SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hgq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 5hgq LYSINE--TRNA LIGASE
(Loa
loa) 		4 / 7 LEU A 190
GLY A 194
LEU A 196
TYR A 248
 None
 1.02A 1gtiD-5hgqA:
undetectable		 1gtiD-5hgqA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 5hgq LYSINE--TRNA LIGASE
(Loa
loa) 		4 / 7 LEU A 190
GLY A 194
LEU A 196
TYR A 248
 None
 1.02A 1gtiE-5hgqA:
undetectable		 1gtiE-5hgqA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 5hgq LYSINE--TRNA LIGASE
(Loa
loa) 		4 / 7 ASN A 328
GLY A 397
THR A 416
SER A 411
 None
 1.08A 2o5yH-5hgqA:
undetectable
2o5yL-5hgqA:
undetectable		 2o5yH-5hgqA:
16.83
2o5yL-5hgqA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 5hgq LYSINE--TRNA LIGASE
(Loa
loa) 		3 / 3 ASN A 328
LEU A 395
HIS A 398
 None
 0.63A 2q6fB-5hgqA:
undetectable		 2q6fB-5hgqA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 5hgq LYSINE--TRNA LIGASE
(Loa
loa) 		4 / 5 GLY A 309
PRO A 307
ASN A 495
TYR A 305
 None
 0.93A 3u8qA-5hgqA:
undetectable		 3u8qA-5hgqA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5hgq LYSINE--TRNA LIGASE
(Loa
loa) 		5 / 12 PHE A  40
PRO A 120
LEU A  53
VAL A  51
SER A  46
 None
 1.47A 4a84A-5hgqA:
undetectable		 4a84A-5hgqA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 5hgq LYSINE--TRNA LIGASE
(Loa
loa) 		5 / 12 GLY A  62
ILE A 113
PHE A  31
ILE A 114
ILE A 135
 None
 0.91A 4ax8A-5hgqA:
undetectable		 4ax8A-5hgqA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 5hgq LYSINE--TRNA LIGASE
(Loa
loa) 		4 / 6 GLY A 309
PRO A 307
ASN A 495
TYR A 305
 None
 0.89A 4fjpA-5hgqA:
undetectable		 4fjpA-5hgqA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5hgq LYSINE--TRNA LIGASE
(Loa
loa) 		3 / 3 TYR A 159
PHE A 176
ARG A 162
 None
 1.21A 4g19D-5hgqA:
undetectable		 4g19D-5hgqA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 5hgq LYSINE--TRNA LIGASE
(Loa
loa) 		5 / 12 LEU A 128
GLY A 118
ALA A 121
GLU A 134
PHE A  31
 None
 1.33A 5x6yA-5hgqA:
undetectable		 5x6yA-5hgqA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 5hgq LYSINE--TRNA LIGASE
(Loa
loa) 		7 / 10 ARG A 255
GLU A 257
HIS A 263
PHE A 267
GLU A 427
GLY A 483
ARG A 486
 LYS  A 601 (-3.4A)
KRS  A 602 (-3.1A)
KRS  A 602 (-4.4A)
KRS  A 602 (-3.6A)
KRS  A 602 (-4.3A)
KRS  A 602 (-3.5A)
KRS  A 602 (-3.2A)
 0.80A 6bniA-5hgqA:
43.9		 6bniA-5hgqA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 5hgq LYSINE--TRNA LIGASE
(Loa
loa) 		7 / 10 ARG A 255
HIS A 263
PHE A 267
GLU A 427
GLY A 483
ARG A 486
ILE A 497
 LYS  A 601 (-3.4A)
KRS  A 602 (-4.4A)
KRS  A 602 (-3.6A)
KRS  A 602 (-4.3A)
KRS  A 602 (-3.5A)
KRS  A 602 (-3.2A)
None
 0.38A 6bniA-5hgqA:
43.9		 6bniA-5hgqA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 5hgq LYSINE--TRNA LIGASE
(Loa
loa) 		8 / 10 ARG A 255
GLU A 257
HIS A 263
PHE A 267
GLU A 427
GLY A 483
ARG A 486
ILE A 497
 LYS  A 601 (-3.4A)
KRS  A 602 (-3.1A)
KRS  A 602 (-4.4A)
KRS  A 602 (-3.6A)
KRS  A 602 (-4.3A)
KRS  A 602 (-3.5A)
KRS  A 602 (-3.2A)
None
 0.72A 6bniB-5hgqA:
44.1		 6bniB-5hgqA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 5hgq LYSINE--TRNA LIGASE
(Loa
loa) 		4 / 4 LEU A 142
ASP A 112
PRO A 140
ARG A  12
 None
 1.36A 6fgdA-5hgqA:
undetectable		 6fgdA-5hgqA:
24.86