SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hiu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A600_1
(ORF12)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
5 / 11 SER A 384
ALA A 382
GLY A 381
SER A 323
PHE A 359
SER  A 384 ( 0.0A)
ALA  A 382 ( 0.0A)
GLY  A 381 ( 0.0A)
SER  A 323 ( 0.0A)
PHE  A 359 ( 1.3A)
1.37A 2xf3A-5hiuA:
undetectable
2xf3A-5hiuA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B600_1
(ORF12)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
5 / 11 SER A 384
ALA A 382
GLY A 381
SER A 323
PHE A 359
SER  A 384 ( 0.0A)
ALA  A 382 ( 0.0A)
GLY  A 381 ( 0.0A)
SER  A 323 ( 0.0A)
PHE  A 359 ( 1.3A)
1.36A 2xf3B-5hiuA:
undetectable
2xf3B-5hiuA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
3 / 3 ASN A 366
ASP A 378
GLN A 320
ASN  A 366 ( 0.6A)
ASP  A 378 ( 0.6A)
GLN  A 320 ( 0.6A)
0.84A 3eeyC-5hiuA:
undetectable
3eeyC-5hiuA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
3 / 3 ASN A 366
ASP A 378
GLN A 320
ASN  A 366 ( 0.6A)
ASP  A 378 ( 0.6A)
GLN  A 320 ( 0.6A)
0.82A 3eeyE-5hiuA:
undetectable
3eeyE-5hiuA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
3 / 3 PHE A 359
SER A 324
GLN A 320
PHE  A 359 ( 1.3A)
SER  A 324 ( 0.0A)
GLN  A 320 ( 0.6A)
0.85A 3smtA-5hiuA:
undetectable
3smtA-5hiuA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
5 / 12 LEU A 432
PRO A 442
ALA A 394
LEU A 405
GLY A 409
LEU  A 432 ( 0.6A)
PRO  A 442 ( 1.1A)
ALA  A 394 ( 0.0A)
LEU  A 405 ( 0.5A)
GLY  A 409 ( 0.0A)
1.23A 4l9qB-5hiuA:
undetectable
4l9qB-5hiuA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
5 / 12 LEU A 251
LEU A 254
LEU A 257
ALA A 256
LEU A 281
LEU  A 251 ( 0.5A)
LEU  A 254 ( 0.6A)
LEU  A 257 ( 0.6A)
ALA  A 256 ( 0.0A)
LEU  A 281 ( 0.6A)
1.19A 4ltwA-5hiuA:
undetectable
4ltwA-5hiuA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
5 / 10 LEU A 432
LEU A 428
LEU A 383
ILE A 443
VAL A 353
LEU  A 432 ( 0.6A)
LEU  A 428 ( 0.5A)
LEU  A 383 ( 0.5A)
ILE  A 443 ( 0.7A)
VAL  A 353 ( 0.6A)
1.19A 4mk4A-5hiuA:
undetectable
4mk4A-5hiuA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
5 / 12 LEU A 212
LEU A 173
GLN A 185
THR A 193
PHE A 170
LEU  A 212 ( 0.6A)
LEU  A 173 ( 0.5A)
GLN  A 185 ( 0.6A)
THR  A 193 ( 0.8A)
PHE  A 170 ( 1.3A)
1.22A 4wnwA-5hiuA:
undetectable
4wnwA-5hiuA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
5 / 8 ILE A 429
LEU A 432
LEU A 410
ILE A 452
LEU A 444
ILE  A 429 ( 0.7A)
LEU  A 432 ( 0.6A)
LEU  A 410 ( 0.6A)
ILE  A 452 ( 0.7A)
LEU  A 444 ( 0.6A)
1.49A 4zvcA-5hiuA:
undetectable
4zvcB-5hiuA:
2.1
4zvcA-5hiuA:
13.09
4zvcB-5hiuA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
5 / 8 ILE A 452
LEU A 444
ILE A 429
LEU A 432
LEU A 410
ILE  A 452 ( 0.7A)
LEU  A 444 ( 0.6A)
ILE  A 429 ( 0.7A)
LEU  A 432 ( 0.6A)
LEU  A 410 ( 0.6A)
1.49A 4zvcA-5hiuA:
undetectable
4zvcB-5hiuA:
2.1
4zvcA-5hiuA:
13.09
4zvcB-5hiuA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
5 / 9 ILE A 153
THR A 193
GLN A 146
LEU A 186
LEU A 257
ILE  A 153 ( 0.6A)
THR  A 193 ( 0.8A)
GLN  A 146 ( 0.6A)
LEU  A 186 ( 0.5A)
LEU  A 257 ( 0.6A)
1.37A 5fhzB-5hiuA:
undetectable
5fhzB-5hiuA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
