SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5hkq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 5hkq CDII IMMUNITY
PROTEIN
CONTACT-DEPENDENT
INHIBITOR A
(Escherichia
coli) 		4 / 8 TYR A 236
HIS A 204
PHE A 209
ASP I  48
 None
 1.05A 1e7cA-5hkqA:
undetectable		 1e7cA-5hkqA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 5hkq CDII IMMUNITY
PROTEIN
CONTACT-DEPENDENT
INHIBITOR A
(Escherichia
coli) 		4 / 8 ASN I   2
LEU A 294
TYR I  10
LEU I  25
 None
 1.13A 1hk3A-5hkqI:
undetectable		 1hk3A-5hkqI:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5hkq CDII IMMUNITY
PROTEIN
(Escherichia
coli) 		3 / 3 LYS I   3
ASP I  34
ASN I  30
 None
 1.09A 2bm9A-5hkqI:
undetectable		 2bm9A-5hkqI:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 5hkq CDII IMMUNITY
PROTEIN
CONTACT-DEPENDENT
INHIBITOR A
(Escherichia
coli) 		4 / 6 ASN I   2
ASN I  28
ILE I  50
THR A 305
 None
 1.14A 2hkkA-5hkqI:
undetectable		 2hkkA-5hkqI:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5hkq CDII IMMUNITY
PROTEIN
(Escherichia
coli) 		4 / 5 PRO I  76
ILE I  46
GLY I  49
TYR I  75
 None
 1.10A 2jkjD-5hkqI:
undetectable		 2jkjD-5hkqI:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5hkq CDII IMMUNITY
PROTEIN
(Escherichia
coli) 		4 / 5 PRO I  76
ILE I  46
GLY I  49
TYR I  75
 None
 1.10A 2jkjF-5hkqI:
undetectable		 2jkjF-5hkqI:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 5hkq CONTACT-DEPENDENT
INHIBITOR A
CDII IMMUNITY
PROTEIN
(Escherichia
coli;
Escherichia
coli) 		3 / 3 ALA I  72
VAL I  73
GLN A 295
 None
 0.43A 3of4B-5hkqI:
undetectable		 3of4B-5hkqI:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 5hkq CDII IMMUNITY
PROTEIN
CONTACT-DEPENDENT
INHIBITOR A
(Escherichia
coli) 		4 / 7 ASP I  48
PHE A 209
VAL A 218
ILE A 220
 None
 0.99A 3pglA-5hkqI:
undetectable		 3pglA-5hkqI:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5hkq CDII IMMUNITY
PROTEIN
(Escherichia
coli) 		4 / 8 VAL I  73
VAL I  83
TYR I  22
TYR I  10
 None
 0.92A 3v81C-5hkqI:
undetectable		 3v81C-5hkqI:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5hkq CONTACT-DEPENDENT
INHIBITOR A
(Escherichia
coli) 		5 / 12 VAL A 234
ILE A 220
ILE A 268
HIS A 204
VAL A 213
 None
 1.05A 4a97B-5hkqA:
undetectable
4a97C-5hkqA:
undetectable		 4a97B-5hkqA:
17.11
4a97C-5hkqA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 5hkq CDII IMMUNITY
PROTEIN
CONTACT-DEPENDENT
INHIBITOR A
(Escherichia
coli) 		4 / 7 HIS A 321
ASP I  48
HIS A 204
GLU A 260
 None
 1.10A 4hvrA-5hkqA:
undetectable		 4hvrA-5hkqA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5hkq CDII IMMUNITY
PROTEIN
(Escherichia
coli) 		5 / 12 LEU I 115
ALA I  35
PHE I  23
PHE I   6
ARG I  20
 None
 1.13A 4hytA-5hkqI:
undetectable		 4hytA-5hkqI:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5hkq CDII IMMUNITY
PROTEIN
(Escherichia
coli) 		5 / 12 LEU I 115
ALA I  35
PHE I  23
PHE I   6
ARG I  20
 None
 1.14A 4hytC-5hkqI:
undetectable		 4hytC-5hkqI:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 5hkq CDII IMMUNITY
PROTEIN
(Escherichia
coli) 		3 / 3 VAL I  85
SER I  86
THR I  89
 None
 0.48A 4luhA-5hkqI:
undetectable		 4luhA-5hkqI:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5hkq CDII IMMUNITY
PROTEIN
(Escherichia
coli) 		4 / 8 VAL I  73
VAL I  83
TYR I  22
TYR I  10
 None
 0.94A 4pwdC-5hkqI:
undetectable		 4pwdC-5hkqI:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 5hkq CONTACT-DEPENDENT
INHIBITOR A
(Escherichia
coli) 		4 / 5 HIS A 321
VAL A 304
GLY A 278
ALA A 281
 None
 0.97A 5hwaA-5hkqA:
undetectable		 5hwaA-5hkqA:
20.85