SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hgc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 5hgc SERPIN
(Taeniopygia
guttata) 		5 / 12 VAL A  46
PHE A  66
LEU A  69
ASN A 306
PHE A 317
 None
 1.17A 1nw3A-5hgcA:
undetectable		 1nw3A-5hgcA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5hgc SERPIN
(Taeniopygia
guttata) 		4 / 6 LEU A 104
VAL A 338
VAL A 193
ILE A  62
 None
 1.16A 2hyyB-5hgcA:
undetectable		 2hyyB-5hgcA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 5hgc SERPIN
(Taeniopygia
guttata) 		5 / 9 GLY A 325
LEU A 332
THR A 327
LEU A 189
LEU A 136
 None
 1.18A 2npnA-5hgcA:
undetectable		 2npnA-5hgcA:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5hgc SERPIN
(Taeniopygia
guttata) 		5 / 12 PRO A  33
THR A 254
PHE A 256
ILE A 277
PHE A 380
 HCY  A 501 (-3.8A)
HCY  A 501 ( 4.1A)
HCY  A 501 (-4.8A)
HCY  A 501 ( 4.2A)
HCY  A 501 (-4.2A)
 0.54A 2v95A-5hgcA:
43.9		 2v95A-5hgcA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5hgc SERPIN
(Taeniopygia
guttata) 		5 / 12 THR A 254
PHE A 256
ILE A 277
SER A 281
PHE A 380
 HCY  A 501 ( 4.1A)
HCY  A 501 (-4.8A)
HCY  A 501 ( 4.2A)
HCY  A 501 (-3.0A)
HCY  A 501 (-4.2A)
 0.62A 2vdyB-5hgcA:
43.9		 2vdyB-5hgcA:
42.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 5hgc SERPIN
(Taeniopygia
guttata) 		4 / 5 ALA A  86
ALA A  65
TYR A 143
MET A 119
 None
 1.11A 3d91A-5hgcA:
undetectable		 3d91A-5hgcA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5hgc SERPIN
(Taeniopygia
guttata) 		5 / 12 THR A  64
HIS A  98
LEU A 145
ILE A 326
LEU A  82
 None
BDG  A 505 ( 4.6A)
None
None
None
 1.09A 3gwxA-5hgcA:
undetectable		 3gwxA-5hgcA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 5hgc SERPIN
(Taeniopygia
guttata) 		4 / 5 LEU A  89
GLN A  80
LEU A  82
GLU A  83
 None
 1.08A 3h5gA-5hgcA:
undetectable
3h5gB-5hgcA:
undetectable		 3h5gA-5hgcA:
5.38
3h5gB-5hgcA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5hgc SERPIN
(Taeniopygia
guttata) 		4 / 6 LEU A 104
VAL A 338
VAL A 193
ILE A  62
 None
 1.14A 3k5vA-5hgcA:
undetectable		 3k5vA-5hgcA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5hgc SERPIN
(Taeniopygia
guttata) 		4 / 6 LEU A 104
VAL A 338
VAL A 193
ILE A  62
 None
 1.09A 3k5vB-5hgcA:
undetectable		 3k5vB-5hgcA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 5hgc SERPIN
(Taeniopygia
guttata) 		4 / 7 GLY A 114
PHE A  56
PHE A 195
PHE A 389
 None
 1.15A 3ko0L-5hgcA:
undetectable
3ko0N-5hgcA:
undetectable		 3ko0L-5hgcA:
12.37
3ko0N-5hgcA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 5hgc SERPIN
(Taeniopygia
guttata) 		4 / 7 PHE A 195
PHE A 389
GLY A 114
PHE A  56
 None
 1.13A 3ko0K-5hgcA:
undetectable
3ko0S-5hgcA:
undetectable		 3ko0K-5hgcA:
12.37
3ko0S-5hgcA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 5hgc SERPIN
(Taeniopygia
guttata) 		4 / 6 ALA A  65
ILE A  62
HIS A 339
VAL A 193
 None
 1.01A 3nneG-5hgcA:
undetectable		 3nneG-5hgcA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 5hgc SERPIN
(Taeniopygia
guttata) 		5 / 9 VAL A 394
PHE A  43
ASN A  54
ILE A  55
GLY A 391
 None
 1.39A 3t3rB-5hgcA:
undetectable		 3t3rB-5hgcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5hgc SERPIN
(Taeniopygia
