SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hjn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5hjn LD10117P
(Drosophila
melanogaster) 		5 / 12 TYR A 112
VAL A 116
ILE A 130
LEU A 132
VAL A 136
 None
 0.69A 1oipA-5hjnA:
3.3		 1oipA-5hjnA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5hjn LD10117P
(Drosophila
melanogaster) 		4 / 6 ARG A 281
ILE A 334
ALA A 283
HIS A 227
 SO4  A 401 (-3.4A)
None
None
None
 0.99A 1wmqA-5hjnA:
undetectable		 1wmqA-5hjnA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5hjn LD10117P
(Drosophila
melanogaster) 		4 / 6 ARG A 281
ILE A 334
ALA A 283
HIS A 227
 SO4  A 401 (-3.4A)
None
None
None
 1.00A 1wmqB-5hjnA:
undetectable		 1wmqB-5hjnA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5hjn LD10117P
(Drosophila
melanogaster) 		4 / 6 ARG A 281
ILE A 334
ALA A 283
HIS A 227
 SO4  A 401 (-3.4A)
None
None
None
 0.99A 1wpuA-5hjnA:
undetectable		 1wpuA-5hjnA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5hjn LD10117P
(Drosophila
melanogaster) 		4 / 6 ARG A 281
ILE A 334
ALA A 283
HIS A 227
 SO4  A 401 (-3.4A)
None
None
None
 1.00A 1wpuB-5hjnA:
undetectable		 1wpuB-5hjnA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5hjn LD10117P
(Drosophila
melanogaster) 		4 / 6 ARG A 281
ILE A 334
ALA A 283
HIS A 227
 SO4  A 401 (-3.4A)
None
None
None
 1.00A 1wrqA-5hjnA:
undetectable		 1wrqA-5hjnA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5hjn LD10117P
(Drosophila
melanogaster) 		4 / 6 ARG A 281
ILE A 334
ALA A 283
HIS A 227
 SO4  A 401 (-3.4A)
None
None
None
 1.00A 1wrqB-5hjnA:
undetectable		 1wrqB-5hjnA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5hjn LD10117P
(Drosophila
melanogaster) 		5 / 12 TYR A 112
VAL A 116
ILE A 130
LEU A 132
VAL A 136
 None
 0.95A 3w67C-5hjnA:
undetectable		 3w67C-5hjnA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5hjn LD10117P
(Drosophila
melanogaster) 		5 / 12 TYR A 112
VAL A 116
ILE A 130
LEU A 132
VAL A 136
 None
 0.71A 3w68A-5hjnA:
2.4		 3w68A-5hjnA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5hjn LD10117P
(Drosophila
melanogaster) 		5 / 12 TYR A 112
VAL A 116
ILE A 130
LEU A 132
VAL A 136
 None
 0.99A 3w68B-5hjnA:
undetectable		 3w68B-5hjnA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5hjn LD10117P
(Drosophila
melanogaster) 		5 / 12 TYR A 112
VAL A 116
ILE A 130
LEU A 132
VAL A 136
 None
 0.78A 3w68D-5hjnA:
2.5		 3w68D-5hjnA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5hjn LD10117P
(Drosophila
melanogaster) 		4 / 4 ILE A  62
ILE A  77
ARG A  57
LEU A  66
 None
 1.23A 5dzkh-5hjnA:
undetectable
5dzkn-5hjnA:
undetectable
5dzkv-5hjnA:
undetectable		 5dzkh-5hjnA:
20.16
5dzkn-5hjnA:
20.16
5dzkv-5hjnA:
0.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 5hjn LD10117P
(Drosophila
melanogaster) 		4 / 6 ILE A 320
GLY A 310
ASN A 311
ILE A 286
 None
 0.91A 5j4nB-5hjnA:
undetectable		 5j4nB-5hjnA:
21.06