SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hgz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 5hgz N-ALPHA-ACETYLTRANSF
ERASE 60
(Homo
sapiens) 		5 / 12 PHE A 175
TYR A 177
ASP A  81
ASN A 148
ALA A 146
 None
None
None
None
ACO  A 301 (-3.6A)
 1.25A 2vdmA-5hgzA:
undetectable
2vdmB-5hgzA:
undetectable		 2vdmA-5hgzA:
19.31
2vdmB-5hgzA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5hgz N-ALPHA-ACETYLTRANSF
ERASE 60
(Homo
sapiens) 		4 / 8 HIS A 138
ASP A  81
ILE A  77
VAL A  95
 None
 0.80A 3fi0B-5hgzA:
undetectable		 3fi0B-5hgzA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5hgz N-ALPHA-ACETYLTRANSF
ERASE 60
(Homo
sapiens) 		4 / 7 HIS A 138
ASP A  81
ILE A  77
VAL A  95
 None
 0.85A 3fi0E-5hgzA:
undetectable		 3fi0E-5hgzA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 5hgz N-ALPHA-ACETYLTRANSF
ERASE 60
(Homo
sapiens) 		5 / 12 VAL A  91
ILE A  77
LYS A  79
VAL A  95
ILE A  71
 None
 1.44A 4eb6B-5hgzA:
undetectable
4eb6C-5hgzA:
undetectable		 4eb6B-5hgzA:
17.97
4eb6C-5hgzA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 5hgz N-ALPHA-ACETYLTRANSF
ERASE 60
(Homo
sapiens) 		5 / 12 ALA A  56
THR A  58
LEU A  18
THR A  25
GLY A 102
 None
None
None
None
ACO  A 301 (-3.4A)
 1.02A 4ypmA-5hgzA:
undetectable		 4ypmA-5hgzA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5hgz N-ALPHA-ACETYLTRANSF
ERASE 60
(Homo
sapiens) 		4 / 7 ASN A  49
LYS A  50
LYS A  51
LEU A 120
 None
 1.24A 4yv5A-5hgzA:
undetectable		 4yv5A-5hgzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5hgz N-ALPHA-ACETYLTRANSF
ERASE 60
(Homo
sapiens) 		5 / 12 LEU A 101
LEU A  99
LEU A 120
ALA A  96
ILE A 135
 ACO  A 301 (-4.3A)
None
None
None
None
 1.06A 5mioB-5hgzA:
undetectable		 5mioB-5hgzA:
17.97