SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hhl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE
([Eubacterium]
rectale) 		5 / 12 ILE A 140
ILE A 245
ILE A 181
ALA A 203
ASN A 204
 None
 1.14A 1jtxA-5hhlA:
1.0		 1jtxA-5hhlA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE
([Eubacterium]
rectale) 		5 / 12 VAL A  82
ASN A  26
GLY A  28
ALA A  29
LEU A  80
 None
 1.09A 1r9oA-5hhlA:
undetectable		 1r9oA-5hhlA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE
([Eubacterium]
rectale) 		4 / 8 TYR A 102
PHE A 106
ALA A  95
LEU A 202
 None
 1.04A 1x8vA-5hhlA:
undetectable		 1x8vA-5hhlA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE
([Eubacterium]
rectale) 		3 / 3 ASN A 239
ILE A 140
MET A 259
 None
 0.81A 2h42C-5hhlA:
undetectable		 2h42C-5hhlA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE
([Eubacterium]
rectale) 		4 / 8 ARG A  66
ASP A  33
ARG A  88
ALA A  29
 None
 1.26A 2rk8A-5hhlA:
undetectable		 2rk8A-5hhlA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE
([Eubacterium]
rectale) 		5 / 12 ASP A 227
GLU A 186
LEU A 270
GLY A 276
HIS A 291
 K  A 301 (-3.7A)
None
None
None
None
 1.11A 2zj0B-5hhlA:
undetectable		 2zj0B-5hhlA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE
([Eubacterium]
rectale) 		5 / 12 ASP A 227
GLU A 186
LEU A 270
GLY A 276
HIS A 291
 K  A 301 (-3.7A)
None
None
None
None
 1.21A 2zj0C-5hhlA:
undetectable		 2zj0C-5hhlA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE
([Eubacterium]
rectale) 		5 / 12 ASP A 227
GLU A 186
LEU A 270
GLY A 276
HIS A 291
 K  A 301 (-3.7A)
None
None
None
None
 1.17A 3ce6B-5hhlA:
undetectable		 3ce6B-5hhlA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE
([Eubacterium]
rectale) 		5 / 9 LEU A 198
VAL A 167
ILE A  90
LEU A  55
ILE A  10
 None
 1.18A 3jw3B-5hhlA:
undetectable		 3jw3B-5hhlA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE
([Eubacterium]
rectale) 		5 / 12 ILE A  90
GLY A  48
THR A  86
LEU A  40
GLY A  53
 None
 0.93A 3uq6B-5hhlA:
undetectable		 3uq6B-5hhlA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE
([Eubacterium]
rectale) 		5 / 12 ILE A  90
GLY A  48
THR A  86
LEU A  40
GLY A  53
 None
 1.04A 3vaqB-5hhlA:
undetectable		 3vaqB-5hhlA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE
([Eubacterium]
rectale) 		4 / 8 GLU A 209
GLU A 213
LYS A 216
ARG A 217
 None
 0.93A 4bqfB-5hhlA:
undetectable		 4bqfB-5hhlA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE
([Eubacterium]
rectale) 		3 / 3 PHE A 106
ASP A 108
ARG A 117
 None
 0.75A 4eahF-5hhlA:
undetectable		 4eahF-5hhlA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE
([Eubacterium]
rectale) 		3 / 3 PHE A 106
ASP A 108
ARG A 117
 None
 0.75A 4eahG-5hhlA:
undetectable		 4eahG-5hhlA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE
([Eubacterium]
rectale) 		4 / 4 LYS A 212
LEU A 210
GLU A 209
LEU A 253
 None
 1.43A 4k4yE-5hhlA:
12.3		 4k4yE-5hhlA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE
([Eubacterium]
rectale) 		4 / 6 TYR A 102
VAL A 167
ILE A 168
LEU A 154
 None
 0.79A 4l1wB-5hhlA:
undetectable		 4l1wB-5hhlA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE
([Eubacterium]
rectale) 		5 / 12 ILE A  10
ILE A 168
ARG A 172
LEU A 202
LEU A 198
 None
 1.03A 4m2xC-5hhlA:
undetectable		 4m2xC-5hhlA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE
([Eubacterium]
rectale) 		3 / 3 MET A  35
GLU A  39
LEU A  40
 None
 0.80A 4v2oB-5hhlA:
2.0		 4v2oB-5hhlA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE
([Eubacterium]
rectale) 		4 / 4 LEU A  80
TYR A 174
PRO A 200
ILE A 181
 None
 1.04A 5esgA-5hhlA:
undetectable		 5esgA-5hhlA:
20.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HHJ_B_GLYB404_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE
([Eubacterium]
rectale) 		4 / 4 GLN A  92
ALA A  95
GLN A  96
THR A  99
 None
 0.17A 5hhjB-5hhlA:
45.7		 5hhjB-5hhlA:
94.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE
([Eubacterium]
rectale) 		5 / 11 GLY A 178
GLY A 195
GLN A  91
THR A  86
THR A  84
 None
 1.50A 5x1bG-5hhlA:
undetectable
5x1bN-5hhlA:
0.3
5x1bO-5hhlA:
undetectable		 5x1bG-5hhlA:
15.17
5x1bN-5hhlA:
19.66
5x1bO-5hhlA:
22.55