SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hk8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 5hk8 PROBABLE
PHEOPHORBIDASE
(Arabidopsis
thaliana) 		3 / 3 TRP A  24
VAL A  43
TRP A  26
 None
 1.34A 1gmkC-5hk8A:
undetectable
1gmkD-5hk8A:
undetectable		 1gmkC-5hk8A:
4.23
1gmkD-5hk8A:
4.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5hk8 PROBABLE
PHEOPHORBIDASE
(Arabidopsis
thaliana) 		5 / 9 GLY A  18
ALA A  19
SER A  87
TRP A 136
HIS A 239
 None
 0.99A 1y7iA-5hk8A:
33.8		 1y7iA-5hk8A:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 5hk8 PROBABLE
PHEOPHORBIDASE
(Arabidopsis
thaliana) 		5 / 11 ILE A 206
ALA A 112
PHE A  15
ILE A  82
VAL A 204
 None
 1.15A 2w3aA-5hk8A:
undetectable		 2w3aA-5hk8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5hk8 PROBABLE
PHEOPHORBIDASE
(Arabidopsis
thaliana) 		4 / 6 ILE A 108
ARG A 255
THR A 248
LEU A 249
 None
 1.00A 3ag1N-5hk8A:
undetectable
3ag1W-5hk8A:
undetectable		 3ag1N-5hk8A:
20.08
3ag1W-5hk8A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 5hk8 PROBABLE
PHEOPHORBIDASE
(Arabidopsis
thaliana) 		4 / 7 LEU A 213
TYR A 163
HIS A  86
HIS A  21
 None
 1.38A 4arcA-5hk8A:
undetectable		 4arcA-5hk8A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 5hk8 PROBABLE
PHEOPHORBIDASE
(Arabidopsis
thaliana) 		3 / 3 ASP A 211
TRP A 136
SER A  87
 None
 1.02A 4lrhB-5hk8A:
undetectable		 4lrhB-5hk8A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 5hk8 PROBABLE
PHEOPHORBIDASE
(Arabidopsis
thaliana) 		3 / 3 ASP A 211
TRP A 136
SER A  87
 None
 1.10A 4lrhF-5hk8A:
undetectable		 4lrhF-5hk8A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M7T_A_SAMA503_0
(BTRN)		 5hk8 PROBABLE
PHEOPHORBIDASE
(Arabidopsis
thaliana) 		5 / 11 THR A  41
HIS A  12
LEU A  71
LEU A  72
SER A  73
 None
 1.35A 4m7tA-5hk8A:
1.9		 4m7tA-5hk8A:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5hk8 PROBABLE
PHEOPHORBIDASE
(Arabidopsis
thaliana) 		5 / 12 TYR A 205
GLY A  85
GLY A  90
ILE A 108
LEU A 249
 None
 1.11A 4mwzA-5hk8A:
undetectable		 4mwzA-5hk8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 5hk8 PROBABLE
PHEOPHORBIDASE
(Arabidopsis
thaliana) 		5 / 10 TYR A  64
LEU A 189
ALA A 107
ALA A  96
GLY A  90
 None
 1.20A 4rn6A-5hk8A:
undetectable		 4rn6A-5hk8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 5hk8 PROBABLE
PHEOPHORBIDASE
(Arabidopsis
thaliana) 		5 / 10 TYR A  64
LEU A 189
LEU A  83
ALA A  96
GLY A  90
 None
 1.11A 4rn6A-5hk8A:
undetectable		 4rn6A-5hk8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 5hk8 PROBABLE
PHEOPHORBIDASE
(Arabidopsis
thaliana) 		5 / 12 TYR A  64
LEU A 189
LEU A  83
ALA A  96
GLY A  90
 None
 1.02A 4rn6B-5hk8A:
undetectable		 4rn6B-5hk8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5hk8 PROBABLE
PHEOPHORBIDASE
(Arabidopsis
thaliana) 		5 / 12 GLY A  18
GLY A  89
GLY A  90
HIS A  21
LEU A 213
 None
 0.90A 5c0oF-5hk8A:
undetectable		 5c0oF-5hk8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5hk8 PROBABLE
PHEOPHORBIDASE
(Arabidopsis
thaliana) 		5 / 12 GLY A  89
ASP A 211
HIS A 239
ILE A 206
TYR A 205
 None
 1.19A 5igvA-5hk8A:
undetectable		 5igvA-5hk8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5hk8 PROBABLE
PHEOPHORBIDASE
(Arabidopsis
thaliana) 		5 / 12 GLY A  90
ASP A 211
HIS A 239
ILE A 206
TYR A 205
 None
 1.13A 5igvA-5hk8A:
undetectable		 5igvA-5hk8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 5hk8 PROBABLE
PHEOPHORBIDASE
(Arabidopsis
thaliana) 		4 / 7 SER A 166
PRO A 246
PHE A 242
SER A 174
 None
 0.75A 5l1fC-5hk8A:
3.5		 5l1fC-5hk8A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5hk8 PROBABLE
PHEOPHORBIDASE
(Arabidopsis
thaliana) 		4 / 6 ILE A 108
ARG A 255
THR A 248
LEU A 249
 None
 1.03A 5zcoN-5hk8A:
undetectable
5zcoW-5hk8A:
undetectable		 5zcoN-5hk8A:
20.08
5zcoW-5hk8A:
10.40