SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hke'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
4 / 8 TYR A  64
PHE A 100
GLU A  27
GLY A  55
None
1.06A 1ykiA-5hkeA:
undetectable
1ykiB-5hkeA:
undetectable
1ykiA-5hkeA:
19.76
1ykiB-5hkeA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
4 / 8 TYR A  64
PHE A 100
GLU A  27
GLY A  55
None
1.08A 1ykiA-5hkeA:
undetectable
1ykiB-5hkeA:
undetectable
1ykiA-5hkeA:
19.76
1ykiB-5hkeA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
4 / 8 TYR A  64
PHE A 100
GLU A  27
GLY A  55
None
1.08A 1ykiC-5hkeA:
undetectable
1ykiD-5hkeA:
undetectable
1ykiC-5hkeA:
19.76
1ykiD-5hkeA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
4 / 8 TYR A  64
PHE A 100
GLU A  27
GLY A  55
None
1.04A 1ykiC-5hkeA:
undetectable
1ykiD-5hkeA:
undetectable
1ykiC-5hkeA:
19.76
1ykiD-5hkeA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
4 / 5 ILE A 106
LEU A 107
ASP A 145
ALA A 116
None
1.06A 2opxA-5hkeA:
undetectable
2opxA-5hkeA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
4 / 7 ILE A 103
LEU A 125
LEU A 139
GLY A  77
None
0.98A 2qqcD-5hkeA:
undetectable
2qqcE-5hkeA:
undetectable
2qqcD-5hkeA:
16.72
2qqcE-5hkeA:
9.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
3 / 3 ASN A  79
ASN A 171
ARG A 224
OCS  A   2 ( 3.7A)
OCS  A   2 ( 3.2A)
OCS  A   2 ( 3.3A)
0.77A 2rlcA-5hkeA:
42.3
2rlcA-5hkeA:
36.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
5 / 12 PHE A  80
PHE A  65
LEU A  63
PHE A 102
GLY A  77
None
1.31A 2zznB-5hkeA:
undetectable
2zznB-5hkeA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
3 / 3 TYR A  35
TYR A  64
ILE A  29
None
0.77A 3eteA-5hkeA:
undetectable
3eteB-5hkeA:
undetectable
3eteA-5hkeA:
21.48
3eteB-5hkeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
3 / 3 TYR A  64
TYR A 278
ILE A  68
None
0.68A 3eteA-5hkeA:
undetectable
3eteB-5hkeA:
undetectable
3eteA-5hkeA:
21.48
3eteB-5hkeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
4 / 6 LEU A 134
SER A 129
PHE A 130
PHE A 102
None
0.95A 3ko0B-5hkeA:
undetectable
3ko0B-5hkeA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
4 / 5 ASN A  79
LEU A 139
LEU A 136
ASN A 127
OCS  A   2 ( 3.7A)
None
None
None
1.26A 4n09C-5hkeA:
undetectable
4n09C-5hkeA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
4 / 5 ASP A  21
LEU A  20
ARG A  16
THR A 264
None
None
OCS  A   2 ( 4.1A)
None
1.39A 4p3qA-5hkeA:
undetectable
4p3qA-5hkeA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
4 / 6 THR A  31
ASP A  60
TYR A  64
LEU A  63
None
0.84A 4wozA-5hkeA:
undetectable
4wozB-5hkeA:
undetectable
4wozA-5hkeA:
24.51
4wozB-5hkeA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
4 / 5 ASP A  60
TYR A  64
LEU A  63
THR A  31
None
0.87A 4wozF-5hkeA:
undetectable
4wozH-5hkeA:
undetectable
4wozF-5hkeA:
24.51
4wozH-5hkeA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
3 / 3 SER A 231
ALA A 228
THR A   3
None
None
OCS  A   2 ( 3.8A)
0.73A 5n0xB-5hkeA:
undetectable
5n0xB-5hkeA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
4 / 6 ARG A  40
PHE A 100
ILE A  97
THR A  98
None
1.04A 5vceA-5hkeA:
undetectable
5vceA-5hkeA:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
7 / 10 LEU A  18
LEU A  63
ASN A  79
PHE A 100
LEU A 136
ALA A 137
LEU A 139
OCS  A   2 ( 3.9A)
None
OCS  A   2 ( 3.7A)
None
None
None
None
1.39A 5y7pB-5hkeA:
52.3
5y7pB-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
8 / 10 LEU A  18
TYR A  24
ILE A  56
LEU A  63
PHE A 100
LEU A 136
ALA A 137
