SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hjl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Streptococcus
porcinus) 		5 / 12 LEU A 157
LEU A 115
ALA A 120
LEU A  86
ILE A 245
 None
 1.12A 1crbA-5hjlA:
undetectable		 1crbA-5hjlA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Streptococcus
porcinus) 		5 / 9 TYR A 144
ILE A 145
TYR A  90
ILE A 148
GLU A 151
 None
 1.35A 1mrgA-5hjlA:
undetectable		 1mrgA-5hjlA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Streptococcus
porcinus) 		4 / 5 PRO A 208
VAL A 186
ASN A 187
VAL A 205
 None
 1.06A 1z2bC-5hjlA:
undetectable		 1z2bC-5hjlA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Streptococcus
porcinus) 		4 / 7 TYR A 213
GLU A 219
LEU A 223
LYS A 180
 None
 1.34A 3k8mA-5hjlA:
7.2		 3k8mA-5hjlA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Streptococcus
porcinus) 		4 / 6 MET A 190
ILE A 163
GLU A 188
ASN A 187
 None
 1.47A 3kp6A-5hjlA:
undetectable
3kp6B-5hjlA:
0.3		 3kp6A-5hjlA:
20.43
3kp6B-5hjlA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Streptococcus
porcinus) 		4 / 5 LEU A  67
ILE A  20
ALA A 122
PHE A 160
 None
 0.86A 4dc3B-5hjlA:
undetectable		 4dc3B-5hjlA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Streptococcus
porcinus) 		5 / 12 LEU A  51
PHE A  25
PRO A  43
ASP A  26
GLY A  29
 None
None
None
None
SO4  A 403 (-3.8A)
 1.36A 4j7xF-5hjlA:
undetectable		 4j7xF-5hjlA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Streptococcus
porcinus) 		5 / 12 LEU A 203
LEU A 161
ILE A 163
ASN A 138
SER A 194
 None
 0.99A 4lmnA-5hjlA:
undetectable		 4lmnA-5hjlA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Streptococcus
porcinus) 		4 / 7 TYR A  10
ASP A 156
SER A   5
ALA A   9
 None
 1.22A 4lv9A-5hjlA:
4.8
4lv9B-5hjlA:
3.7		 4lv9A-5hjlA:
22.40
4lv9B-5hjlA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Streptococcus
porcinus) 		5 / 12 ALA A 253
GLN A 254
LEU A 255
ASP A 312
ALA A 318
 None
 1.10A 4pclA-5hjlA:
undetectable		 4pclA-5hjlA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Streptococcus
porcinus) 		5 / 12 VAL A 131
LEU A 164
LEU A 203
LEU A 242
ALA A 195
 None
 1.28A 4rtbA-5hjlA:
3.9		 4rtbA-5hjlA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Streptococcus
porcinus) 		3 / 3 ASP A 172
ARG A 277
ARG A  33
 None
SO4  A 401 (-3.6A)
SO4  A 403 (-2.5A)
 0.86A 4x5iA-5hjlA:
undetectable		 4x5iA-5hjlA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Streptococcus
porcinus) 		5 / 9 TYR A 144
ILE A 145
TYR A  90
ILE A 148
GLU A 151
 None
 1.08A 4yp2B-5hjlA:
undetectable		 4yp2B-5hjlA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Streptococcus
porcinus) 		5 / 9 TYR A 144
ILE A 145
TYR A  90
ILE A 148
GLU A 151
 None
 1.08A 5cf9B-5hjlA:
undetectable		 5cf9B-5hjlA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Streptococcus
porcinus) 		4 / 5 SER A 240
ALA A 239
HIS A 241
LEU A 203
 None
 1.44A 5dzkc-5hjlA:
1.6
5dzkq-5hjlA:
undetectable		 5dzkc-5hjlA:
22.80
5dzkq-5hjlA:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Streptococcus
porcinus) 		4 / 5 SER A 240
ALA A 239
HIS A 241
LEU A 203
 None
 1.40A 5dzkf-5hjlA:
1.9
5dzkt-5hjlA:
undetectable		 5dzkf-5hjlA:
22.80
5dzkt-5hjlA:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Streptococcus
porcinus) 		3 / 3 ASP A 172
ARG A 277
ARG A  33
 None
SO4  A 401 (-3.6A)
SO4  A 403 (-2.5A)
 0.75A 5eajB-5hjlA:
undetectable		 5eajB-5hjlA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Streptococcus
porcinus) 		4 / 8 GLN A 236
LEU A 247
MET A 211
THR A 259
 None
SO4  A 401 ( 4.5A)
None
None
 1.18A 5hs6A-5hjlA:
2.3		 5hs6A-5hjlA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Streptococcus
porcinus) 		4 / 7 PRO A 104
TYR A 144
ILE A 148
ILE A 145
 None
 0.84A 5murB-5hjlA:
undetectable		 5murB-5hjlA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Streptococcus
porcinus) 		5 / 12 LEU A 255
VAL A 251
PHE A 262
PHE A 233
ALA A 232
 None
 0.74A 5uxdB-5hjlA:
undetectable		 5uxdB-5hjlA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Streptococcus
porcinus) 		4 / 6 TYR A 144
TYR A  90
ILE A 148
GLU A 151
 None
 1.00A 5z3jA-5hjlA:
undetectable		 5z3jA-5hjlA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE
(Streptococcus
porcinus) 		5 / 11 ALA A  22
LEU A  23
THR A  60
ILE A  77
ALA A  76
 None
 1.22A 6h1lB-5hjlA:
undetectable		 6h1lB-5hjlA:
22.53