLY A  35
HIS A  36
GLY A 147
ASP A 150
 SAM  A 301 (-4.5A)
SAM  A 301 ( 3.7A)
SAM  A 301 (-4.0A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.2A)
 0.97A 2x1lC-5hg0A:
6.1		 2x1lC-5hg0A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 5hg0 PANTOTHENATE
SYNTHETASE
(Francisella
tularensis) 		4 / 6 GLN A 153
HIS A  36
HIS A  33
ASP A 150
 SAM  A 301 (-3.0A)
SAM  A 301 (-4.0A)
SAM  A 301 (-4.5A)
SAM  A 301 (-4.2A)
 1.07A 3nvcA-5hg0A:
undetectable		 3nvcA-5hg0A:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 5hg0 PANTOTHENATE
SYNTHETASE
(Francisella
tularensis) 		4 / 8 ARG A 121
HIS A 124
VAL A 132
ARG A 187
 None
 0.95A 3uy4A-5hg0A:
26.8		 3uy4A-5hg0A:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 5hg0 PANTOTHENATE
SYNTHETASE
(Francisella
tularensis) 		7 / 8 GLN A  60
ARG A 121
HIS A 124
VAL A 131
ASP A 150
GLN A 153
ARG A 187
 SAM  A 301 (-3.5A)
None
None
None
SAM  A 301 (-4.2A)
SAM  A 301 (-3.0A)
None
 0.39A 3uy4A-5hg0A:
26.8		 3uy4A-5hg0A:
36.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5hg0 PANTOTHENATE
SYNTHETASE
(Francisella
tularensis) 		3 / 3 SER A 180
ASP A 251
ASP A 150
 None
None
SAM  A 301 (-4.2A)
 0.75A 4mwzA-5hg0A:
2.3		 4mwzA-5hg0A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5hg0 PANTOTHENATE
SYNTHETASE
(Francisella
tularensis) 		3 / 3 SER A 186
TYR A  70
ASP A  77
 SAM  A 301 ( 4.6A)
None
None
 0.86A 4rp8C-5hg0A:
undetectable		 4rp8C-5hg0A:
18.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 5hg0 PANTOTHENATE
SYNTHETASE
(Francisella
tularensis) 		12 / 12 HIS A  33
GLY A  35
LEU A  39
GLN A  60
TYR A  70
VAL A 131
GLY A 147
LYS A 149
ASP A 150
THR A 175
GLN A 176
LEU A 184
 SAM  A 301 (-4.5A)
SAM  A 301 ( 3.7A)
SAM  A 301 ( 4.8A)
SAM  A 301 (-3.5A)
None
None
SAM  A 301 (-3.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.2A)
SAM  A 301 (-4.2A)
None
SAM  A 301 (-4.3A)
 0.03A 5hg0A-5hg0A:
46.0		 5hg0A-5hg0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 5hg0 PANTOTHENATE
SYNTHETASE
(Francisella
tularensis) 		5 / 12 HIS A  33
GLY A  35
VAL A 132
ASP A 150
LEU A 184
 SAM  A 301 (-4.5A)
SAM  A 301 ( 3.7A)
None
SAM  A 301 (-4.2A)
SAM  A 301 (-4.3A)
 1.16A 5hg0A-5hg0A:
46.0		 5hg0A-5hg0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 5hg0 PANTOTHENATE
SYNTHETASE
(Francisella
tularensis) 		6 / 12 HIS A  36
GLY A  35
TYR A  70
GLY A 147
LYS A 149
ASP A 150
 SAM  A 301 (-4.0A)
SAM  A 301 ( 3.7A)
None
SAM  A 301 (-3.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.2A)
 1.37A 5hg0A-5hg0A:
46.0		 5hg0A-5hg0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 5hg0 PANTOTHENATE
SYNTHETASE
(Francisella
tularensis) 		12 / 12 HIS A  33
GLY A  35
HIS A  36
LEU A  39
TYR A  70
VAL A 131
GLY A 147
LYS A 149
ASP A 150
THR A 175
GLN A 176
LEU A 184
 SAM  A 301 (-4.5A)
SAM  A 301 ( 3.7A)
SAM  A 301 (-4.0A)
SAM  A 301 ( 4.8A)
None
None
SAM  A 301 (-3.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.2A)
SAM  A 301 (-4.2A)
None
SAM  A 301 (-4.3A)
 0.20A 5hg0B-5hg0A:
43.0		 5hg0B-5hg0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 5hg0 PANTOTHENATE
SYNTHETASE
(Francisella
tularensis) 		7 / 12 HIS A  33
GLY A  35
HIS A  36
VAL A 132
LYS A 149
ASP A 150
LEU A 184
 SAM  A 301 (-4.5A)
SAM  A 301 ( 3.7A)
SAM  A 301 (-4.0A)
None
SAM  A 301 (-3.4A)
SAM  A 301 (-4.2A)
SAM  A 301 (-4.3A)
 1.09A 5hg0B-5hg0A:
43.0		 5hg0B-5hg0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 5hg0 PANTOTHENATE
SYNTHETASE
(Francisella
tularensis) 		6 / 12 HIS A  36
GLY A  35
TYR A  70
GLY A 147
ASP A 150
GLN A 176
 SAM  A 301 (-4.0A)
SAM  A 301 ( 3.7A)
None
SAM  A 301 (-3.1A)
SAM  A 301 (-4.2A)
None
 1.44A 5hg0B-5hg0A:
43.0		 5hg0B-5hg0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 5hg0 PANTOTHENATE
SYNTHETASE
(Francisella
tularensis) 		5 / 11 TYR A 203
ASP A 251
ARG A 177
ILE A 244
ILE A 250
 None
 1.23A 5hw8D-5hg0A:
undetectable		 5hw8D-5hg0A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 5hg0 PANTOTHENATE
SYNTHETASE
(Francisella
tularensis) 		4 / 8 ILE A 171
LEU A 136
ILE A 166
LEU A  39
 None
None
None
SAM  A 301 ( 4.8A)
 1.00A 5ieoA-5hg0A:
undetectable		 5ieoA-5hg0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 5hg0 PANTOTHENATE
SYNTHETASE
(Francisella
tularensis) 		5 / 12 LEU A  32
SER A  38
GLY A  35
VAL A  26
THR A  28
 None
SAM  A 301 ( 4.6A)
SAM  A 301 ( 3.7A)
None
SAM  A 301 ( 4.9A)
 1.29A 5o4yD-5hg0A:
undetectable
5o4yE-5hg0A:
undetectable		 5o4yD-5hg0A:
4.39
5o4yE-5hg0A:
19.59