LEU A 139
OCS  A   2 ( 3.9A)
None
None
None
None
None
None
None
1.43A 5y7pB-5hkeA:
52.3
5y7pB-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
9 / 10 LEU A  20
TYR A  24
ILE A  56
LEU A  63
PHE A  65
PHE A 100
LEU A 136
ALA A 137
LEU A 139
None
0.61A 5y7pB-5hkeA:
52.3
5y7pB-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
6 / 8 LEU A  18
ILE A  56
PHE A 100
LEU A 136
ALA A 137
LEU A 139
OCS  A   2 ( 3.9A)
None
None
None
None
None
1.26A 5y7pC-5hkeA:
52.3
5y7pC-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
7 / 8 LEU A  20
ILE A  56
ASN A  79
PHE A 100
LEU A 136
ALA A 137
LEU A 139
None
None
OCS  A   2 ( 3.7A)
None
None
None
None
0.38A 5y7pC-5hkeA:
52.3
5y7pC-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
4 / 8 LEU A  20
TYR A  24
ASN A  79
ALA A 137
None
None
OCS  A   2 ( 3.7A)
None
0.82A 5y7pC-5hkeA:
52.3
5y7pC-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
6 / 10 LEU A  18
ASN A  79
PHE A 100
LEU A 136
ALA A 137
LEU A 139
OCS  A   2 ( 3.9A)
OCS  A   2 ( 3.7A)
None
None
None
None
1.23A 5y7pD-5hkeA:
52.5
5y7pD-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
8 / 10 LEU A  18
TYR A  24
ILE A  56
LEU A  63
PHE A 100
LEU A 136
ALA A 137
LEU A 139
OCS  A   2 ( 3.9A)
None
None
None
None
None
None
None
1.46A 5y7pD-5hkeA:
52.5
5y7pD-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
9 / 10 LEU A  20
TYR A  24
ILE A  56
LEU A  63
PHE A  65
PHE A 100
LEU A 136
ALA A 137
LEU A 139
None
0.57A 5y7pD-5hkeA:
52.5
5y7pD-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
7 / 8 ILE A  56
ASN A  79
PHE A 100
LEU A 134
LEU A 136
ALA A 137
LEU A 139
None
OCS  A   2 ( 3.7A)
None
None
None
None
None
0.37A 5y7pE-5hkeA:
52.4
5y7pE-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
7 / 10 ASN A  79
PHE A 100
LEU A 134
LEU A 136
ALA A 137
LEU A 139
GLU A 270
OCS  A   2 ( 3.7A)
None
None
None
None
None
None
0.76A 5y7pG-5hkeA:
52.5
5y7pG-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
7 / 10 LEU A  18
ASN A  79
PHE A 100
LEU A 134
LEU A 136
ALA A 137
LEU A 139
OCS  A   2 ( 3.9A)
OCS  A   2 ( 3.7A)
None
None
None
None
None
1.35A 5y7pG-5hkeA:
52.5
5y7pG-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
8 / 10 LEU A  18
TYR A  24
ILE A  56
PHE A 100
LEU A 134
LEU A 136
ALA A 137
LEU A 139
OCS  A   2 ( 3.9A)
None
None
None
None
None
None
None
1.37A 5y7pG-5hkeA:
52.5
5y7pG-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
9 / 10 LEU A  20
TYR A  24
ILE A  56
PHE A 100
LEU A 134
LEU A 136
ALA A 137
LEU A 139
GLU A 270
None
0.51A 5y7pG-5hkeA:
52.5
5y7pG-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
7 / 10 LEU A  18
LEU A  63
ASN A  79
PHE A 100
LEU A 136
ALA A 137
LEU A 139
OCS  A   2 ( 3.9A)
None
OCS  A   2 ( 3.7A)
None
None
None
None
1.37A 5y7pH-5hkeA:
52.2
5y7pH-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
8 / 10 LEU A  18
TYR A  24
ILE A  56
LEU A  63
PHE A 100
LEU A 136
ALA A 137
LEU A 139
OCS  A   2 ( 3.9A)
None
None
None
None
None
None
None
1.44A 5y7pH-5hkeA:
52.2
5y7pH-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
9 / 10 LEU A  20
TYR A  24
ILE A  56
LEU A  63
PHE A  65
PHE A 100
LEU A 136
ALA A 137
LEU A 139
None
0.60A 5y7pH-5hkeA:
52.2
5y7pH-5hkeA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNC_A_QI9A301_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
5hke BILE SALT HYDROLASE
(Lactobacillus
salivarius)
5 / 9 GLY A  53
TYR A 274
VAL A  28
GLU A  27
ASP A  66
None
1.12A 5zncA-5hkeA:
undetectable
5zncA-5hkeA:
19.01