guttata) 		5 / 9 VAL A 394
PHE A  43
ASN A  54
ILE A  55
GLY A 391
 None
 1.34A 3t3rC-5hgcA:
undetectable		 3t3rC-5hgcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 5hgc SERPIN
(Taeniopygia
guttata) 		4 / 6 PHE A 101
ASN A  35
PHE A  38
ALA A  39
 None
 0.95A 3t3sB-5hgcA:
undetectable		 3t3sB-5hgcA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 5hgc SERPIN
(Taeniopygia
guttata) 		4 / 8 PHE A 101
ASN A  35
PHE A  38
ALA A  39
 None
 0.86A 3t3sE-5hgcA:
undetectable		 3t3sE-5hgcA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5hgc SERPIN
(Taeniopygia
guttata) 		5 / 12 ILE A 393
VAL A 345
ALA A 341
PHE A  56
ILE A 379
 None
 1.03A 3w67C-5hgcA:
undetectable		 3w67C-5hgcA:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5hgc SERPIN
(Taeniopygia
guttata) 		5 / 11 ALA A  39
THR A 254
PHE A 256
ILE A 277
SER A 281
 None
HCY  A 501 ( 4.1A)
HCY  A 501 (-4.8A)
HCY  A 501 ( 4.2A)
HCY  A 501 (-3.0A)
 1.35A 4bb2A-5hgcA:
36.1
4bb2B-5hgcA:
undetectable		 4bb2A-5hgcA:
38.99
4bb2B-5hgcA:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 5hgc SERPIN
(Taeniopygia
guttata) 		5 / 12 PHE A  42
ILE A  62
LEU A  85
ASN A  35
ALA A  70
 None
 1.05A 4eb4A-5hgcA:
undetectable		 4eb4A-5hgcA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5hgc SERPIN
(Taeniopygia
guttata) 		5 / 12 PHE A  42
ILE A  62
LEU A  85
ASN A  35
ALA A  70
 None
 1.05A 4eb4B-5hgcA:
undetectable		 4eb4B-5hgcA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 5hgc SERPIN
(Taeniopygia
guttata) 		5 / 12 LEU A 272
LEU A 259
CYH A 242
TRP A 280
ASP A 233
 None
 1.38A 4j7xJ-5hgcA:
undetectable		 4j7xJ-5hgcA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 5hgc SERPIN
(Taeniopygia
guttata) 		4 / 8 ILE A  92
LEU A  89
ILE A  97
LEU A  82
 None
 0.75A 4zvcA-5hgcA:
undetectable
4zvcB-5hgcA:
undetectable		 4zvcA-5hgcA:
14.40
4zvcB-5hgcA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 5hgc SERPIN
(Taeniopygia
guttata) 		4 / 8 ILE A  97
LEU A  82
ILE A  92
LEU A  89
 None
 0.76A 4zvcA-5hgcA:
undetectable
4zvcB-5hgcA:
undetectable		 4zvcA-5hgcA:
14.40
4zvcB-5hgcA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5hgc SERPIN
(Taeniopygia
guttata) 		3 / 3 THR A 150
HIS A 339
LEU A 177
 None
 0.77A 5axdA-5hgcA:
undetectable		 5axdA-5hgcA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 5hgc SERPIN
(Taeniopygia
guttata) 		5 / 12 ARG A 246
ILE A 277
ILE A 379
PHE A  40
ILE A 393
 HCY  A 501 (-3.0A)
HCY  A 501 ( 4.2A)
None
None
None
 1.02A 5hw8B-5hgcA:
undetectable
5hw8F-5hgcA:
undetectable
5hw8G-5hgcA:
undetectable		 5hw8B-5hgcA:
17.07
5hw8F-5hgcA:
17.07
5hw8G-5hgcA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5hgc SERPIN
(Taeniopygia
guttata) 		5 / 12 TYR A 143
PHE A 135
ALA A  73
ILE A  62
LEU A 189
 None
 1.24A 6aybA-5hgcA:
undetectable		 6aybA-5hgcA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 5hgc SERPIN
(Taeniopygia
guttata) 		5 / 12 ASN A  35
PHE A  38
PHE A  87
PHE A 101
ILE A 304
 None
 1.27A 6dwnA-5hgcA:
undetectable		 6dwnA-5hgcA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 5hgc SERPIN
(Taeniopygia
guttata) 		5 / 12 ASN A  35
PHE A  38
PHE A  87
PHE A 101
ILE A 304
 None
 1.34A 6dwnB-5hgcA:
undetectable		 6dwnB-5hgcA:
11.32