SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hkf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QD5_B_CHDB1103_0 (FERROCHELATASE)	5hkf	OROTATE PHOSPHORIBOSYLTRANSF ERASE (Mycobacterium tuberculosis)	4 / 8	ARG A 38 SER A 109 VAL A 119 GLY A 68	PRP A 201 (-2.4A) None None None	1.11A	2qd5B-5hkfA: undetectable	2qd5B-5hkfA: 20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BOY_A_HISA1001_0 (HUT OPERON POSITIVE REGULATORY PROTEIN)	5hkf	OROTATE PHOSPHORIBOSYLTRANSF ERASE (Mycobacterium tuberculosis)	5 / 10	ARG A 55 ILE A 80 GLY A 51 ALA A 48 HIS A 82	None	1.29A	3boyA-5hkfA: undetectable 3boyC-5hkfA: undetectable	3boyA-5hkfA: 23.62 3boyC-5hkfA: 23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BOY_A_HISA2001_0 (HUT OPERON POSITIVE REGULATORY PROTEIN)	5hkf	OROTATE PHOSPHORIBOSYLTRANSF ERASE (Mycobacterium tuberculosis)	5 / 10	HIS A 82 ARG A 55 ILE A 80 GLY A 51 ALA A 48	None	1.29A	3boyA-5hkfA: undetectable 3boyB-5hkfA: undetectable	3boyA-5hkfA: 23.62 3boyB-5hkfA: 23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BOY_A_HISA3001_0 (HUT OPERON POSITIVE REGULATORY PROTEIN)	5hkf	OROTATE PHOSPHORIBOSYLTRANSF ERASE (Mycobacterium tuberculosis)	5 / 10	HIS A 82 ARG A 55 ILE A 80 GLY A 51 ALA A 48	None	1.29A	3boyB-5hkfA: undetectable 3boyC-5hkfA: undetectable	3boyB-5hkfA: 23.62 3boyC-5hkfA: 23.62

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2QD5_B_CHDB1103_0","FERROCHELATASE","5hkf","OROTATE PHOSPHORIBOSYLTRANSFERASE","Mycobacterium tuberculosis",4,"ARG A  38;SER A 109;VAL A 119;GLY A  68","PRP A 201 (-2.4A);None;None;None","1.11A","2qd5B-5hkfA:undetectable","2qd5B-5hkfA:20.48"],["3BOY_A_HISA1001_0","HUT OPERON POSITIVE REGULATORY PROTEIN","5hkf","OROTATE PHOSPHORIBOSYLTRANSFERASE","Mycobacterium tuberculosis",5,"ARG A  55;ILE A  80;GLY A  51;ALA A  48;HIS A  82","None","1.29A","3boyA-5hkfA:undetectable;3boyC-5hkfA:undetectable","3boyA-5hkfA:23.62;3boyC-5hkfA:23.62"],["3BOY_A_HISA2001_0","HUT OPERON POSITIVE REGULATORY PROTEIN","5hkf","OROTATE PHOSPHORIBOSYLTRANSFERASE","Mycobacterium tuberculosis",5,"HIS A  82;ARG A  55;ILE A  80;GLY A  51;ALA A  48","None","1.29A","3boyA-5hkfA:undetectable;3boyB-5hkfA:undetectable","3boyA-5hkfA:23.62;3boyB-5hkfA:23.62"],["3BOY_A_HISA3001_0","HUT OPERON POSITIVE REGULATORY PROTEIN","5hkf","OROTATE PHOSPHORIBOSYLTRANSFERASE","Mycobacterium tuberculosis",5,"HIS A  82;ARG A  55;ILE A  80;GLY A  51;ALA A  48","None","1.29A","3boyB-5hkfA:undetectable;3boyC-5hkfA:undetectable","3boyB-5hkfA:23.62;3boyC-5hkfA:23.62"]]