SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hj5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		5 / 12 ILE A  20
ALA A  17
ALA A  16
LEU A  52
ALA A  51
 None
 1.06A 1fbyA-5hj5A:
undetectable		 1fbyA-5hj5A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		5 / 12 VAL A 138
GLY A 137
GLY A 142
PHE A 146
LEU A 194
 None
F6R  A 301 (-3.2A)
None
F6R  A 301 ( 4.7A)
None
 1.08A 1fduA-5hj5A:
undetectable		 1fduA-5hj5A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		5 / 12 ILE A  20
ALA A  17
ALA A  16
LEU A  52
ALA A  51
 None
 1.00A 1fm6A-5hj5A:
undetectable		 1fm6A-5hj5A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		5 / 12 ILE A  20
ALA A  17
ALA A  16
LEU A  52
ALA A  51
 None
 0.97A 1k74A-5hj5A:
undetectable		 1k74A-5hj5A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		4 / 6 ASN A 147
ARG A 158
ILE A 188
GLY A 189
 None
 1.00A 1oniA-5hj5A:
undetectable
1oniB-5hj5A:
undetectable		 1oniA-5hj5A:
22.92
1oniB-5hj5A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		4 / 6 ASN A 147
ARG A 158
ILE A 188
GLY A 189
 None
 0.94A 1oniD-5hj5A:
undetectable
1oniF-5hj5A:
undetectable		 1oniD-5hj5A:
22.92
1oniF-5hj5A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		4 / 7 ILE A 188
GLY A 189
ASN A 147
ARG A 158
 None
 0.98A 1oniG-5hj5A:
undetectable
1oniI-5hj5A:
undetectable		 1oniG-5hj5A:
22.92
1oniI-5hj5A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		5 / 12 ILE A  20
ALA A  17
ALA A  16
LEU A  52
ALA A  51
 None
 0.99A 1xiuA-5hj5A:
undetectable		 1xiuA-5hj5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		5 / 12 ILE A  24
ILE A  97
THR A  48
LEU A  39
ILE A  20
 None
 1.06A 2cd2A-5hj5A:
undetectable		 2cd2A-5hj5A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		4 / 5 LEU A 153
VAL A 238
LEU A 202
ARG A  23
 None
 1.08A 2oiqA-5hj5A:
undetectable		 2oiqA-5hj5A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		4 / 7 ILE A  20
PHE A  63
ILE A  99
PHE A  93
 None
 1.17A 2qb4A-5hj5A:
undetectable		 2qb4A-5hj5A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		5 / 10 ASP A 195
ILE A 188
GLY A 189
LEU A 153
ILE A 199
 None
 1.05A 3em4V-5hj5A:
undetectable		 3em4V-5hj5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		5 / 10 ILE A  20
ALA A  17
ALA A  16
LEU A  52
ALA A  51
 None
 1.01A 3falC-5hj5A:
undetectable		 3falC-5hj5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		5 / 12 ILE A 237
VAL A 203
GLU A 241
VAL A 216
ARG A   2
 None
 1.14A 3fpjB-5hj5A:
2.3		 3fpjB-5hj5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		5 / 9 LEU A  37
ALA A 196
ASP A 195
ILE A 201
LEU A  39
 None
 1.10A 3u7sA-5hj5A:
undetectable		 3u7sA-5hj5A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		4 / 7 ALA A 185
ILE A 159
HIS A 114
GLY A 109
 None
 0.99A 3v4tH-5hj5A:
undetectable		 3v4tH-5hj5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		3 / 3 LYS A 124
TYR A 121
ARG A 120
 None
None
GOL  A 304 ( 4.5A)
 0.92A 4gc9A-5hj5A:
2.7		 4gc9A-5hj5A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		5 / 9 THR A  44
ALA A 169
VAL A 203
GLY A 137
ASP A 141
 F6R  A 301 (-3.5A)
None
None
F6R  A 301 (-3.2A)
None
 0.98A 4qvnK-5hj5A:
undetectable
4qvnL-5hj5A:
undetectable		 4qvnK-5hj5A:
22.78
4qvnL-5hj5A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		5 / 9 THR A  44
ALA A 169
VAL A 203
GLY A 137
ASP A 141
 F6R  A 301 (-3.5A)
None
None
F6R  A 301 (-3.2A)
None
 0.98A 4qvnY-5hj5A:
undetectable
4qvnZ-5hj5A:
undetectable		 4qvnY-5hj5A:
22.78
4qvnZ-5hj5A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		5 / 10 TRP A  15
LEU A 133
LEU A 229
ALA A 235
GLY A 136
 None
 1.45A 4rn6A-5hj5A:
undetectable		 4rn6A-5hj5A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		5 / 11 ALA A 215
ALA A 211
VAL A 138
LEU A 212
LEU A   3
 None
 1.15A 5eb5A-5hj5A:
undetectable		 5eb5A-5hj5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		5 / 12 ILE A  20
ALA A  17
ALA A  16
LEU A  52
ALA A  51
 None
 0.93A 5uanA-5hj5A:
undetectable		 5uanA-5hj5A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		5 / 10 ILE A 199
ILE A 201
LEU A 202
ILE A 131
ASN A 132
 None
 1.43A 5vkqA-5hj5A:
undetectable
5vkqD-5hj5A:
undetectable		 5vkqA-5hj5A:
9.29
5vkqD-5hj5A:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		5 / 10 ILE A 131
ASN A 132
ILE A 199
ILE A 201
LEU A 202
 None
 1.42A 5vkqC-5hj5A:
undetectable
5vkqD-5hj5A:
undetectable		 5vkqC-5hj5A:
9.29
5vkqD-5hj5A:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		5 / 12 ILE A  20
ALA A  17
ALA A  16
LEU A  52
ALA A  51
 None
 0.99A 5z12C-5hj5A:
undetectable		 5z12C-5hj5A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Vibrio
cholerae) 		5 / 12 PHE A  63
ILE A  24
PHE A  93
THR A  48
PHE A 134
 None
 1.18A 6e8qA-5hj5A:
undetectable		 6e8qA-5hj5A:
13.86