SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hha'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_F_BEZF511_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5hha PVDO
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 147
PHE A  31
ARG A 282
ALA A  76
 None
 1.24A 1oniE-5hhaA:
undetectable
1oniF-5hhaA:
undetectable		 1oniE-5hhaA:
20.00
1oniF-5hhaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5hha PVDO
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 213
ALA A 183
SER A 259
TYR A 177
PHE A 169
 None
 1.29A 1y7iA-5hhaA:
undetectable		 1y7iA-5hhaA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 5hha PVDO
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 187
SER A 189
ASP A 210
ASN A 214
GLY A 191
 CA  A 301 (-4.3A)
None
None
None
None
 1.40A 2hmaA-5hhaA:
undetectable		 2hmaA-5hhaA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_1
(16S RRNA METHYLASE)		 5hha PVDO
(Pseudomonas
aeruginosa) 		4 / 4 ASN A 250
ASP A 210
GLU A  86
TRP A 252
 None
 1.33A 3mteA-5hhaA:
0.0		 3mteA-5hhaA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5hha PVDO
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 264
GLU A 152
GLY A 262
ARG A 160
HIS A 224
 None
 1.00A 4ffwA-5hhaA:
undetectable		 4ffwA-5hhaA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5hha PVDO
(Pseudomonas
aeruginosa) 		4 / 7 PRO A 231
SER A 235
MET A 238
TRP A 237
 None
 1.36A 4kmmA-5hhaA:
undetectable		 4kmmA-5hhaA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJJ_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 5hha PVDO
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 152
ASP A  62
GLU A  56
GLU A 156
GLN A 246
 None
 1.42A 4njjB-5hhaA:
undetectable		 4njjB-5hhaA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hha PVDO
(Pseudomonas
aeruginosa) 		4 / 5 ALA A 161
TYR A 157
PRO A  27
PHE A  75
 None
 1.11A 4ze2A-5hhaA:
undetectable		 4ze2A-5hhaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 5hha PVDO
(Pseudomonas
aeruginosa) 		4 / 5 PRO A 123
VAL A 215
GLY A 101
VAL A 127
 None
 1.00A 6ak3B-5hhaA:
undetectable		 6ak3B-5hhaA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 5hha PVDO
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 162
ALA A 161
VAL A  41
LEU A  43
 None
 0.81A 6dwnB-5hhaA:
undetectable		 6dwnB-5hhaA:
13.43