3 / 3 TRP A 129
ILE A 136
SER A 148
TRP  A 129 ( 0.5A)
ILE  A 136 ( 0.6A)
SER  A 148 ( 0.0A)
0.91A 5gqbA-5hiuA:
undetectable
5gqbA-5hiuA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
4 / 6 LEU A 251
SER A 252
PHE A 255
HIS A 299
LEU  A 251 ( 0.5A)
SER  A 252 ( 0.0A)
PHE  A 255 ( 1.3A)
HIS  A 299 ( 1.0A)
1.09A 5om3A-5hiuA:
undetectable
5om3B-5hiuA:
undetectable
5om3A-5hiuA:
11.93
5om3B-5hiuA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
4 / 8 ALA A 457
ILE A 425
ALA A 422
LEU A 426
ALA  A 457 ( 0.0A)
ILE  A 425 ( 0.7A)
ALA  A 422 ( 0.0A)
LEU  A 426 ( 0.6A)
0.78A 5te8B-5hiuA:
undetectable
5te8B-5hiuA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
5 / 10 PHE A 207
LEU A 210
THR A 211
GLY A 276
ILE A 274
PHE  A 207 ( 1.3A)
LEU  A 210 ( 0.5A)
THR  A 211 ( 0.8A)
GLY  A 276 ( 0.0A)
ILE  A 274 ( 0.7A)
0.87A 6ebpB-5hiuA:
undetectable
6ebpB-5hiuA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
5 / 10 PHE A 207
LEU A 210
THR A 211
GLY A 276
ILE A 274
PHE  A 207 ( 1.3A)
LEU  A 210 ( 0.5A)
THR  A 211 ( 0.8A)
GLY  A 276 ( 0.0A)
ILE  A 274 ( 0.7A)
0.89A 6ebpC-5hiuA:
undetectable
6ebpC-5hiuA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
6 / 10 PHE A 207
LEU A 210
THR A 211
GLY A 276
ILE A 274
ILE A 262
PHE  A 207 ( 1.3A)
LEU  A 210 ( 0.5A)
THR  A 211 ( 0.8A)
GLY  A 276 ( 0.0A)
ILE  A 274 ( 0.7A)
ILE  A 262 ( 0.7A)
0.97A 6ebpD-5hiuA:
undetectable
6ebpD-5hiuA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
6 / 11 PHE A 207
LEU A 210
THR A 211
GLY A 276
ILE A 274
ILE A 262
PHE  A 207 ( 1.3A)
LEU  A 210 ( 0.5A)
THR  A 211 ( 0.8A)
GLY  A 276 ( 0.0A)
ILE  A 274 ( 0.7A)
ILE  A 262 ( 0.7A)
0.98A 6ebzA-5hiuA:
undetectable
6ebzA-5hiuA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
6 / 11 PHE A 207
LEU A 210
THR A 211
GLY A 276
ILE A 274
ILE A 262
PHE  A 207 ( 1.3A)
LEU  A 210 ( 0.5A)
THR  A 211 ( 0.8A)
GLY  A 276 ( 0.0A)
ILE  A 274 ( 0.7A)
ILE  A 262 ( 0.7A)
1.01A 6ebzB-5hiuA:
undetectable
6ebzB-5hiuA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
6 / 11 PHE A 207
LEU A 210
THR A 211
GLY A 276
ILE A 274
ILE A 262
PHE  A 207 ( 1.3A)
LEU  A 210 ( 0.5A)
THR  A 211 ( 0.8A)
GLY  A 276 ( 0.0A)
ILE  A 274 ( 0.7A)
ILE  A 262 ( 0.7A)
1.04A 6ebzC-5hiuA:
undetectable
6ebzC-5hiuA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
6 / 11 PHE A 207
LEU A 210
THR A 211
GLY A 276
ILE A 274
ILE A 262
PHE  A 207 ( 1.3A)
LEU  A 210 ( 0.5A)
THR  A 211 ( 0.8A)
GLY  A 276 ( 0.0A)
ILE  A 274 ( 0.7A)
ILE  A 262 ( 0.7A)
0.99A 6ebzD-5hiuA:
undetectable
6ebzD-5hiuA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
6 / 11 PHE A 207
LEU A 210
THR A 211
GLY A 276
ILE A 274
ILE A 262
PHE  A 207 ( 1.3A)
LEU  A 210 ( 0.5A)
THR  A 211 ( 0.8A)
GLY  A 276 ( 0.0A)
ILE  A 274 ( 0.7A)
ILE  A 262 ( 0.7A)
0.95A 6gp2A-5hiuA:
undetectable
6gp2A-5hiuA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum)
6 / 11 PHE A 207
LEU A 210
THR A 211
GLY A 276
ILE A 274
ILE A 262
PHE  A 207 ( 1.3A)
LEU  A 210 ( 0.5A)
THR  A 211 ( 0.8A)
GLY  A 276 ( 0.0A)
ILE  A 274 ( 0.7A)
ILE  A 262 ( 0.7A)
0.86A 6gp2B-5hiuA:
undetectable
6gp2B-5hiuA:
10.80