SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hjp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ND4_A_KANA1300_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		 5hjp OXYSTEROLS RECEPTOR
LXR-BETA
(Homo
sapiens) 		5 / 10 ASP B 245
ARG B 473
ARG B 241
ASP B 284
GLU B 281
 None
None
None
None
668  B 501 (-3.4A)
 1.46A 1nd4A-5hjpB:
undetectable		 1nd4A-5hjpB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5hjp OXYSTEROLS RECEPTOR
LXR-BETA
(Homo
sapiens) 		4 / 7 LEU B 345
PHE B 340
ARG B 319
LEU B 313
 668  B 501 (-3.5A)
None
668  B 501 (-3.6A)
None
 1.11A 2eikA-5hjpB:
undetectable
2eikJ-5hjpB:
undetectable		 2eikA-5hjpB:
18.22
2eikJ-5hjpB:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5hjp OXYSTEROLS RECEPTOR
LXR-BETA
(Homo
sapiens) 		6 / 12 GLU B 455
GLY B 464
GLY B 466
SER B 454
LEU B 449
THR B 272
 None
None
None
None
668  B 501 (-4.9A)
668  B 501 (-4.5A)
 1.42A 4uckA-5hjpB:
undetectable		 4uckA-5hjpB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5hjp OXYSTEROLS RECEPTOR
LXR-BETA
(Homo
sapiens) 		5 / 9 ALA B 286
GLN B 288
GLU B 315
LEU B 304
ILE B 378
 None
 1.42A 5i73A-5hjpB:
undetectable		 5i73A-5hjpB:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5hjp OXYSTEROLS RECEPTOR
LXR-BETA
(Homo
sapiens) 		4 / 6 LEU B 475
ASP B 477
ARG B 297
GLN B 288
 None
 1.24A 6g31J-5hjpB:
undetectable		 6g31J-5hjpB:
13.26