SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hiw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 5hiw CYTOCHROME P450
CYP260B1
(Sorangium
cellulosum) 		4 / 4 ARG A 205
ALA A 209
ALA A  89
GLU A 202
 None
 1.24A 1e7bB-5hiwA:
undetectable		 1e7bB-5hiwA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 5hiw CYTOCHROME P450
CYP260B1
(Sorangium
cellulosum) 		4 / 7 LEU A 142
MET A 180
LEU A 223
MET A 157
 None
 1.15A 1linA-5hiwA:
undetectable		 1linA-5hiwA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5hiw CYTOCHROME P450
CYP260B1
(Sorangium
cellulosum) 		5 / 10 ALA A 276
SER A 302
TYR A  32
PHE A  18
LEU A  37
 None
 1.33A 1y7iB-5hiwA:
undetectable		 1y7iB-5hiwA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 5hiw CYTOCHROME P450
CYP260B1
(Sorangium
cellulosum) 		5 / 11 LEU A 362
LEU A 356
ILE A 387
PRO A 384
ASN A 239
 None
 1.13A 2ft9A-5hiwA:
undetectable		 2ft9A-5hiwA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5hiw CYTOCHROME P450
CYP260B1
(Sorangium
cellulosum) 		4 / 8 SER A 137
ILE A 147
ASP A 151
ARG A 155
 None
 1.06A 2v57A-5hiwA:
undetectable		 2v57A-5hiwA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5hiw CYTOCHROME P450
CYP260B1
(Sorangium
cellulosum) 		4 / 8 SER A 137
ILE A 147
ASP A 151
ARG A 155
 None
 1.06A 2v57C-5hiwA:
undetectable		 2v57C-5hiwA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 5hiw CYTOCHROME P450
CYP260B1
(Sorangium
cellulosum) 		4 / 6 ARG A 315
ASP A 320
ILE A 321
GLN A 257
 None
 1.31A 2ya7C-5hiwA:
undetectable		 2ya7C-5hiwA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 5hiw CYTOCHROME P450
CYP260B1
(Sorangium
cellulosum) 		4 / 4 LEU A 223
ARG A 146
LEU A 142
ALA A 182
 None
 0.94A 3b9mA-5hiwA:
undetectable		 3b9mA-5hiwA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 5hiw CYTOCHROME P450
CYP260B1
(Sorangium
cellulosum) 		5 / 12 THR A 232
VAL A  73
THR A  62
ILE A 278
THR A  60
 HEM  A 401 (-3.7A)
HEM  A 401 (-3.6A)
None
HEM  A 401 (-3.5A)
None
 1.30A 3dl9B-5hiwA:
29.3		 3dl9B-5hiwA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 5hiw CYTOCHROME P450
CYP260B1
(Sorangium
cellulosum) 		5 / 10 ALA A 344
ILE A 203
LEU A  91
THR A 233
ILE A 154
 HEM  A 401 (-3.5A)
None
None
HEM  A 401 (-4.5A)
None
 1.19A 3prsA-5hiwA:
undetectable		 3prsA-5hiwA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5hiw CYTOCHROME P450
CYP260B1
(Sorangium
cellulosum) 		5 / 10 LEU A 237
LEU A 244
LEU A 356
LEU A 355
PHE A 127
 None
 0.71A 4odoA-5hiwA:
undetectable		 4odoA-5hiwA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5hiw CYTOCHROME P450
CYP260B1
(Sorangium
cellulosum) 		5 / 10 LEU A 237
LEU A 244
LEU A 356
LEU A 355
PHE A 127
 None
 0.75A 4odoB-5hiwA:
undetectable		 4odoB-5hiwA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5hiw CYTOCHROME P450
CYP260B1
(Sorangium
cellulosum) 		5 / 10 LEU A 237
LEU A 244
LEU A 356
LEU A 355
PHE A 127
 None
 0.75A 4odoC-5hiwA:
undetectable		 4odoC-5hiwA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5hiw CYTOCHROME P450
CYP260B1
(Sorangium
cellulosum) 		5 / 12 LEU A 237
LEU A 244
LEU A 356
LEU A 355
PHE A 127
 None
 0.93A 4odrA-5hiwA:
undetectable
4odrB-5hiwA:
undetectable		 4odrA-5hiwA:
15.33
4odrB-5hiwA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5hiw CYTOCHROME P450
CYP260B1
(Sorangium
cellulosum) 		5 / 11 LEU A 237
LEU A 244
LEU A 356
LEU A 355
PHE A 127
 None
 0.81A 4odrA-5hiwA:
undetectable
4odrB-5hiwA:
undetectable		 4odrA-5hiwA:
15.33
4odrB-5hiwA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 5hiw CYTOCHROME P450
CYP260B1
(Sorangium
cellulosum) 		5 / 12 ILE A 298
THR A 232
ALA A 275
ALA A 276
TYR A  63
 None
HEM  A 401 (-3.7A)
HEM  A 401 ( 4.1A)
None
HEM  A 401 (-4.4A)
 1.45A 4u14A-5hiwA:
undetectable		 4u14A-5hiwA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 5hiw CYTOCHROME P450
CYP260B1
(Sorangium
cellulosum) 		4 / 5 LEU A 244
THR A 269
PRO A 384
ARG A 377
 None
 1.29A 6ew0B-5hiwA:
undetectable		 6ew0B-5hiwA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 5hiw CYTOCHROME P450
CYP260B1
(Sorangium
cellulosum) 		4 / 5 LEU A 244
THR A 269
PRO A 384
ARG A 377
 None
 1.29A 6ew0D-5hiwA:
undetectable		 6ew0D-5hiwA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 5hiw CYTOCHROME P450
CYP260B1
(Sorangium
cellulosum) 		4 / 5 LEU A 244
THR A 269
PRO A 384
ARG A 377
 None
 1.29A 6ew0H-5hiwA:
undetectable		 6ew0H-5hiwA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 5hiw CYTOCHROME P450
CYP260B1
(Sorangium
cellulosum) 		4 / 5 LEU A 244
THR A 269
PRO A 384
ARG A 377
 None
 1.29A 6ew0I-5hiwA:
undetectable		 6ew0I-5hiwA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5hiw CYTOCHROME P450
CYP260B1
(Sorangium
cellulosum) 		5 / 10 ALA A 121
LEU A 241
LEU A 245
LEU A 356
LEU A 355
 None
 0.97A 6f6nA-5hiwA:
undetectable
6f6nB-5hiwA:
undetectable		 6f6nA-5hiwA:
10.78
6f6nB-5hiwA:
11.68