SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hif'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		4 / 4 HIS A 200
LEU A  39
LEU A  34
LEU A  90
 ZN  A 402 (-3.4A)
None
PEG  A 403 ( 4.8A)
None
 1.15A 1a4lD-5hifA:
undetectable		 1a4lD-5hifA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		5 / 12 LEU A 147
GLY A 165
ALA A 168
GLY A 122
LEU A 123
 None
 1.13A 1fe2A-5hifA:
undetectable		 1fe2A-5hifA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		5 / 12 LEU A 147
GLY A 165
ALA A 168
GLY A 122
LEU A 123
 None
 1.10A 1igxA-5hifA:
undetectable		 1igxA-5hifA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		5 / 12 LEU A 269
GLY A 220
ILE A 223
HIS A 204
HIS A 114
 None
None
None
None
ZN  A 402 (-3.4A)
 1.30A 1tmxB-5hifA:
undetectable		 1tmxB-5hifA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		5 / 11 LEU A  77
ILE A 110
HIS A 114
ASP A 221
GLY A 220
 None
None
ZN  A 402 (-3.4A)
ZN  A 401 ( 2.4A)
None
 0.96A 1zz1A-5hifA:
undetectable		 1zz1A-5hifA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		5 / 12 LEU A  77
ILE A 110
HIS A 114
ASP A 221
GLY A 220
 None
None
ZN  A 402 (-3.4A)
ZN  A 401 ( 2.4A)
None
 0.96A 1zz1C-5hifA:
undetectable		 1zz1C-5hifA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_E_CUE801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		4 / 4 LEU A 222
HIS A 114
HIS A 204
HIS A 200
 None
ZN  A 402 (-3.4A)
None
ZN  A 402 (-3.4A)
 0.88A 2oqeE-5hifA:
undetectable		 2oqeE-5hifA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		4 / 8 ASP A 118
LEU A  34
HIS A 268
LEU A  90
 ZN  A 401 ( 2.5A)
PEG  A 403 ( 4.8A)
ZN  A 401 ( 3.2A)
None
 1.07A 2q0iA-5hifA:
15.2		 2q0iA-5hifA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		5 / 11 ASP A 118
HIS A 119
HIS A 200
ASP A 221
HIS A 268
 ZN  A 401 ( 2.5A)
ZN  A 401 (-3.3A)
ZN  A 402 (-3.4A)
ZN  A 401 ( 2.4A)
ZN  A 401 ( 3.2A)
 0.57A 2q0jB-5hifA:
15.1		 2q0jB-5hifA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		4 / 6 ASP A 221
ILE A 223
LEU A 269
TYR A  67
 ZN  A 401 ( 2.4A)
None
None
None
 1.06A 2ya7A-5hifA:
undetectable		 2ya7A-5hifA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		4 / 6 ASP A 221
ILE A 223
LEU A 269
TYR A  67
 ZN  A 401 ( 2.4A)
None
None
None
 1.04A 2ya7D-5hifA:
undetectable		 2ya7D-5hifA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		4 / 5 HIS A 200
HIS A 224
HIS A 268
ASP A 118
 ZN  A 402 (-3.4A)
None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 2.5A)
 1.22A 3c0zA-5hifA:
undetectable		 3c0zA-5hifA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		5 / 12 HIS A 204
THR A 201
ASP A  79
LEU A 222
HIS A 119
 None
None
None
None
ZN  A 401 (-3.3A)
 1.33A 3n58C-5hifA:
undetectable		 3n58C-5hifA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		5 / 9 LEU A 216
ALA A 257
ASP A 256
ILE A 223
LEU A 218
 None
 1.06A 3u7sA-5hifA:
undetectable		 3u7sA-5hifA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		5 / 10 HIS A 114
HIS A 116
ASP A 118
HIS A 200
HIS A 268
 ZN  A 402 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 ( 2.5A)
ZN  A 402 (-3.4A)
ZN  A 401 ( 3.2A)
 0.69A 4c1dB-5hifA:
16.1		 4c1dB-5hifA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		5 / 11 HIS A 114
HIS A 116
ASP A 118
HIS A 200
HIS A 268
 ZN  A 402 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 ( 2.5A)
ZN  A 402 (-3.4A)
ZN  A 401 ( 3.2A)
 0.71A 4c1fA-5hifA:
17.0
4c1fB-5hifA:
16.9		 4c1fA-5hifA:
25.27
4c1fB-5hifA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		5 / 9 HIS A 114
HIS A 116
ASP A 118
HIS A 200
HIS A 268
 ZN  A 402 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 ( 2.5A)
