SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hj2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 5hj2 INTEGRIN ALPHA-2
(Homo
sapiens) 		4 / 7 SER C 121
THR C  87
ASN C  86
TYR C  51
 None
 0.95A 1dssG-5hj2C:
2.8		 1dssG-5hj2C:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 5hj2 INTEGRIN ALPHA-2
(Homo
sapiens) 		4 / 8 SER C 121
THR C  87
ASN C  86
TYR C  51
 None
 0.94A 1dssR-5hj2C:
2.6		 1dssR-5hj2C:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5hj2 INTEGRIN ALPHA-2
(Homo
sapiens) 		5 / 12 ALA C 189
GLY C 190
LEU C 185
THR C  77
LEU C  48
 None
 0.96A 2nyuB-5hj2C:
undetectable		 2nyuB-5hj2C:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 5hj2 INTEGRIN ALPHA-2
(Homo
sapiens) 		4 / 8 SER C 121
THR C  87
ASN C  86
TYR C  51
 None
 0.89A 3dmtC-5hj2C:
4.4		 3dmtC-5hj2C:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 5hj2 INTEGRIN ALPHA-2
(Homo
sapiens) 		5 / 9 ASP C  15
GLY C 148
LEU C 147
VAL C  26
ILE C  20
 CA  C 301 ( 4.5A)
None
None
None
None
 1.20A 3em4B-5hj2C:
undetectable		 3em4B-5hj2C:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 5hj2 INTEGRIN ALPHA-2
(Homo
sapiens) 		3 / 3 ASP C 118
ASP C  15
ASN C  86
 CA  C 301 (-3.4A)
CA  C 301 ( 4.5A)
None
 0.74A 4q5mA-5hj2C:
undetectable		 4q5mA-5hj2C:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 5hj2 INTEGRIN ALPHA-2
(Homo
sapiens) 		5 / 12 GLY C  40
LYS C  43
LYS C  32
GLY C 190
ASP C  38
 None
 1.11A 5wwsB-5hj2C:
undetectable		 5wwsB-5hj2C:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 5hj2 INTEGRIN ALPHA-2
(Homo
sapiens) 		5 / 12 ALA C  90
VAL C 115
ILE C 167
VAL C  11
VAL C  13
 None
 0.91A 6dh0A-5hj2C:
undetectable		 6dh0A-5hj2C:
18.46