ZN  A 402 (-3.4A)
ZN  A 401 ( 3.2A)
 0.68A 4c1hA-5hifA:
16.0		 4c1hA-5hifA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		5 / 10 GLY A 121
ASP A 118
GLY A  81
HIS A 114
HIS A 268
 None
ZN  A 401 ( 2.5A)
None
ZN  A 402 (-3.4A)
ZN  A 401 ( 3.2A)
 1.05A 4c5nB-5hifA:
undetectable		 4c5nB-5hifA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		5 / 8 VAL A  32
HIS A 116
ASP A 118
HIS A 200
HIS A 268
 None
ZN  A 402 (-3.2A)
ZN  A 401 ( 2.5A)
ZN  A 402 (-3.4A)
ZN  A 401 ( 3.2A)
 0.96A 4exsB-5hifA:
15.4		 4exsB-5hifA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		4 / 6 PHE A 179
ILE A 112
TYR A 207
PHE A 182
 None
 1.47A 4o7gB-5hifA:
undetectable		 4o7gB-5hifA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		4 / 6 PHE A 239
ASP A 221
HIS A 268
THR A  62
 PEG  A 403 ( 3.8A)
ZN  A 401 ( 2.4A)
ZN  A 401 ( 3.2A)
None
 1.31A 4paeA-5hifA:
undetectable		 4paeA-5hifA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_1
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		4 / 6 ASN A 185
LEU A 195
GLU A 249
LYS A 252
 None
 1.46A 4wcxC-5hifA:
undetectable		 4wcxC-5hifA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		4 / 8 HIS A 116
ASP A 118
HIS A 200
HIS A 268
 ZN  A 402 (-3.2A)
ZN  A 401 ( 2.5A)
ZN  A 402 (-3.4A)
ZN  A 401 ( 3.2A)
 0.73A 5a5zA-5hifA:
15.8		 5a5zA-5hifA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		6 / 11 HIS A 114
HIS A 116
ASP A 118
HIS A 119
HIS A 200
HIS A 268
 ZN  A 402 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 ( 2.5A)
ZN  A 401 (-3.3A)
ZN  A 402 (-3.4A)
ZN  A 401 ( 3.2A)
 0.39A 5ayaA-5hifA:
16.1		 5ayaA-5hifA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		4 / 4 ASP A 221
HIS A 114
HIS A 116
HIS A 224
 ZN  A 401 ( 2.4A)
ZN  A 402 (-3.4A)
ZN  A 402 (-3.2A)
None
 1.47A 5ncdD-5hifA:
undetectable		 5ncdD-5hifA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		4 / 8 ASP A 221
HIS A 200
HIS A 114
HIS A 268
 ZN  A 401 ( 2.4A)
ZN  A 402 (-3.4A)
ZN  A 402 (-3.4A)
ZN  A 401 ( 3.2A)
 0.93A 5nekD-5hifA:
undetectable		 5nekD-5hifA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		6 / 10 HIS A 114
HIS A 116
HIS A 119
HIS A 200
ASP A 221
HIS A 224
 ZN  A 402 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 402 (-3.4A)
ZN  A 401 ( 2.4A)
None
 0.50A 5nzwA-5hifA:
5.5		 5nzwA-5hifA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		5 / 10 HIS A 200
HIS A 114
HIS A 224
ASP A 221
HIS A 268
 ZN  A 402 (-3.4A)
ZN  A 402 (-3.4A)
None
ZN  A 401 ( 2.4A)
ZN  A 401 ( 3.2A)
 0.95A 5nzwA-5hifA:
5.5		 5nzwA-5hifA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		3 / 3 HIS A 119
ASP A 221
HIS A 268
 ZN  A 401 (-3.3A)
ZN  A 401 ( 2.4A)
ZN  A 401 ( 3.2A)
 0.80A 5oexA-5hifA:
undetectable		 5oexA-5hifA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		3 / 3 HIS A 119
ASP A 221
HIS A 268
 ZN  A 401 (-3.3A)
ZN  A 401 ( 2.4A)
ZN  A 401 ( 3.2A)
 0.78A 5oexC-5hifA:
undetectable		 5oexC-5hifA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		4 / 8 HIS A 116
ASP A 118
HIS A 200
HIS A 268
 ZN  A 402 (-3.2A)
ZN  A 401 ( 2.5A)
ZN  A 402 (-3.4A)
ZN  A 401 ( 3.2A)
 0.71A 5zj8A-5hifA:
15.9		 5zj8A-5hifA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_1
(-)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		5 / 12 HIS A 204
THR A 201
ASP A  79
LEU A 222
HIS A 119
 None
None
None
None
ZN  A 401 (-3.3A)
 1.39A 6gbnC-5hifA:
undetectable		 6gbnC-5hifA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH
(synthetic
construct) 		5 / 11 SER A 169
GLY A  91
GLY A  81
ASP A  29
VAL A  64
 None
 1.18A 6i5zD-5hifA:
undetectable		 6i5zD-5hifA:
22.75